Epas1 ELISA Kit for Mouse(Mus musculus) | EIAab.comEpas1 ELISA Kit for Mouse(Mus musculus)

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Epas1 (Gene name),

Endothelial PAS domain-containing protein 1 (Protein name ), EPAS1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Epas1(Hif2a);

Protein name:

Endothelial PAS domain-containing protein 1(EPAS-1);

Alternative:

HIF-related factor(HRF);HIF-1-alpha-like factor(HLF;mHLF);Hypoxia-inducible factor 2-alpha(HIF-2-alpha;HIF2-alpha);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBPB.

Function:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

874

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

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550:

600:

650:

700:

750:

800:

850:

874:

NVPVPGSSTL | LQGRDLLRAL | DQAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P97481

STRING:

10090.ENSMUSP00000107892

UniGene:

Mm.1415

Pfam:

PF11413

KEGG:

mmu:13819

String:

P97481

Uniprot:

P97481

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ELISA Kit for Mouse EPAS-1

Cat.:

E2004h

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96T

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ELISA Kit for Mouse EPAS-1

Cat.:

E2004m

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96T

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ELISA Kit for Mouse EPAS-1

Cat.:

E2004r

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96T

CLIA Kit for Mouse EPAS-1

Cat.:

U2004m

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96T

CLIA Kit for Mouse EPAS-1

Cat.:

U2004h

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96T

CLIA Kit for Mouse EPAS-1

Cat.:

U2004r

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96T

Polyclonal Antibody for Mouse EPAS-1

Cat.:

P2004Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse EPAS-1

Cat.:

P2004Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse EPAS-1

Cat.:

P2004Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse EPAS-1

Protein for Mouse EPAS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells."
Tian H. , McKnight S.L. , Russell D.W.
Genes Dev.11:72-82(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development."
Ema M. , Taya S. , Yokotani N. , Sogawa K. , Matsuda Y. , Fujii-Kuriyama Y.
Proc. Natl. Acad. Sci. U.S.A.94:4273-4278(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Hypothalamus.
tissue: Skeletal muscle.
3.

"HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels."
Flamme I. , Froehlich T. , von Reutern M. , Kappel A. , Damert A. , Risau W.
Mech. Dev.63:51-60(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain capillary.
4.

"FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor."
Lando D. , Peet D.J. , Gorman J.J. , Whelan D.A. , Whitelaw M.L. , Bruick R.K.
Genes Dev.16:1466-1471(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 846-864;MUTAGENESIS OF PRO-530 AND ASN-851
5.

"The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine."
Gradin K. , Takasaki C. , Fujii-Kuriyama Y. , Sogawa K.
J. Biol. Chem.277:23508-23514(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CREBBP;PHOSPHORYLATION AT THR-844;MUTAGENESIS OF THR-844
6.

"Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch."
Lando D. , Peet D.J. , Whelan D.A. , Gorman J.J. , Whitelaw M.L.
Science295:858-861(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION AT ASN-851

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