Efna1 ELISA Kit for Mouse(Mus musculus) | EIAab.comEfna1 ELISA Kit for Mouse(Mus musculus)

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Efna1 (Gene name),

Ephrin-A1 (Protein name ), EFNA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Efna1(Epgl1;Epl1;Lerk1);

Protein name:

Ephrin-A1;

Alternative:

Immediate early response protein B61;EPH-related receptor tyrosine kinase ligand 1(LERK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.

Function:

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Subcellular Location:

Ephrin-A1, secreted form Secreted

Protein Attributes:

Sequence length:

205

Sequence:

50:

100:

150:

200:

205:

LLQSQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00812

String:

P52793

KEGG:

mmu:13636

SMR:

P52793

STRING:

10090.ENSMUSP00000029566

UniGene:

Mm.15675

Uniprot:

P52793

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ELISA Kit for Mouse Ephrin-A1

Cat.:

E1422h

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96T

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ELISA Kit for Mouse Ephrin-A1

Cat.:

E1422m

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96T

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ELISA Kit for Mouse Ephrin-A1

Cat.:

E1422p

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96T

ELISA Kit for Mouse Ephrin-A1

Cat.:

E1422r

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96T

ELISA Kit for Mouse Ephrin-A1

Cat.:

E1422b

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96T

CLIA Kit for Mouse Ephrin-A1

Cat.:

U1422h

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96T

CLIA Kit for Mouse Ephrin-A1

Cat.:

U1422r

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96T

CLIA Kit for Mouse Ephrin-A1

Cat.:

U1422m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Ephrin-A1

Cat.:

U1422b

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96T

CLIA Kit for Mouse Ephrin-A1

Cat.:

U1422p

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96T

Polyclonal Antibody for Mouse Ephrin-A1

Cat.:

P1422Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Ephrin-A1

Cat.:

P1422Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Ephrin-A1

Cat.:

P1422Rb-m

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Monoclonal Antibody for Mouse Ephrin-A1

Protein for Mouse Ephrin-A1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and expression of rat and mouse B61 gene: implications on organogenesis."
Takahashi H. , Ikeda T.
Oncogene11:879-883(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: ICR.
2.

Morris J.C. , Ciarletta A. , Morris G.E. , Giannotti J. , Caruso A. , Hammett D.J. , Finnerty H. , Turner K. , Wood C.R.
Submitted (1995-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
3.

"Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis."
Flenniken A.M. , Gale N.W. , Yancopoulos G.D. , Wilkinson D.G.
Dev. Biol.179:382-401(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Mammary gland.
5.

"Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
Hunter S.G. , Zhuang G. , Brantley-Sieders D.M. , Swat W. , Cowan C.W. , Chen J.
Mol. Cell. Biol.26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
Fu W.Y. , Chen Y. , Sahin M. , Zhao X.S. , Shi L. , Bikoff J.B. , Lai K.O. , Yung W.H. , Fu A.K. , Greenberg M.E. , Ip N.Y.
Nat. Neurosci.10:67-76(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DENDRITIC SPINE MORPHOGENESIS
7.

"Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase."
Fang W.B. , Brantley-Sieders D.M. , Hwang Y. , Ham A.-J.L. , Chen J.
J. Biol. Chem.283:16017-16026(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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