Epha8 ELISA Kit for Mouse(Mus musculus) | EIAab.comEpha8 ELISA Kit for Mouse(Mus musculus)

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Epha8 (Gene name),

Ephrin type-A receptor 8 (Protein name ), EPHA8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Epha8(Eek);

Protein name:

Ephrin type-A receptor 8;

Alternative:

Tyrosine-protein kinase receptor EEK;EPH- and ELK-related kinase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). May also form heterodimers with other ephrin receptors. Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.

Function:

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cell projection Early endosome membrane Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.

Protein Attributes:

Sequence length:

1004

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1004:

RRHL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.1390

KEGG:

mmu:13842

String:

O09127

SMR:

O09127

Pfam:

PF01404

STRING:

10090.ENSMUSP00000030420

Pfam:

PF14575

Uniprot:

O09127

FOR

ELISA Kit for Mouse Ephrin type-A receptor 8

CLIA Kit for Mouse Ephrin type-A receptor 8

Polyclonal Antibody for Mouse Ephrin type-A receptor 8

Monoclonal Antibody for Mouse Ephrin type-A receptor 8

Protein for Mouse Ephrin type-A receptor 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands."
Park S. , Sanchez M.P.
Oncogene14:533-542(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH EFNA2; EFNA3 AND EFNA5;PHOSPHORYLATION;TOPOLOGY;SUBCELLULAR LOCATION
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors."
Park S. , Frisen J. , Barbacid M.
EMBO J.16:3106-3114(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON GUIDANCE;DEVELOPMENTAL STAGE
4.

"Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity."
Choi S. , Park S.
Oncogene18:5413-5422(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL ADHESION;INTERACTION WITH FYN;PHOSPHORYLATION AT TYR-615 AND TYR-838;MUTAGENESIS OF TYR-615 AND TYR-838
5.

"The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner."
Gu C. , Park S.
Mol. Cell. Biol.21:4579-4597(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN-MEDIATED CELL ADHESION;MUTAGENESIS OF TYR-615; LYS-666 AND TYR-792;INTERACTION WITH PIK3CG
6.

"The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration."
Gu C. , Park S.
FEBS Lett.540:65-70(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION
7.

"The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells."
Gu C. , Shim S. , Shin J. , Kim J. , Park J. , Han K. , Park S.
Oncogene24:4243-4256(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MAP KINASE ACTIVATION AND NEURITE OUTGROWTH;SUBCELLULAR LOCATION
8.

"Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function."
Shin J. , Gu C. , Park E. , Park S.
Mol. Cell. Biol.27:8113-8126(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION AND NEURITE RETRACTION;INTERACTION WITH ANKS1A AND ANKS1B;SUBCELLULAR LOCATION
9.

"The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors."
Kim J. , Lee H. , Kim Y. , Yoo S. , Park E. , Park S.
Mol. Cell. Biol.30:1582-1592(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY CBL;INTERACTION WITH ANKS1A
10.

"EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor."
Yoo S. , Shin J. , Park S.
Mol. Cells29:603-609(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH TIAM1

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