EIF2AK3 ELISA Kit for Human(Homo sapiens) | EIAab.comEIF2AK3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > EIF2AK3(Gene name) > Human

EIF2AK3 (Gene name),

Eukaryotic translation initiation factor 2-alpha kinase 3 (Protein name ), E2AK3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EIF2AK3(PEK;PERK);

Protein name:

Eukaryotic translation initiation factor 2-alpha kinase 3;

Alternative:

Pancreatic eIF2-alpha kinase(HsPEK);PRKR-like endoplasmic reticulum kinase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.

Function:

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1116

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1116:

KHSRQSNNSH | SPLPSN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.591589

SMR:

Q9NZJ5

STRING:

9606.ENSP00000307235

KEGG:

hsa:9451

MIM:

226980

Pfam:

PF00069

String:

Q9NZJ5

Uniprot:

Q9NZJ5

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ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

E11434h

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96T

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ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

E11434m

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Manual:

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96T

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ELISA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

E11434r

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

U11434h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

U11434r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

U11434m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Cat.:

P11434Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Monoclonal Antibody for Human Eukaryotic translation initiation factor 2-alpha kinase 3

Protein for Human Eukaryotic translation initiation factor 2-alpha kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells."
Shi Y. , An J. , Liang J. , Hayes S.E. , Sandusky G.E. , Stramm L.E. , Yang N.N.
J. Biol. Chem.274:5723-5730(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANTS ARG-166 AND SER-704
tissue: Liver.
tissue: Pancreas.
tissue: Testis.
2.

"Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress."
Sood R. , Porter A.C. , Ma K. , Quilliam L.A. , Wek R.C.
Biochem. J.346:281-293(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;VARIANTS ARG-166 AND SER-704
tissue: Brain.
tissue: Pancreas.
3.

"EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome."
Delepine M. , Nicolino M. , Barrett T. , Golamaully M. , Lathrop G.M. , Julier C.
Nat. Genet.25:406-409(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT WRS GLN-588;VARIANT CYS-136
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-166 AND SER-704
7.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-715;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"H2s-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response."
Krishnan N. , Fu C. , Pappin D.J. , Tonks N.K.
Sci. Signal.4:RA86-RA86(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-619;DEPHOSPHORYLATION AT TYR-619
9.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1094;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK-and IRE1alpha-mediated unfolded protein response."
Jwa M. , Chang P.
Nat. Cell Biol.14:1223-1230(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION BY PARP16
11.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-136; VAL-566 AND LEU-716

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