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Index > Protein center > ELF4(Gene name) > Human
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  • ELF4 (Gene name),
  • ETS-related transcription factor Elf-4 (Protein name ),  ELF4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ELF4(ELFR;MEF);
    Protein name:
    ETS-related transcription factor Elf-4;
    Alternative:
    Myeloid Elf-1-like factor;E74-like factor 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.
    Function:
    Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway.
    Subcellular Location:
    Nucleus PML body Accumulation into PML nuclear bodies is mediated by PML.
    Protein Attributes:
    Sequence length:
    663
    Sequence:
    50:
    MAITLQPSDL | IFEFASNGMD | DDIHQLEDPS | VFPAVIVEQV | PYPDLLHLYS | 
    100:
    GLELDDVHNG | IITDGTLCMT | QDQILEGSFL | LTDDNEATSH | TMSTAEVLLN | 
    150:
    MESPSDILDE | KQIFSTSEML | PDSDPAPAVT | LPNYLFPASE | PDALNRAGDT | 
    200:
    SDQEGHSLEE | KASREESAKK | TGKSKKRIRK | TKGNRSTSPV | TDPSIPIRKK | 
    250:
    SKDGKGSTIY | LWEFLLALLQ | DRNTCPKYIK | WTQREKGIFK | LVDSKAVSKL | 
    300:
    WGKQKNKPDM | NYETMGRALR | YYYQRGILAK | VEGQRLVYQF | KEMPKDLVVI | 
    350:
    EDEDESSEAT | AAPPQASTAS | VASASTTRRT | SSRVSSRSAP | QGKGSSSWEK | 
    400:
    PKIQHVGLQP | SASLELGPSL | DEEIPTTSTM | LVSPAEGQVK | LTKAVSASSV | 
    450:
    PSNIHLGVAP | VGSGSALTLQ | TIPLTTVLTN | GPPASTTAPT | QLVLQSVPAA | 
    500:
    STFKDTFTLQ | ASFPLNASFQ | DSQVAAPGAP | LILSGLPQLL | AGANRPTNPA | 
    550:
    PPTVTGAGPA | GPSSQPPGTV | IAAFIRTSGT | TAAPRVKEGP | LRSSSYVQGM | 
    600:
    VTGAPMEGLL | VPEETLRELL | RDQAHLQPLP | TQVVSRGSHN | PSLLGNQTLS | 
    650:
    PPSRPTVGLT | PVAELELSSG | SGSLLMAEPS | VTTSGSLLTR | SPTPAPFSPF | 
    663:
    NPTSLIKMEP | HDI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human ETS-related transcription factor Elf-4
    ELISA Kit for Human ETS-related transcription factor Elf-4
    CLIA Kit for Human ETS-related transcription factor Elf-4
    CLIA Kit for Human ETS-related transcription factor Elf-4
    Polyclonal Antibody for Human ETS-related transcription factor Elf-4
    Polyclonal Antibody for Human ETS-related transcription factor Elf-4
    Monoclonal Antibody for Human ETS-related transcription factor Elf-4
    Monoclonal Antibody for Human ETS-related transcription factor Elf-4
    Protein for Human ETS-related transcription factor Elf-4
    Protein for Human ETS-related transcription factor Elf-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties."
      Miyazaki Y. , Sun X. , Uchida H. , Zhang J. , Nimer S.
      Oncogene13:1721-1729(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Promyelocytic leukemia.
    2. 2.
      "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1."
      Aryee D.N.T. , Petermann R. , Kos K. , Henn T. , Haas O.A. , Kovar H.
      Gene210:71-78(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Ewing sarcoma.
    3. 3.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    6. 6.
      "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias."
      Mao S. , Frank R.C. , Zhang J. , Miyazaki Y. , Nimer S.D.
      Mol. Cell. Biol.19:3635-3644(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RUNX1
    7. 7.
      "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells."
      Hedvat C.V. , Yao J. , Sokolic R.A. , Nimer S.D.
      J. Biol. Chem.279:6395-6400(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein."
      Suico M.A. , Yoshida H. , Seki Y. , Uchikawa T. , Lu Z. , Shuto T. , Matsuzaki K. , Nakao M. , Li J.-D. , Kai H.
      J. Biol. Chem.279:19091-19098(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PML
    9. 9.
      "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)."
      Moore S.D. , Offor O. , Ferry J.A. , Amrein P.C. , Morton C.C. , Dal Cin P.
      Leuk. Res.30:1037-1042(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH ERG
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation."
      Sashida G. , Liu Y. , Elf S. , Miyata Y. , Ohyashiki K. , Izumi M. , Menendez S. , Nimer S.D.
      Mol. Cell. Biol.29:3687-3699(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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