Protein name:
Alpha-endosulfine ;
Alternative:
ARPP-19e ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts (when phosphorylated at Ser-67) with PPP2R2D. Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.
Function:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSQKQEEENP | AEETGEEKQD | TQEKEGILPE | KAEEAKLKAK | YPSLGQKPGG |
100:
SDFLMKRLQK | GQKYFDSGDY | NMAKAKMKNK | QLPSAGADKN | LVTGDHIPTP |
121:
QDLPQRKSSL | VTSKLAGGQV | E
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Rat
Mouse
Chicken
Bovine
ELISA Kit for Rat Alpha-endosulfine
ELISA Kit for Rat Alpha-endosulfine
ELISA Kit for Rat Alpha-endosulfine
ELISA Kit for Rat Alpha-endosulfine
ELISA Kit for Rat Alpha-endosulfine
ELISA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
CLIA Kit for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Polyclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Monoclonal Antibody for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
Protein for Rat Alpha-endosulfine
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Pituitary .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-109