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Index > Protein center > Uba3(Gene name) > Mouse
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  • Uba3 (Gene name),
  • NEDD8-activating enzyme E1 catalytic subunit (Protein name ),  UBA3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Uba3(Ube1c);
    Protein name:
    NEDD8-activating enzyme E1 catalytic subunit;
    Alternative:
    Ubiquitin-activating enzyme E1C;NEDD8-activating enzyme E1C;Ubiquitin-like modifier-activating enzyme 3(Ubiquitin-activating enzyme 3);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand.
    Function:
    Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    462
    Sequence:
    50:
    MADGEEPEKK | RRRIEELLAE | KMAVDGGCGD | TGDWEGRWNH | VKKFLERSGP | 
    100:
    FTHPDFEPST | ESLQFLLDTC | KVLVIGAGGL | GCELLKNLAL | SGFRQIHVID | 
    150:
    MDTIDVSNLN | RQFLFRPKDV | GRPKAEVAAE | FLNDRVPNCN | VVPHFNKIQD | 
    200:
    FNDTFYRQFH | IIVCGLDSII | ARRWINGMLI | SLLNYEDGVL | DPSSIVPLID | 
    250:
    GGTEGFKGNA | RVILPGMTAC | IECTLELYPP | QVNFPMCTIA | SMPRLPEHCI | 
    300:
    EYVRMLQWPK | EQPFGDGVPL | DGDDPEHIQW | IFQKSIERAS | QYNIRGVTYR | 
    350:
    LTQGVVKRII | PAVASTNAVI | AAVCATEVFK | IATSAYIPLN | NYLVFNDVDG | 
    400:
    LYTYTFEAER | KENCPACSQL | PQNIQFSPSA | KLQEVLDYLT | NSASLQMKSP | 
    450:
    AITATLEGKN | RTLYLQSVTS | IEERTRPNLS | KTLKELGLVD | GQELAVADVT | 
    462:
    TPQTVLFKLH | FT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    E1027h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    E1027m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    E1027r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Monoclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Monoclonal Antibody for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Protein for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Protein for Mouse NEDD8-activating enzyme E1 catalytic subunit
    Protein for Mouse NEDD8-activating enzyme E1 catalytic subunit

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryonic head.
      tissue: Kidney.
      tissue: Placenta.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-462 (ISOFORM 1)
    4. 4.
      "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway."
      Gong L. , Yeh E.T.H.
      J. Biol. Chem.274:12036-12042(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-462 (ISOFORM 1)
      tissue: Liver.
    5. 5.
      "The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice."
      Tateishi K. , Omata M. , Tanaka K. , Chiba T.
      J. Cell Biol.155:571-580(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-462 (ISOFORM 1);FUNCTION
      strain: C57BL/6.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBATA
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