Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > EIF2AK3(Gene name) > Human
  • Add your favorite
  • EIF2AK3 (Gene name),
  • Eukaryotic translation initiation factor 2-alpha kinase 3 (Protein name ),  E2AK3_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    EIF2AK3(PEK;PERK);
    Protein name:
    Eukaryotic translation initiation factor 2-alpha kinase 3;
    Alternative:
    Pancreatic eIF2-alpha kinase(HsPEK);PRKR-like endoplasmic reticulum kinase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.
    Function:
    Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1116
    Sequence:
    50:
    MERAISPGLL | VRALLLLLLL | LGLAARTVAA | GRARGLPAPT | AEAAFGLGAA | 
    100:
    AAPTSATRVP | AAGAVAAAEV | TVEDAEALPA | AAGEQEPRGP | EPDDETELRP | 
    150:
    RGRSLVIIST | LDGRIAALDP | ENHGKKQWDL | DVGSGSLVSS | SLSKPEVFGN | 
    200:
    KMIIPSLDGA | LFQWDQDRES | METVPFTVES | LLESSYKFGD | DVVLVGGKSL | 
    250:
    TTYGLSAYSG | KVRYICSALG | CRQWDSDEME | QEEDILLLQR | TQKTVRAVGP | 
    300:
    RSGNEKWNFS | VGHFELRYIP | DMETRAGFIE | STFKPNENTE | ESKIISDVEE | 
    350:
    QEAAIMDIVI | KVSVADWKVM | AFSKKGGHLE | WEYQFCTPIA | SAWLLKDGKV | 
    400:
    IPISLFDDTS | YTSNDDVLED | EEDIVEAARG | ATENSVYLGM | YRGQLYLQSS | 
    450:
    VRISEKFPSS | PKALESVTNE | NAIIPLPTIK | WKPLIHSPSR | TPVLVGSDEF | 
    500:
    DKCLSNDKFS | HEEYSNGALS | ILQYPYDNGY | YLPYYKRERN | KRSTQITVRF | 
    550:
    LDNPHYNKNI | RKKDPVLLLH | WWKEIVATIL | FCIIATTFIV | RRLFHPHPHR | 
    600:
    QRKESETQCQ | TENKYDSVSG | EANDSSWNDI | KNSGYISRYL | TDFEPIQCLG | 
    650:
    RGGFGVVFEA | KNKVDDCNYA | IKRIRLPNRE | LAREKVMREV | KALAKLEHPG | 
    700:
    IVRYFNAWLE | APPEKWQEKM | DEIWLKDEST | DWPLSSPSPM | DAPSVKIRRM | 
    750:
    DPFATKEHIE | IIAPSPQRSR | SFSVGISCDQ | TSSSESQFSP | LEFSGMDHED | 
    800:
    ISESVDAAYN | LQDSCLTDCD | VEDGTMDGND | EGHSFELCPS | EASPYVRSRE | 
    850:
    RTSSSIVFED | SGCDNASSKE | EPKTNRLHIG | NHCANKLTAF | KPTSSKSSSE | 
    900:
    ATLSISPPRP | TTLSLDLTKN | TTEKLQPSSP | KVYLYIQMQL | CRKENLKDWM | 
    950:
    NGRCTIEERE | RSVCLHIFLQ | IAEAVEFLHS | KGLMHRDLKP | SNIFFTMDDV | 
    1000:
    VKVGDFGLVT | AMDQDEEEQT | VLTPMPAYAR | HTGQVGTKLY | MSPEQIHGNS | 
    1050:
    YSHKVDIFSL | GLILFELLYP | FSTQMERVRT | LTDVRNLKFP | PLFTQKYPCE | 
    1100:
    YVMVQDMLSP | SPMERPEAIN | IIENAVFEDL | DFPGKTVLRQ | RSRSLSSSGT | 
    1116:
    KHSRQSNNSH | SPLPSN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    E11434r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    U11434m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Cat.:
    P11434Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 3
    Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 3

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells."
      Shi Y. , An J. , Liang J. , Hayes S.E. , Sandusky G.E. , Stramm L.E. , Yang N.N.
      J. Biol. Chem.274:5723-5730(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANTS ARG-166 AND SER-704
      tissue: Liver.
      tissue: Pancreas.
      tissue: Testis.
    2. 2.
      "Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress."
      Sood R. , Porter A.C. , Ma K. , Quilliam L.A. , Wek R.C.
      Biochem. J.346:281-293(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANTS ARG-166 AND SER-704
      tissue: Brain.
      tissue: Pancreas.
    3. 3.
      "EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome."
      Delepine M. , Nicolino M. , Barrett T. , Golamaully M. , Lathrop G.M. , Julier C.
      Nat. Genet.25:406-409(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT WRS GLN-588;VARIANT CYS-136
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-166 AND SER-704
    7. 7.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-715;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response."
      Krishnan N. , Fu C. , Pappin D.J. , Tonks N.K.
      Sci. Signal.4:RA86-RA86(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-619;DEPHOSPHORYLATION AT TYR-619
    9. 9.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1094;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response."
      Jwa M. , Chang P.
      Nat. Cell Biol.14:1223-1230(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION BY PARP16
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter