Homodimer. Forms a signaling complex with LCK; PTK2B AND PI3-KINASE upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2.
Function:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity EFNA1/ephrin-A1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-160 AND VAL-900
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ALA-160 AND VAL-900
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);ALTERNATIVE SPLICING
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS ALA-160 AND VAL-900
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS ALA-160 AND VAL-900
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ALA-160 AND VAL-900
"An EGFR/eph chimeric receptor possesses ligand stimulated tyrosine kinase activity and promotes cell growth." Tuzi N.L.
Submitted (1994-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-976 (ISOFORM 1);VARIANT VAL-900
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Cited for: FUNCTION IN MIGRATION OF T-LYMPHOCYTES;INTERACTION WITH LCK; PTK2B/PYK2 AND PI3-KINASE
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Cited for: FUNCTION IN CELL SPREADING;FUNCTION IN CELL MIGRATION;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION;INTERACTION WITH PTK2/FAK1 AND ILK
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Cited for: FUNCTION IN ANGIOGENESIS;FUNCTION IN CELL PROLIFERATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-906 AND SER-910;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 911-974
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Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-160; CYS-351; GLN-492; GLN-575; THR-585; LEU-697; LYS-703; ARG-807 AND VAL-900
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Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-900;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
