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Index > Protein center > ENOX2(Gene name) > Human
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  • ENOX2 (Gene name),
  • Ecto-NOX disulfide-thiol exchanger 2 (Protein name ),  ENOX2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ENOX2(COVA1);
    Protein name:
    Ecto-NOX disulfide-thiol exchanger 2;
    Alternative:
    Cytosolic ovarian carcinoma antigen 1;APK1 antigen;Tumor-associated hydroquinone oxidase(tNOX);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
    Subcellular Location:
    Cell membrane Secreted extracellular space Extracellular and plasma membrane-associated.
    Protein Attributes:
    Sequence length:
    610
    Sequence:
    50:
    MQRDFRWLWV | YEIGYAADNS | RTLNVDSTAM | TLPMSDPTAW | ATAMNNLGMA | 
    100:
    PLGIAGQPIL | PDFDPALGMM | TGIPPITPMM | PGLGIVPPPI | PPDMPVVKEI | 
    150:
    IHCKSCTLFP | PNPNLPPPAT | RERPPGCKTV | FVGGLPENGT | EQIIVEVFEQ | 
    200:
    CGEIIAIRKS | KKNFCHIRFA | EEYMVDKALY | LSGYRIRLGS | STDKKDTGRL | 
    250:
    HVDFAQARDD | LYEWECKQRM | LAREERHRRR | MEEERLRPPS | PPPVVHYSDH | 
    300:
    ECSIVAEKLK | DDSKFSEAVQ | TLLTWIERGE | VNRRSANNFY | SMIQSANSHV | 
    350:
    RRLVNEKAAH | EKDMEEAKEK | FKQALSGILI | QFEQIVAVYH | SASKQKAWDH | 
    400:
    FTKAQRKNIS | VWCKQAEEIR | NIHNDELMGI | RREEEMEMSD | DEIEEMTETK | 
    450:
    ETEESALVSQ | AEALKEENDS | LRWQLDAYRN | EVELLKQEQG | KVHREDDPNK | 
    500:
    EQQLKLLQQA | LQGMQQHLLK | VQEEYKKKEA | ELEKLKDDKL | QVEKMLENLK | 
    550:
    EKESCASRLC | ASNQDSEYPL | EKTMNSSPIK | SEREALLVGI | ISTFLHVHPF | 
    600:
    GASIEYICSY | LHRLDNKICT | SDVECLMGRL | QHTFKQEMTG | VGASLEKRWK | 
    610:
    FCGFEGLKLT | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    E15186h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    E15186m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    U15186m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    U15186h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    P15186Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ecto-NOX disulfide-thiol exchanger 2
    Cat.:
    P15186Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ecto-NOX disulfide-thiol exchanger 2
    Monoclonal Antibody for Human Ecto-NOX disulfide-thiol exchanger 2
    Protein for Human Ecto-NOX disulfide-thiol exchanger 2
    Protein for Human Ecto-NOX disulfide-thiol exchanger 2

    R&D Technical Data

            12% SDS-PAGE Analysis

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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface."
      Chueh P.-J. , Kim C. , Cho N. , Morre D.M. , Morre D.J.
      Biochemistry41:3732-3741(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ENZYME REGULATION;MUTAGENESIS OF MET-396; CYS-505; CYS-510; HIS-546; CYS-558; HIS-562; CYS-569; CYS-575; GLY-592 AND CYS-602;COFACTOR
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    3. 3.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    6. 6.
      Rhodes S. , Huckle E.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-405
    7. 7.
      "Isolation and characterization of a tumor-associated NADH oxidase (tNOX) from the HeLa cell surface."
      Yantiri F. , Morre D.J.
      Arch. Biochem. Biophys.391:149-159(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 86-90; 249-266 AND 318-333
      tissue: Cervix carcinoma.
    8. 8.
      "Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line."
      Chang K. , Pastan I.
      Int. J. Cancer57:90-97(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 275-610;SUBCELLULAR LOCATION;GLYCOSYLATION
      tissue: Ovarian carcinoma.
    9. 9.
      "Inhibition of plasma membrane NADH oxidase activity and growth of HeLa cells by natural and synthetic retinoids."
      Dai S. , Morre D.J. , Geilen C.C. , Almond-Roesler B. , Orfanos C.E. , Morre D.M.
      Mol. Cell. Biochem.166:101-109(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    10. 10.
      "The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity."
      Morre D.J. , Chueh P.-J. , Lawler J. , Morre D.M.
      J. Bioenerg. Biomembr.30:477-487(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION
    11. 11.
      "The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity."
      Kishi T. , Morre D.M. , Morre D.J.
      Biochim. Biophys. Acta1412:66-77(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROQUINONE OXIDASE ACTIVITY
    12. 12.
      "Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion."
      Kelker M. , Kim C. , Chueh P.-J. , Guimont R. , Morre D.M. , Morre D.J.
      Biochemistry40:7351-7354(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRION-LIKE PROPERTIES
    13. 13.
      "Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs."
      Morre D.J. , Sedlak D. , Tang X. , Chueh P.-J. , Geng T. , Morre D.M.
      Arch. Biochem. Biophys.392:251-256(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "Monoclonal antibody to a cancer-specific and drug-responsive hydroquinone (NADH) oxidase from the sera of cancer patients."
      Cho N. , Chueh P.-J. , Kim C. , Caldwell S. , Morre D.M. , Morre D.J.
      Cancer Immunol. Immunother.51:121-129(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN BIOLOGICAL CLOCK CONTROL
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-202
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