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Index > Protein center > ENSA(Gene name) > Pig
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  • ENSA (Gene name),
  • Alpha-endosulfine (Protein name ),  ENSA_PIG from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ENSA;
    Protein name:
    Alpha-endosulfine;
    Alternative:
    ARPP-19e;
    Organism:
    Pig (Sus scrofa). 
    General Annotation
    Sub Unit:
    Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.
    Function:
    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    121
    Sequence:
    50:
    MSQKQEEENP | AEETGEEKQD | TQEKEGILPE | KAEEAKLKAK | YPSLGQKPGG | 
    100:
    SDFLMKRLQK | GQKYFDSGDY | NMAKAKMKNK | QLPSAGPDKN | LVTGDHIPTP | 
    121:
    QDLPQRKSSL | VTSKLAGGQV | E
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Pig Alpha-endosulfine
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    E15255h
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    ELISA Kit for Pig Alpha-endosulfine
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    E15255p
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    96T
    ELISA Kit for Pig Alpha-endosulfine
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    E15255r
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    96T
    ELISA Kit for Pig Alpha-endosulfine
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    E15255m
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    ELISA Kit for Pig Alpha-endosulfine
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    E15255c
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    ELISA Kit for Pig Alpha-endosulfine
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    E15255b
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    Packing:
    96T
    CLIA Kit for Pig Alpha-endosulfine
    Cat.:
    U15255b
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    MSDS:
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    96T
    CLIA Kit for Pig Alpha-endosulfine
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    U15255p
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    MSDS:
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    96T
    CLIA Kit for Pig Alpha-endosulfine
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    U15255c
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    96T
    CLIA Kit for Pig Alpha-endosulfine
    Cat.:
    U15255r
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    MSDS:
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    96T
    CLIA Kit for Pig Alpha-endosulfine
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    U15255h
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    96T
    CLIA Kit for Pig Alpha-endosulfine
    Cat.:
    U15255m
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    Packing:
    96T
    Polyclonal Antibody for Pig Alpha-endosulfine
    Cat.:
    P15255Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig Alpha-endosulfine
    Polyclonal Antibody for Pig Alpha-endosulfine
    Polyclonal Antibody for Pig Alpha-endosulfine
    Cat.:
    P15255Rb-h
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    Packing:
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    Polyclonal Antibody for Pig Alpha-endosulfine
    Polyclonal Antibody for Pig Alpha-endosulfine
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    P15255Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Pig Alpha-endosulfine
    Monoclonal Antibody for Pig Alpha-endosulfine
    Monoclonal Antibody for Pig Alpha-endosulfine
    Monoclonal Antibody for Pig Alpha-endosulfine
    Monoclonal Antibody for Pig Alpha-endosulfine
    Monoclonal Antibody for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine
    Protein for Pig Alpha-endosulfine

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    References
    1. 1.
      "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties."
      Heron L. , Virsolvy A. , Peyrollier K. , Gribble F.M. , Le Cam A. , Ashcroft F.M. , Bataille D.
      Proc. Natl. Acad. Sci. U.S.A.95:8387-8391(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Endosulfine, endogenous ligand for the sulphonylurea receptor: isolation from porcine brain and partial structural determination of the alpha form."
      Virsolvy-Vergine A. , Salazar G. , Sillard R. , Denoroy L. , Mutt V. , Bataille D.
      Diabetologia39:135-141(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-36; 39-57; 59-74 AND 81-106;MASS SPECTROMETRY;CHARACTERIZATION
      tissue: Brain.
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