Gene name:
ELF4 (ELFR;MEF) ;
Protein name:
ETS-related transcription factor Elf-4 ;
Alternative:
Myeloid Elf-1-like factor ;E74-like factor 4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ.
Function:
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway.
Subcellular Location:
Nucleus
PML body
Accumulation into PML nuclear bodies is mediated by PML.
Protein Attributes:
50:
MAITLQPSDL | IFEFASNGMD | DDIHQLEDPS | VFPAVIVEQV | PYPDLLHLYS |
100:
GLELDDVHNG | IITDGTLCMT | QDQILEGSFL | LTDDNEATSH | TMSTAEVLLN |
150:
MESPSDILDE | KQIFSTSEML | PDSDPAPAVT | LPNYLFPASE | PDALNRAGDT |
200:
SDQEGHSLEE | KASREESAKK | TGKSKKRIRK | TKGNRSTSPV | TDPSIPIRKK |
250:
SKDGKGSTIY | LWEFLLALLQ | DRNTCPKYIK | WTQREKGIFK | LVDSKAVSKL |
300:
WGKQKNKPDM | NYETMGRALR | YYYQRGILAK | VEGQRLVYQF | KEMPKDLVVI |
350:
EDEDESSEAT | AAPPQASTAS | VASASTTRRT | SSRVSSRSAP | QGKGSSSWEK |
400:
PKIQHVGLQP | SASLELGPSL | DEEIPTTSTM | LVSPAEGQVK | LTKAVSASSV |
450:
PSNIHLGVAP | VGSGSALTLQ | TIPLTTVLTN | GPPASTTAPT | QLVLQSVPAA |
500:
STFKDTFTLQ | ASFPLNASFQ | DSQVAAPGAP | LILSGLPQLL | AGANRPTNPA |
550:
PPTVTGAGPA | GPSSQPPGTV | IAAFIRTSGT | TAAPRVKEGP | LRSSSYVQGM |
600:
VTGAPMEGLL | VPEETLRELL | RDQAHLQPLP | TQVVSRGSHN | PSLLGNQTLS |
650:
PPSRPTVGLT | PVAELELSSG | SGSLLMAEPS | VTTSGSLLTR | SPTPAPFSPF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human ETS-related transcription factor Elf-4
ELISA Kit for Human ETS-related transcription factor Elf-4
CLIA Kit for Human ETS-related transcription factor Elf-4
CLIA Kit for Human ETS-related transcription factor Elf-4
Polyclonal Antibody for Human ETS-related transcription factor Elf-4
Polyclonal Antibody for Human ETS-related transcription factor Elf-4
Monoclonal Antibody for Human ETS-related transcription factor Elf-4
Monoclonal Antibody for Human ETS-related transcription factor Elf-4
Protein for Human ETS-related transcription factor Elf-4
Protein for Human ETS-related transcription factor Elf-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151 AND SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .