EPAS1 ELISA Kit for Human(Homo sapiens) | EIAab.comEPAS1 ELISA Kit for Human(Homo sapiens)

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EPAS1 (Gene name),

Endothelial PAS domain-containing protein 1 (Protein name ), EPAS1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

EPAS1(BHLHE73;HIF2A;MOP2;PASD2);

Protein name:

Endothelial PAS domain-containing protein 1(EPAS-1);

Alternative:

Class E basic helix-loop-helix protein 73(bHLHe73);Basic-helix-loop-helix-PAS protein MOP2;Hypoxia-inducible factor 2-alpha(HIF-2-alpha;HIF2-alpha);HIF-1-alpha-like factor(HLF);PAS domain-containing protein 2;Member of PAS protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP.

Function:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

870

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

870:

LGSSTLLQGG | DLLRALDQAT |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.468410

Pfam:

PF11413

SMR:

Q99814

KEGG:

hsa:2034

MIM:

603349

String:

Q99814

STRING:

9606.ENSP00000263734

Uniprot:

Q99814

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ELISA Kit for Human EPAS-1

Cat.:

E2004h

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96T

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ELISA Kit for Human EPAS-1

Cat.:

E2004m

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96T

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ELISA Kit for Human EPAS-1

Cat.:

E2004r

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Packing:

96T

CLIA Kit for Human EPAS-1

Cat.:

U2004m

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Packing:

96T

CLIA Kit for Human EPAS-1

Cat.:

U2004h

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MSDS:

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Packing:

96T

CLIA Kit for Human EPAS-1

Cat.:

U2004r

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Packing:

96T

Polyclonal Antibody for Human EPAS-1

Cat.:

P2004Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human EPAS-1

Cat.:

P2004Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human EPAS-1

Cat.:

P2004Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human EPAS-1

Protein for Human EPAS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells."
Tian H. , McKnight S.L. , Russell D.W.
Genes Dev.11:72-82(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
Hogenesch J.B. , Chan W.K. , Jackiw V.H. , Brown R.C. , Gu Y.-Z. , Pray-Grant M. , Perdew G.H. , Bradfield C.A.
J. Biol. Chem.272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hepatoma.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
4.

"Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300."
Ema M. , Hirota K. , Mimura J. , Abe H. , Yodoi J. , Sogawa K. , Poellinger L. , Fujii-Kuriyama Y.
EMBO J.18:1905-1914(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSACTIVATION DOMAINS NTAD AND CTAD;INTERACTION WITH APEX;MUTAGENESIS OF CYS-844
5.

"Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline."
Furlow P.W. , Percy M.J. , Sutherland S. , Bierl C. , McMullin M.F. , Master S.R. , Lappin T.R. , Lee F.S.
J. Biol. Chem.284:9050-9058(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN1 AND VHL;VARIANT ECYT4 LEU-534;CHARACTERIZATION OF VARIANTS ECYT4 LEU-534; VAL-535 AND ARG-537
6.

"Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis."
Percy M.J. , Beer P.A. , Campbell G. , Dekker A.W. , Green A.R. , Oscier D. , Rainey M.G. , van Wijk R. , Wood M. , Lappin T.R. , McMullin M.F. , Lee F.S.
Blood111:5400-5402(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT4 VAL-535 AND ARG-537
7.

"A gain-of-function mutation in the HIF2A gene in familial erythrocytosis."
Percy M.J. , Furlow P.W. , Lucas G.S. , Li X. , Lappin T.R. , McMullin M.F. , Lee F.S.
N. Engl. J. Med.358:162-168(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECYT4 TRP-537;IDENTIFICATION BY MASS SPECTROMETRY;CHARACTERIZATION OF VARIANT ECYT4 TRP-537
8.

"Two new mutations in the HIF2A gene associated with erythrocytosis."
Percy M.J. , Chung Y.J. , Harrison C. , Mercieca J. , Hoffbrand A.V. , Dinardo C.L. , Santos P.C. , Fonseca G.H. , Gualandro S.F. , Pereira A.C. , Lappin T.R. , McMullin M.F. , Lee F.S.
Am. J. Hematol.87:439-442(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ECYT4 THR-535 AND LEU-540;CHARACTERIZATION OF VARIANT ECYT4 LEU-540

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