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Index > Protein center > ECE1(Gene name) > Human
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  • ECE1 (Gene name),
  • Endothelin-converting enzyme 1 (Protein name ),  ECE1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ECE1;
    Protein name:
    Endothelin-converting enzyme 1(ECE-1);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Converts big endothelin-1 to endothelin-1.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    770
    Sequence:
    50:
    MRGVWPPPVS | ALLSALGMST | YKRATLDEED | LVDSLSEGDA | YPNGLQVNFH | 
    100:
    SPRSGQRCWA | ARTQVEKRLV | VLVVLLAAGL | VACLAALGIQ | YQTRSPSVCL | 
    150:
    SEACVSVTSS | ILSSMDPTVD | PCHDFFSYAC | GGWIKANPVP | DGHSRWGTFS | 
    200:
    NLWEHNQAII | KHLLENSTAS | VSEAERKAQV | YYRACMNETR | IEELRAKPLM | 
    250:
    ELIERLGGWN | ITGPWAKDNF | QDTLQVVTAH | YRTSPFFSVY | VSADSKNSNS | 
    300:
    NVIQVDQSGL | GLPSRDYYLN | KTENEKVLTG | YLNYMVQLGK | LLGGGDEEAI | 
    350:
    RPQMQQILDF | ETALANITIP | QEKRRDEELI | YHKVTAAELQ | TLAPAINWLP | 
    400:
    FLNTIFYPVE | INESEPIVVY | DKEYLEQIST | LINTTDRCLL | NNYMIWNLVR | 
    450:
    KTSSFLDQRF | QDADEKFMEV | MYGTKKTCLP | RWKFCVSDTE | NNLGFALGPM | 
    500:
    FVKATFAEDS | KSIATEIILE | IKKAFEESLS | TLKWMDEETR | KSAKEKADAI | 
    550:
    YNMIGYPNFI | MDPKELDKVF | NDYTAVPDLY | FENAMRFFNF | SWRVTADQLR | 
    600:
    KAPNRDQWSM | TPPMVNAYYS | PTKNEIVFPA | GILQAPFYTR | SSPKALNFGG | 
    650:
    IGVVVGHELT | HAFDDQGREY | DKDGNLRPWW | KNSSVEAFKR | QTECMVEQYS | 
    700:
    NYSVNGEPVN | GRHTLGENIA | DNGGLKAAYR | AYQNWVKKNG | AEHSLPTLGL | 
    750:
    TNNQLFFLGF | AQVWCSVRTP | ESSHEGLITD | PHSPSRFRVI | GSLSNSKEFS | 
    770:
    EHFRCPPGSP | MNPPHKCEVW | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    SMR:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human ECE-1
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    ELISA Kit for Human ECE-1
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    ELISA Kit for Human ECE-1
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    ELISA Kit for Human ECE-1
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    E9194h
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    CLIA Kit for Human ECE-1
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    CLIA Kit for Human ECE-1
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    U9194m
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    Packing:
    96T
    CLIA Kit for Human ECE-1
    Cat.:
    U9194b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human ECE-1
    Cat.:
    U9194h
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Human ECE-1
    Polyclonal Antibody for Human ECE-1
    Cat.:
    P9194Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ECE-1
    Cat.:
    P9194Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ECE-1
    Monoclonal Antibody for Human ECE-1
    Monoclonal Antibody for Human ECE-1
    Monoclonal Antibody for Human ECE-1
    Monoclonal Antibody for Human ECE-1
    Protein for Human ECE-1
    Protein for Human ECE-1
    Protein for Human ECE-1
    Protein for Human ECE-1

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    References
    1. 1.
      "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2."
      Yorimitsu K. , Moroi K. , Inagaki N. , Saito T. , Masuda Y. , Masaki T. , Seino S. , Kimura S.
      Biochem. Biophys. Res. Commun.208:721-727(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B)
    2. 2.
      "Cloning and functional expression of human endothelin-converting enzyme cDNA."
      Shimada K. , Matsushita Y. , Wakabayashi K. , Takahashi M. , Matsubara A. , Iijima Y. , Tanzawa K.
      Biochem. Biophys. Res. Commun.207:807-812(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
    3. 3.
      "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)."
      Valdenaire O. , Rohrbacher E. , Mattei M.-G.
      J. Biol. Chem.270:29794-29798(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B)
      tissue: Placenta.
    4. 4.
      "Human endothelin-converting enzyme-1c."
      Takayanagi R.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C)
      tissue: Umbilical vein endothelial cell.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B)
      tissue: Trachea.
    6. 6.
      NIEHS SNPs program
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-341
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
      tissue: Brain.
    10. 10.
      "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter."
      Valdenaire O. , Lepailleur-Enouf D. , Egidy G. , Thouard A. , Barret A. , Vranckx R. , Tougard C. , Michel J.-B.
      Eur. J. Biochem.264:341-349(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-132 (ISOFORM D);TISSUE SPECIFICITY
    11. 11.
      "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations."
      Schweizer A. , Valdenaire O. , Nelboeck P. , Deuschle U. , Dumas Milne Edwards J.B. , Stumpf J.G. , Loeffler B.-M.
      Biochem. J.328:871-877(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-103 (ISOFORM C);FUNCTION;TISSUE SPECIFICITY
      tissue: Umbilical vein endothelial cell.
    12. 12.
      "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)."
      Schmidt M. , Kroeger B. , Jacob E. , Seulberger H. , Subkowski T. , Otter R. , Meyer T. , Schmalzing G. , Hillen H.
      FEBS Lett.356:238-243(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-770 (ISOFORM B)
      tissue: Placenta.
    13. 13.
      "Characterization of the human endothelin converting enzyme-1 gene (ECE-1): genomic structure and chromosomal localization."
      Flowers M.A. , Tai S.C. , Baluyut C.A. , Cheung A.H. , Kau C.L. , Wong G.K.T. , Marsden P.A.
      Submitted (1997-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 713-770
    14. 14.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-210
      tissue: Platelet.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-166; ASN-210; ASN-270 AND ASN-316
      tissue: Liver.
    18. 18.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-166; ASN-210; ASN-362 AND ASN-383
      tissue: Leukemic T-cell.
    19. 19.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-25;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Structure of human endothelin-converting enzyme I complexed with phosphoramidon."
      Schulz H. , Dale G.E. , Karimi-Nejad Y. , Oefner C.
      J. Mol. Biol.385:178-187(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 101-770 OF MUTANT SER-428 IN COMPLEX WITH ZINC IONS AND PHOSPHORAMIDON;COFACTOR;SUBUNIT;MUTAGENESIS OF CYS-428
    22. 22.
      "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction."
      Hofstra R.M.W. , Valdenaire O. , Arch E. , Osinga J. , Kroes H. , Loffler B.-M. , Hamosh A. , Meijers C. , Buys C.H.C.M.
      Am. J. Hum. Genet.64:304-308(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HSCRCDAD CYS-754
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