Epha5 ELISA Kit for Mouse(Mus musculus) | EIAab.comEpha5 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Epha5 (Gene name),

Ephrin type-A receptor 5 (Protein name ), EPHA5_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Epha5(Bsk;Ehk1);

Protein name:

Ephrin type-A receptor 5;

Alternative:

CEK-7;Brain-specific kinase;EPH homology kinase 1(EHK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.

Function:

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cell projection axon Cell projection dendrite

Protein Attributes:

Sequence length:

876

Sequence:

50:

MRGSGPRGAG | HRRTQGRGGG | DDTPRVPASL | AGCYSAPLKG | PLWTCLLLCA |

100:

ALRTLLASPS | NEVNLLDSRT | VMGDLGWIAF | PKNGWEEIGE | VDENYAPIHT |

150:

YQVCKVMEQN | QNNWLLTSWI | SNEGASRIFI | ELKFTLRDCN | SLPGGLGTCK |

200:

ETFNMYYFES | DDENGRSIKE | NQYIKIDTIA | ADESFTELDL | GDRVMKLNTE |

250:

VRDVGPLSKK | GFYLAFQDVG | ACIALVSVRV | YYKKCPSVVR | HLAIFPDTIT |

300:

GADSSQLLEV | SGSCVNHSVT | DDPPKMHCSA | EGEWLVPIGK | CMCKAGYEEK |

350:

NGTCQAPSPV | TNVKKGKIAK | NSISLSWQEP | DRPNGIILEY | EIKYFEKDQE |

400:

TSYTIIKSKE | TSITAEGLKP | ASVYVFQIRA | RTAAGYGVFS | RRFEFETTPV |

450:

SVAASNDQSQ | IPIIAVSVTV | GVILLAVMIG | FLLSGSCCDC | GCGRASSLCA |

500:

VAHPSLIWRC | GYSKAKQDPE | EEKMHFHNGH | IKLPGVRTYI | DPHTYEDPNQ |

550:

AVHEFAKEIE | ASCITIERVI | GAGEFGEVCS | GRLKLPGKRE | LPVAIKTLKV |

600:

GYTEKQRRDF | LGEASIMGQF | DHPNIIHLEG | VVTKSKPVMI | VTEYMENGSL |

650:

DTFLKKNDGQ | FTVIQLVGML | RGIAAGMKYL | SDMGYVHRDL | AARNILINSN |

700:

LVCKVSDFGL | SRVLEDDPEA | AYTTRGGKIP | IRWTAPEAIA | FRKFTSSSDV |

750:

WSYGIVMWEV | VSYGERPYWE | MTNQDVIKAV | EEGYRLPSPM | DCPAALYQLM |

800:

LDCWQKDRNS | RPKFDEIVNM | LDKLIRNPSS | LKTLVNASSR | VSTLLAEHGS |

850:

LGSGAYRSVG | EWLEAIKMGR | YTEIFMENGY | SSMDAVAQVT | LEDLRRLGVT |

876:

LVGHQKKIMS | SLQEMKVQMV | NGMVPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Pfam:

SMR:

KEGG:

String:

Pfam:

Uniprot:

FOR

ELISA Kit for Mouse Ephrin type-A receptor 5

ELISA Kit for Mouse Ephrin type-A receptor 5

ELISA Kit for Mouse Ephrin type-A receptor 5

ELISA Kit for Mouse Ephrin type-A receptor 5

CLIA Kit for Mouse Ephrin type-A receptor 5

CLIA Kit for Mouse Ephrin type-A receptor 5

CLIA Kit for Mouse Ephrin type-A receptor 5

CLIA Kit for Mouse Ephrin type-A receptor 5

Polyclonal Antibody for Mouse Ephrin type-A receptor 5

Polyclonal Antibody for Mouse Ephrin type-A receptor 5

Polyclonal Antibody for Mouse Ephrin type-A receptor 5

Polyclonal Antibody for Mouse Ephrin type-A receptor 5

Monoclonal Antibody for Mouse Ephrin type-A receptor 5

Monoclonal Antibody for Mouse Ephrin type-A receptor 5

Monoclonal Antibody for Mouse Ephrin type-A receptor 5

Monoclonal Antibody for Mouse Ephrin type-A receptor 5

Protein for Mouse Ephrin type-A receptor 5

Protein for Mouse Ephrin type-A receptor 5

Protein for Mouse Ephrin type-A receptor 5

Protein for Mouse Ephrin type-A receptor 5

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system."
Zhou R. , Copeland T.D. , Kromer L.F. , Schulz N.T.
J. Neurosci. Res.37:129-143(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: BALB/c.
tissue: Brain.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Mistargeting hippocampal axons by expression of a truncated Eph receptor."
Yue Y. , Chen Z.Y. , Gale N.W. , Blair-Flynn J. , Hu T.J. , Yue X. , Cooper M. , Crockett D.P. , Yancopoulos G.D. , Tessarollo L. , Zhou R.
Proc. Natl. Acad. Sci. U.S.A.99:10777-10782(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON GUIDANCE;PHOSPHORYLATION
4.

"EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets."
Konstantinova I. , Nikolova G. , Ohara-Imaizumi M. , Meda P. , Kucera T. , Zarbalis K. , Wurst W. , Nagamatsu S. , Lammert E.
Cell129:359-370(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INSULIN SECRETION;TISSUE SPECIFICITY;PHOSPHORYLATION;DEPHOSPHORYLATION

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