Protein name:
Endothelin-converting enzyme 1 (ECE-1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked.
Function:
Converts big endothelin-1 to endothelin-1.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MRGVWPPPVS | ALLSALGMST | YKRATLDEED | LVDSLSEGDA | YPNGLQVNFH |
100:
SPRSGQRCWA | ARTQVEKRLV | VLVVLLAAGL | VACLAALGIQ | YQTRSPSVCL |
150:
SEACVSVTSS | ILSSMDPTVD | PCHDFFSYAC | GGWIKANPVP | DGHSRWGTFS |
200:
NLWEHNQAII | KHLLENSTAS | VSEAERKAQV | YYRACMNETR | IEELRAKPLM |
250:
ELIERLGGWN | ITGPWAKDNF | QDTLQVVTAH | YRTSPFFSVY | VSADSKNSNS |
300:
NVIQVDQSGL | GLPSRDYYLN | KTENEKVLTG | YLNYMVQLGK | LLGGGDEEAI |
350:
RPQMQQILDF | ETALANITIP | QEKRRDEELI | YHKVTAAELQ | TLAPAINWLP |
400:
FLNTIFYPVE | INESEPIVVY | DKEYLEQIST | LINTTDRCLL | NNYMIWNLVR |
450:
KTSSFLDQRF | QDADEKFMEV | MYGTKKTCLP | RWKFCVSDTE | NNLGFALGPM |
500:
FVKATFAEDS | KSIATEIILE | IKKAFEESLS | TLKWMDEETR | KSAKEKADAI |
550:
YNMIGYPNFI | MDPKELDKVF | NDYTAVPDLY | FENAMRFFNF | SWRVTADQLR |
600:
KAPNRDQWSM | TPPMVNAYYS | PTKNEIVFPA | GILQAPFYTR | SSPKALNFGG |
650:
IGVVVGHELT | HAFDDQGREY | DKDGNLRPWW | KNSSVEAFKR | QTECMVEQYS |
700:
NYSVNGEPVN | GRHTLGENIA | DNGGLKAAYR | AYQNWVKKNG | AEHSLPTLGL |
750:
TNNQLFFLGF | AQVWCSVRTP | ESSHEGLITD | PHSPSRFRVI | GSLSNSKEFS |
770:
EHFRCPPGSP | MNPPHKCEVW |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
ELISA Kit for Human ECE-1
ELISA Kit for Human ECE-1
ELISA Kit for Human ECE-1
ELISA Kit for Human ECE-1
Polyclonal Antibody for Human ECE-1
Polyclonal Antibody for Human ECE-1
Polyclonal Antibody for Human ECE-1
Polyclonal Antibody for Human ECE-1
Monoclonal Antibody for Human ECE-1
Monoclonal Antibody for Human ECE-1
Monoclonal Antibody for Human ECE-1
Monoclonal Antibody for Human ECE-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
tissue :
Trachea .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-341
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
tissue :
Brain .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-132 (ISOFORM D);TISSUE SPECIFICITY
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-103 (ISOFORM C);FUNCTION;TISSUE SPECIFICITY
tissue :
Umbilical vein endothelial cell .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 7-770 (ISOFORM B)
tissue :
Placenta .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 713-770
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-210
tissue :
Platelet .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-166; ASN-210; ASN-270 AND ASN-316
tissue :
Liver .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-166; ASN-210; ASN-362 AND ASN-383
tissue :
Leukemic T-cell .
19.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
20.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 101-770 OF MUTANT SER-428 IN COMPLEX WITH ZINC IONS AND PHOSPHORAMIDON;COFACTOR;SUBUNIT;MUTAGENESIS OF CYS-428
22.
"A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction."
Hofstra R.M.W.
,
Valdenaire O.
,
Arch E.
,
Osinga J.
,
Kroes H.
,
Loffler B.-M.
,
Hamosh A.
,
Meijers C.
,
Buys C.H.C.M.
Am. J. Hum. Genet.64:304-308(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT HSCRCDAD CYS-754