"Mapping, characterization, and expression analysis of the SM-20 human homologue, C1orf12, and identification of a novel related gene, SCAND2."
Dupuy D. , Aubert I. , Duperat V.G. , Petit J. , Taine L. , Stef M. , Bloch B. , Arveiler B.
Genomics69:348-354(2000) [PubMed] [Europe PMC] [Abstract]

"Characterization and comparative analysis of the EGLN gene family."
Taylor M.S.
Gene275:125-132(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor."
Hirsila M. , Koivunen P. , Gunzler V. , Kivirikko K.I. , Myllyharju J.
J. Biol. Chem.278:30772-30780(2003) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , Schupp I. more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , Atkinson A. , Cooper R. , Jones C. , Hall R.E. , Andrews T.D. , Lloyd C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Anderson F. , Andrew R.W. , Ashwell R.I.S. , Aubin K. , Babbage A.K. , Bagguley C.L. , Bailey J. , Beasley H. , Bethel G. , Bird C.P. , Bray-Allen S. , Brown J.Y. , Brown A.J. , Buckley D. , Burton J. , Bye J. , Carder C. , Chapman J.C. , Clark S.Y. , Clarke G. , Clee C. , Cobley V. , Collier R.E. , Corby N. , Coville G.J. , Davies J. , Deadman R. , Dunn M. , Earthrowl M. , Ellington A.G. , Errington H. , Frankish A. , Frankland J. , French L. , Garner P. , Garnett J. , Gay L. , Ghori M.R.J. , Gibson R. , Gilby L.M. , Gillett W. , Glithero R.J. , Grafham D.V. , Griffiths C. , Griffiths-Jones S. , Grocock R. , Hammond S. , Harrison E.S.I. , Hart E. , Haugen E. , Heath P.D. , Holmes S. , Holt K. , Howden P.J. , Hunt A.R. , Hunt S.E. , Hunter G. , Isherwood J. , James R. , Johnson C. , Johnson D. , Joy A. , Kay M. , Kershaw J.K. , Kibukawa M. , Kimberley A.M. , King A. , Knights A.J. , Lad H. , Laird G. , Lawlor S. , Leongamornlert D.A. , Lloyd D.M. , Loveland J. , Lovell J. , Lush M.J. , Lyne R. , Martin S. , Mashreghi-Mohammadi M. , Matthews L. , Matthews N.S.W. , McLaren S. , Milne S. , Mistry S. , Moore M.J.F. , Nickerson T. , O'Dell C.N. , Oliver K. , Palmeiri A. , Palmer S.A. , Parker A. , Patel D. , Pearce A.V. , Peck A.I. , Pelan S. , Phelps K. , Phillimore B.J. , Plumb R. , Rajan J. , Raymond C. , Rouse G. , Saenphimmachak C. , Sehra H.K. , Sheridan E. , Shownkeen R. , Sims S. , Skuce C.D. , Smith M. , Steward C. , Subramanian S. , Sycamore N. , Tracey A. , Tromans A. , Van Helmond Z. , Wall M. , Wallis J.M. , White S. , Whitehead S.L. , Wilkinson J.E. , Willey D.L. , Williams H. , Wilming L. , Wray P.W. , Wu Z. , Coulson A. , Vaudin M. , Sulston J.E. , Durbin R.M. , Hubbard T. , Wooster R. , Dunham I. , Carter N.P. , McVean G. , Ross M.T. , Harrow J. , Olson M.V. , Beck S. , Rogers J. , Bentley D.R. more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
Yu W.-Q. , Sun B.-Z. , Chai Y.-B. , Zhu F. , Liu X.-S. , Li Z. , Lu F. , Yan W. , Yang H. , Zhao Z.-L.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

"HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus."
Semenza G.L.
Cell107:1-3(2001) [PubMed] [Europe PMC] [Abstract]

"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation."
Epstein A.C.R. , Gleadle J.M. , McNeill L.A. , Hewitson K.S. , O'Rourke J. , Mole D.R. , Mukherji M. , Metzen E. , Wilson M.I. , Dhanda A. , Tian Y.M. , Masson N. , Hamilton D.L. , Jaakkola P. , Barstead R. , Hodgkin J. , Maxwell P.H. , Pugh C.W. , Schofield C.J. , Ratcliffe P.J. more...
Cell107:43-54(2001) [PubMed] [Europe PMC] [Abstract]

"Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3."
Huang J. , Zhao Q. , Mooney S.M. , Lee F.S.
J. Biol. Chem.277:39792-39800(2002) [PubMed] [Europe PMC] [Abstract]

"Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor."
Ivan M. , Haberberger T. , Gervasi D.C. , Michelson K.S. , Guenzler V. , Kondo K. , Yang H. , Sorokina I. , Conaway R.C. , Conaway J.W. , Kaelin W.G. Jr.
Proc. Natl. Acad. Sci. U.S.A.99:13459-13464(2002) [PubMed] [Europe PMC] [Abstract]

"Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors."
Oehme F. , Ellinghaus P. , Kolkhof P. , Smith T.J. , Ramakrishnan S. , Huetter J. , Schramm M. , Flamme I.
Biochem. Biophys. Res. Commun.296:343-349(2002) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells."
Cioffi C.L. , Qin Liu X. , Kosinski P.A. , Garay M. , Bowen B.R.
Biochem. Biophys. Res. Commun.303:947-953(2003) [PubMed] [Europe PMC] [Abstract]

"Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing."
Metzen E. , Berchner-Pfannschmidt U. , Stengel P. , Marxsen J.H. , Stolze I. , Klinger M. , Huang W.Q. , Wotzlaw C. , Hellwig-Burgel T. , Jelkmann W. , Acker H. , Fandrey J.
J. Cell Sci.116:1319-1326(2003) [PubMed] [Europe PMC] [Abstract]

"Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor."
Appelhoff R.J. , Tian Y.M. , Raval R.R. , Turley H. , Harris A.L. , Pugh C.W. , Ratcliffe P.J. , Gleadle J.M.
J. Biol. Chem.279:38458-38465(2004) [PubMed] [Europe PMC] [Abstract]

"The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)."
Ozer A. , Wu L.C. , Bruick R.K.
Proc. Natl. Acad. Sci. U.S.A.102:7481-7486(2005) [PubMed] [Europe PMC] [Abstract]

"Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases."
Flashman E. , Bagg E.A. , Chowdhury R. , Mecinovic J. , Loenarz C. , McDonough M.A. , Hewitson K.S. , Schofield C.J.
J. Biol. Chem.283:3808-3815(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2."
Steinhoff A. , Pientka F.K. , Mockel S. , Kettelhake A. , Hartmann E. , Kohler M. , Depping R.
Biochem. Biophys. Res. Commun.387:705-711(2009) [PubMed] [Europe PMC] [Abstract]

"Role of the intracellular localization of HIF-prolyl hydroxylases."
Yasumoto K. , Kowata Y. , Yoshida A. , Torii S. , Sogawa K.
Biochim. Biophys. Acta1793:792-797(2009) [PubMed] [Europe PMC] [Abstract]

"Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline."
Furlow P.W. , Percy M.J. , Sutherland S. , Bierl C. , McMullin M.F. , Master S.R. , Lappin T.R. , Lee F.S.
J. Biol. Chem.284:9050-9058(2009) [PubMed] [Europe PMC] [Abstract]

"Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen."
Flashman E. , Hoffart L.M. , Hamed R.B. , Bollinger J.M. Jr. , Krebs C. , Schofield C.J.
FEBS J.277:4089-4099(2010) [PubMed] [Europe PMC] [Abstract]

"Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data."
Bigham A. , Bauchet M. , Pinto D. , Mao X. , Akey J.M. , Mei R. , Scherer S.W. , Julian C.G. , Wilson M.J. , Lopez Herraez D. , Brutsaert T. , Parra E.J. , Moore L.G. , Shriver M.D.
PLoS Genet.6:E1001116-E1001116(2010) [PubMed] [Europe PMC] [Abstract]

"Genetic evidence for high-altitude adaptation in Tibet."
Simonson T.S. , Yang Y. , Huff C.D. , Yun H. , Qin G. , Witherspoon D.J. , Bai Z. , Lorenzo F.R. , Xing J. , Jorde L.B. , Prchal J.T. , Ge R.
Science329:72-75(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer."
Su Y. , Loos M. , Giese N. , Metzen E. , Buchler M.W. , Friess H. , Kornberg A. , Buchler P.
Cancer118:960-972(2012) [PubMed] [Europe PMC] [Abstract]

"The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."
Foxler D.E. , Bridge K.S. , James V. , Webb T.M. , Mee M. , Wong S.C. , Feng Y. , Constantin-Teodosiu D. , Petursdottir T.E. , Bjornsson J. , Ingvarsson S. , Ratcliffe P.J. , Longmore G.D. , Sharp T.V.
Nat. Cell Biol.14:201-208(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation."
Seo K.S. , Park J.H. , Heo J.Y. , Jing K. , Han J. , Min K.N. , Kim C. , Koh G.Y. , Lim K. , Kang G.Y. , Uee Lee J. , Yim Y.H. , Shong M. , Kwak T.H. , Kweon G.R.
Oncogene0:0-0(2014) [PubMed] [Europe PMC] [Abstract]

"Cellular oxygen sensing: crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)."
McDonough M.A. , Li V. , Flashman E. , Chowdhury R. , Mohr C. , Lienard B.M.R. , Zondlo J. , Oldham N.J. , Clifton I.J. , Lewis J. , McNeill L.A. , Kurzeja R.J. , Hewitson K.S. , Yang E. , Jordan S. , Syed R.S. , Schofield C.J.
Proc. Natl. Acad. Sci. U.S.A.103:9814-9819(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases."
Chowdhury R. , McDonough M.A. , Mecinovic J. , Loenarz C. , Flashman E. , Hewitson K.S. , Domene C. , Schofield C.J.
Structure17:981-989(2009) [PubMed] [Europe PMC] [Abstract]

"Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)."
Chowdhury R. , Flashman E. , Mecinovic J. , Kramer H.B. , Kessler B.M. , Frapart Y.M. , Boucher J.L. , Clifton I.J. , McDonough M.A. , Schofield C.J.
J. Mol. Biol.410:268-279(2011) [PubMed] [Europe PMC] [Abstract]

"A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis."
Percy M.J. , Zhao Q. , Flores A. , Harrison C. , Lappin T.R. , Maxwell P.H. , McMullin M.F. , Lee F.S.
Proc. Natl. Acad. Sci. U.S.A.103:654-659(2006) [PubMed] [Europe PMC] [Abstract]

"A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove."
Percy M.J. , Furlow P.W. , Beer P.A. , Lappin T.R.J. , McMullin M.F. , Lee F.S.
Blood110:2193-2196(2007) [PubMed] [Europe PMC] [Abstract]

"Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing."
Song D. , Li L.S. , Arsenault P.R. , Tan Q. , Bigham A.W. , Heaton-Johnson K.J. , Master S.R. , Lee F.S.
J. Biol. Chem.289:14656-14665(2014) [PubMed] [Europe PMC] [Abstract]

"A genetic mechanism for Tibetan high-altitude adaptation."
Lorenzo F.R. , Huff C. , Myllymaeki M. , Olenchock B. , Swierczek S. , Tashi T. , Gordeuk V. , Wuren T. , Ri-Li G. , McClain D.A. , Khan T.M. , Koul P.A. , Guchhait P. , Salama M.E. , Xing J. , Semenza G.L. , Liberzon E. , Wilson A. , Simonson T.S. , Jorde L.B. , Kaelin W.G. Jr. , Koivunen P. , Prchal J.T. more...
Nat. Genet.46:951-956(2014) [PubMed] [Europe PMC] [Abstract]