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Index > Protein center > EDEM2(Gene name) > Human
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  • EDEM2 (Gene name),
  • ER degradation-enhancing alpha-mannosidase-like 2 (Protein name ),  EDEM2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EDEM2(UNQ573/PRO1135;C20orf31;C20orf49);
    Protein name:
    ER degradation-enhancing alpha-mannosidase-like 2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
    Subcellular Location:
    Secreted Endoplasmic reticulum lumen
    Protein Attributes:
    Sequence length:
    578
    Sequence:
    50:
    MPFRLLIPLG | LLCALLPQHH | GAPGPDGSAP | DPAHYRERVK | AMFYHAYDSY | 
    100:
    LENAFPFDEL | RPLTCDGHDT | WGSFSLTLID | ALDTLLILGN | VSEFQRVVEV | 
    150:
    LQDSVDFDID | VNASVFETNI | RVVGGLLSAH | LLSKKAGVEV | EAGWPCSGPL | 
    200:
    LRMAEEAARK | LLPAFQTPTG | MPYGTVNLLH | GVNPGETPVT | CTAGIGTFIV | 
    250:
    EFATLSSLTG | DPVFEDVARV | ALMRLWESRS | DIGLVGNHID | VLTGKWVAQD | 
    300:
    AGIGAGVDSY | FEYLVKGAIL | LQDKKLMAMF | LEYNKAIRNY | TRFDDWYLWV | 
    350:
    QMYKGTVSMP | VFQSLEAYWP | GLQSLIGDID | NAMRTFLNYY | TVWKQFGGLP | 
    400:
    EFYNIPQGYT | VEKREGYPLR | PELIESAMYL | YRATGDPTLL | ELGRDAVESI | 
    450:
    EKISKVECGF | ATIKDLRDHK | LDNRMESFFL | AETVKYLYLL | FDPTNFIHNN | 
    500:
    GSTFDAVITP | YGECILGAGG | YIFNTEAHPI | DPAALHCCQR | LKEEQWEVED | 
    550:
    LMREFYSLKR | SRSKFQKNTV | SSGPWEPPAR | PGTLFSPENH | DQARERKPAK | 
    578:
    QKVPLLSCPS | QPFTSKLALL | GQVFLDSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ER degradation-enhancing alpha-mannosidase-like 2
    CLIA Kit for Human ER degradation-enhancing alpha-mannosidase-like 2
    Polyclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 2
    Monoclonal Antibody for Human ER degradation-enhancing alpha-mannosidase-like 2
    Protein for Human ER degradation-enhancing alpha-mannosidase-like 2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
      tissue: Thyroid.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-456
      tissue: Colon.
      tissue: Skin.
    7. 7.
      "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins."
      Mast S.W. , Diekman K. , Karaveg K. , Davis A. , Sifers R.N. , Moremen K.W.
      Glycobiology15:421-436(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
    8. 8.
      "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation."
      Olivari S. , Galli C. , Alanen H. , Ruddock L. , Molinari M.
      J. Biol. Chem.280:2424-2428(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION
    9. 9.
      "EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step."
      Ninagawa S. , Okada T. , Sumitomo Y. , Kamiya Y. , Kato K. , Horimoto S. , Ishikawa T. , Takeda S. , Sakuma T. , Yamamoto T. , Mori K.
      J. Cell Biol.206:347-356(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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