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Index > Protein center > EIF2A(Gene name) > Human
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  • EIF2A (Gene name),
  • Eukaryotic translation initiation factor 2A (Protein name ),  EIF2A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF2A(CDA02;MSTP004;MSTP089);
    Protein name:
    Eukaryotic translation initiation factor 2A(eIF-2A);
    Alternative:
    65 kDa eukaryotic translation initiation factor 2A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    585
    Sequence:
    50:
    MAPSTPLLTV | RGSEGLYMVN | GPPHFTESTV | FPRESGKNCK | VCIFSKDGTL | 
    100:
    FAWGNGEKVN | IISVTNKGLL | HSFDLLKAVC | LEFSPKNTVL | ATWQPYTTSK | 
    150:
    DGTAGIPNLQ | LYDVKTGTCL | KSFIQKKMQN | WCPSWSEDET | LCARNVNNEV | 
    200:
    HFFENNNFNT | IANKLHLQKI | NDFVLSPGPQ | PYKVAVYVPG | SKGAPSFVRL | 
    250:
    YQYPNFAGPH | AALANKSFFK | ADKVTMLWNK | KATAVLVIAS | TDVDKTGASY | 
    300:
    YGEQTLHYIA | TNGESAVVQL | PKNGPIYDVV | WNSSSTEFCA | VYGFMPAKAT | 
    350:
    IFNLKCDPVF | DFGTGPRNAA | YYSPHGHILV | LAGFGNLRGQ | MEVWDVKNYK | 
    400:
    LISKPVASDS | TYFAWCPDGE | HILTATCAPR | LRVNNGYKIW | HYTGSILHKY | 
    450:
    DVPSNAELWQ | VSWQPFLDGI | FPAKTITYQA | VPSEVPNEEP | KVATAYRPPA | 
    500:
    LRNKPITNSK | LHEEEPPQNM | KPQSGNDKPL | SKTALKNQRK | HEAKKAAKQE | 
    550:
    ARSDKSPDLA | PTPAPQSTPR | NTVSQSISGD | PEIDKKIKNL | KKKLKAIEQL | 
    585:
    KEQAATGKQL | EKNQLEKIQK | ETALLQELED | LELGI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human eIF-2A
    ELISA Kit for Human eIF-2A
    ELISA Kit for Human eIF-2A
    CLIA Kit for Human eIF-2A
    CLIA Kit for Human eIF-2A
    CLIA Kit for Human eIF-2A
    Polyclonal Antibody for Human eIF-2A
    Polyclonal Antibody for Human eIF-2A
    Polyclonal Antibody for Human eIF-2A
    Monoclonal Antibody for Human eIF-2A
    Monoclonal Antibody for Human eIF-2A
    Monoclonal Antibody for Human eIF-2A
    Protein for Human eIF-2A
    Protein for Human eIF-2A
    Protein for Human eIF-2A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of mammalian eIF2A and identification of the yeast homolog."
      Zoll W.L. , Horton L.E. , Komar A.A. , Hensold J.O. , Merrick W.C.
      J. Biol. Chem.277:37079-37087(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;VARIANT SER-97
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4);VARIANT SER-97
      tissue: Cerebellum.
      tissue: Embryo.
    3. 3.
      "A novel gene expressed in human pheochromocytoma."
      Li Y. , Huang Q. , Peng Y. , Song H. , Yu Y. , Xu S. , Ren S. , Chen Z. , Han Z.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-97
      tissue: Pheochromocytoma.
    4. 4.
      Liu B. , Song L. , Sheng H. , Qin B.M. , Liu Y.Q. , Zhao B. , Wang X.Y. , Zhang Q. , Ji X.Y. , Liu B.H. , Lu H. , Xu H.S. , Chen J.Z. , Cai M.Q. , Zheng W.Y. , Teng C.Y. , Liu Q. , Yu L.T. , more...
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-585 (ISOFORM 1);VARIANT SER-97
      tissue: Aorta.
      tissue: Heart.
    5. 5.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-97
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LYS-582
      tissue: Lymph.
    8. 8.
      Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11; 184-192 AND 506-520;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    9. 9.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506; SER-517 AND THR-518;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND THR-518;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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