Gene name:
Elf3 (Ert;Esx;Jen) ;
Protein name:
ETS-related transcription factor Elf-3 ;
Alternative:
Epithelial-restricted with serine box ;E74-like factor 3 ;Epithelium-specific Ets transcription factor 1 (ESE-1) ;Epithelium-restricted Ets protein ESX ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.
Function:
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MAATCEISNV | FSNYFNAMYS | SEDPTLAPAP | PTTFGTEDLV | LTLNNQQMTL |
100:
EGPGPQTRSQ | RDRTDPLAVL | HLAEKASWTS | ERPQFWSKTQ | VLEWISYQVE |
150:
KNKYDASSID | FSRCDMDGAT | LCSCALEELR | LVFGPLGDQL | HAQLRDLTSN |
200:
SSDELSWIIE | LLEKDGMSFQ | ESLGDSGPFD | QGSPFAQELL | DDGRQASPYY |
250:
CSTYGPGAPS | PGSSDVSTAR | TATPQSSHAS | DSGGSDVDLD | LTESKVFPRD |
300:
GFPDYKKGEP | KHGKRKRGRP | RKLSKEYWDC | LEGKKSKHAP | RGTHLWEFIR |
350:
DILIHPELNE | GLMKWENRHE | GVFKFLRSEA | VAQLWGQKKK | NSNMTYEKLS |
391:
RAMRYYYKRE | ILERVDGRRL | VYKFGKNSSG | WKEEEVGESR | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse ETS-related transcription factor Elf-3
ELISA Kit for Mouse ETS-related transcription factor Elf-3
ELISA Kit for Mouse ETS-related transcription factor Elf-3
CLIA Kit for Mouse ETS-related transcription factor Elf-3
CLIA Kit for Mouse ETS-related transcription factor Elf-3
CLIA Kit for Mouse ETS-related transcription factor Elf-3
Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
Protein for Mouse ETS-related transcription factor Elf-3
Protein for Mouse ETS-related transcription factor Elf-3
Protein for Mouse ETS-related transcription factor Elf-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
tissue :
Lung .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Eye .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE;INDUCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF ASP-153 AND LEU-162
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;MUTAGENESIS OF 264-LYS--ARG-267; 269-ARG--LYS-272 AND 338-LYS--LYS-340