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Index > Protein center > Elf3(Gene name) > Mouse
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  • Elf3 (Gene name),
  • ETS-related transcription factor Elf-3 (Protein name ),  ELF3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Elf3(Ert;Esx;Jen);
    Protein name:
    ETS-related transcription factor Elf-3;
    Alternative:
    Epithelial-restricted with serine box;E74-like factor 3;Epithelium-specific Ets transcription factor 1(ESE-1);Epithelium-restricted Ets protein ESX;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.
    Function:
    Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    391
    Sequence:
    50:
    MAATCEISNV | FSNYFNAMYS | SEDPTLAPAP | PTTFGTEDLV | LTLNNQQMTL | 
    100:
    EGPGPQTRSQ | RDRTDPLAVL | HLAEKASWTS | ERPQFWSKTQ | VLEWISYQVE | 
    150:
    KNKYDASSID | FSRCDMDGAT | LCSCALEELR | LVFGPLGDQL | HAQLRDLTSN | 
    200:
    SSDELSWIIE | LLEKDGMSFQ | ESLGDSGPFD | QGSPFAQELL | DDGRQASPYY | 
    250:
    CSTYGPGAPS | PGSSDVSTAR | TATPQSSHAS | DSGGSDVDLD | LTESKVFPRD | 
    300:
    GFPDYKKGEP | KHGKRKRGRP | RKLSKEYWDC | LEGKKSKHAP | RGTHLWEFIR | 
    350:
    DILIHPELNE | GLMKWENRHE | GVFKFLRSEA | VAQLWGQKKK | NSNMTYEKLS | 
    391:
    RAMRYYYKRE | ILERVDGRRL | VYKFGKNSSG | WKEEEVGESR | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ETS-related transcription factor Elf-3
    ELISA Kit for Mouse ETS-related transcription factor Elf-3
    ELISA Kit for Mouse ETS-related transcription factor Elf-3
    CLIA Kit for Mouse ETS-related transcription factor Elf-3
    CLIA Kit for Mouse ETS-related transcription factor Elf-3
    CLIA Kit for Mouse ETS-related transcription factor Elf-3
    Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Polyclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Monoclonal Antibody for Mouse ETS-related transcription factor Elf-3
    Protein for Mouse ETS-related transcription factor Elf-3
    Protein for Mouse ETS-related transcription factor Elf-3
    Protein for Mouse ETS-related transcription factor Elf-3

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    References
    1. 1.
      "A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer."
      Tymms M.J. , Ng A.Y.N. , Thomas R.S. , Schutte B.C. , Zhou J. , Eyre H.J. , Sutherland G.R. , Seth A. , Rosenberg M. , Papas T. , Debouck C. , Kola I.
      Oncogene15:2449-2462(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
      tissue: Lung.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Eye.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    4. 4.
      "The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution."
      Neve R. , Chang C.-H. , Scott G.K. , Wong A. , Friis R.R. , Hynes N.E. , Benz C.C.
      FASEB J.12:1541-1550(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;INDUCTION
    5. 5.
      "Ets family transcription factor ESE-1 is expressed in corneal epithelial cells and is involved in their differentiation."
      Yoshida N. , Yoshida S. , Araie M. , Handa H. , Nabeshima Y.
      Mech. Dev.97:27-34(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
    6. 6.
      "Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium."
      Ng A.-Y.N. , Waring P. , Ristevski S. , Wang C. , Wilson T. , Pritchard M. , Hertzog P. , Kola I.
      Gastroenterology122:1455-1466(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
      Kim J.-H. , Wilder P.J. , Hou J. , Nowling T. , Rizzino A.
      J. Biol. Chem.277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-153 AND LEU-162
    8. 8.
      "The role of ETS transcription factors in transcription and development of mouse preimplantation embryos."
      Kageyama S. , Liu H. , Nagata M. , Aoki F.
      Biochem. Biophys. Res. Commun.344:675-679(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor."
      Do H.-J. , Song H. , Yang H.-M. , Kim D.-K. , Kim N.-H. , Kim J.-H. , Cha K.-Y. , Chung H.-M. , Kim J.-H.
      FEBS Lett.580:1865-1871(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 264-LYS--ARG-267; 269-ARG--LYS-272 AND 338-LYS--LYS-340
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