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Index > Protein center > GFM1(Gene name) > Human
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  • GFM1 (Gene name),
  • Elongation factor G, mitochondrial (Protein name ),  EFGM_HUMAN from NCBI database.
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  • Gene name:
    GFM1(EFG;EFG1;GFM);
    Protein name:
    Elongation factor G, mitochondrial(EF-Gmt);
    Alternative:
    Elongation factor G1(hEFG1);Elongation factor G 1, mitochondrial(mEF-G 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    751
    Sequence:
    50:
    MRLLGAAAVA | ALGRGRAPAS | LGWQRKQVNW | KACRWSSSGV | IPNEKIRNIG | 
    100:
    ISAHIDSGKT | TLTERVLYYT | GRIAKMHEVK | GKDGVGAVMD | SMELERQRGI | 
    150:
    TIQSAATYTM | WKDVNINIID | TPGHVDFTIE | VERALRVLDG | AVLVLCAVGG | 
    200:
    VQCQTMTVNR | QMKRYNVPFL | TFINKLDRMG | SNPARALQQM | RSKLNHNAAF | 
    250:
    MQIPMGLEGN | FKGIVDLIEE | RAIYFDGDFG | QIVRYGEIPA | ELRAAATDHR | 
    300:
    QELIECVANS | DEQLGEMFLE | EKIPSISDLK | LAIRRATLKR | SFTPVFLGSA | 
    350:
    LKNKGVQPLL | DAVLEYLPNP | SEVQNYAILN | KEDDSKEKTK | ILMNSSRDNS | 
    400:
    HPFVGLAFKL | EVGRFGQLTY | VRSYQGELKK | GDTIYNTRTR | KKVRLQRLAR | 
    450:
    MHADMMEDVE | EVYAGDICAL | FGIDCASGDT | FTDKANSGLS | MESIHVPDPV | 
    500:
    ISIAMKPSNK | NDLEKFSKGI | GRFTREDPTF | KVYFDTENKE | TVISGMGELH | 
    550:
    LEIYAQRLER | EYGCPCITGK | PKVAFRETIT | APVPFDFTHK | KQSGGAGQYG | 
    600:
    KVIGVLEPLD | PEDYTKLEFS | DETFGSNIPK | QFVPAVEKGF | LDACEKGPLS | 
    650:
    GHKLSGLRFV | LQDGAHHMVD | SNEISFIRAG | EGALKQALAN | ATLCILEPIM | 
    700:
    AVEVVAPNEF | QGQVIAGINR | RHGVITGQDG | VEDYFTLYAD | VPLNDMFGYS | 
    750:
    TELRSCTEGK | GEYTMEYSRY | QPCLPSTQED | VINKYLEATG | QLPVKKGKAK | 
    751:
    N
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    UniGene:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human EF-Gmt
    Cat.:
    E9702h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human EF-Gmt
    Cat.:
    E9702m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human EF-Gmt
    Cat.:
    E9702r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human EF-Gmt
    Cat.:
    U9702h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human EF-Gmt
    Cat.:
    U9702r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human EF-Gmt
    Cat.:
    U9702m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human EF-Gmt
    Cat.:
    P9702Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human EF-Gmt
    Cat.:
    P9702Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human EF-Gmt
    Monoclonal Antibody for Human EF-Gmt
    Monoclonal Antibody for Human EF-Gmt
    Monoclonal Antibody for Human EF-Gmt
    Protein for Human EF-Gmt
    Protein for Human EF-Gmt
    Protein for Human EF-Gmt

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    Linearity
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    References
    1. 1.
      "Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and gfm, and mapping of GFM to human chromosome 3q25.1-q26.2."
      Gao J. , Yu L. , Zhang P. , Jiang J. , Chen J. , Peng J. , Wei Y. , Zhao S.
      Genomics74:109-114(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution."
      Hammarsund M. , Wilson W. , Corcoran M. , Merup M. , Einhorn S. , Grander D. , Sangfelt O.
      Hum. Genet.109:542-550(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-751 (ISOFORM 2);VARIANT ILE-215
      tissue: Placenta.
      tissue: Tongue.
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Duodenum.
    7. 7.
      "Expression and characterization of isoform 1 of human mitochondrial elongation factor G."
      Bhargava K. , Templeton P. , Spremulli L.L.
      Protein Expr. Purif.37:368-376(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POTENTIAL TRANSIT PEPTIDE
    8. 8.
      "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis."
      Tsuboi M. , Morita H. , Nozaki Y. , Akama K. , Ueda T. , Ito K. , Nierhaus K.H. , Takeuchi N.
      Mol. Cell35:502-510(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PATHWAY
    9. 9.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-175;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COXPD1 SER-174
    12. 12.
      "Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu."
      Valente L. , Tiranti V. , Marsano R.M. , Malfatti E. , Fernandez-Vizarra E. , Donnini C. , Mereghetti P. , De Gioia L. , Burlina A. , Castellan C. , Comi G.P. , Savasta S. , Ferrero I. , Zeviani M.
      Am. J. Hum. Genet.80:44-58(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COXPD1 ARG-496
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