EPN1 ELISA Kit for Human(Homo sapiens) | EIAab.comEPN1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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EPN1 (Gene name),

Epsin-1 (Protein name ), EPN1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

EPN1;

Protein name:

Epsin-1;

Alternative:

EPS-15-interacting protein 1;EH domain-binding mitotic phosphoprotein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1. Binds ubiquitinated proteins (By similarity). Binds REPS2, EPS15, AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1.

Function:

Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

Subcellular Location:

Cytoplasm Cell membrane Peripheral membrane protein Nucleus Membrane clathrin-coated pit Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145.

Protein Attributes:

Sequence length:

576

Sequence:

50:

MSTSSLRRQM | KNIVHNYSEA | EIKVREATSN | DPWGPSSSLM | SEIADLTYNV |

100:

VAFSEIMSMI | WKRLNDHGKN | WRHVYKAMTL | MEYLIKTGSE | RVSQQCKENM |

150:

YAVQTLKDFQ | YVDRDGKDQG | VNVREKAKQL | VALLRDEDRL | REERAHALKT |

200:

KEKLAQTATA | SSAAVGSGPP | PEAEQAWPQS | SGEEELQLQL | ALAMSKEEAD |

250:

QPPSCGPEDD | AQLQLALSLS | REEHDKEERI | RRGDDLRLQM | AIEESKRETG |

300:

GKEESSLMDL | ADVFTAPAPA | PTTDPWGGPA | PMAAAVPTAA | PTSDPWGGPP |

350:

VPPAADPWGG | PAPTPASGDP | WRPAAPAGPS | VDPWGGTPAP | AAGEGPTPDP |

400:

WGSSDGGVPV | SGPSASDPWT | PAPAFSDPWG | GSPAKPSTNG | TTAAGGFDTE |

450:

PDEFSDFDRL | RTALPTSGSS | AGELELLAGE | VPARSPGAFD | MSGVRGSLAE |

500:

AVGSPPPAAT | PTPTPPTRKT | PESFLGPNAA | LVDLDSLVSR | PGPTPPGAKA |

550:

SNPFLPGGGP | ATGPSVTNPF | QPAPPATLTL | NQLRLSPVPP | VPGAPPTYIS |

576:

PLGGGPGLPP | MMPPGPPAPN | TNPFLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

KEGG:

UniGene:

MIM:

String:

SMR:

STRING:

9606.ENSP00000406209

Uniprot:

FOR

ELISA Kit for Human Epsin-1

ELISA Kit for Human Epsin-1

ELISA Kit for Human Epsin-1

CLIA Kit for Human Epsin-1

CLIA Kit for Human Epsin-1

CLIA Kit for Human Epsin-1

Polyclonal Antibody for Human Epsin-1

Polyclonal Antibody for Human Epsin-1

Polyclonal Antibody for Human Epsin-1

Monoclonal Antibody for Human Epsin-1

Monoclonal Antibody for Human Epsin-1

Monoclonal Antibody for Human Epsin-1

Protein for Human Epsin-1

Protein for Human Epsin-1

Protein for Human Epsin-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis."
Morinaka K. , Koyama S. , Nakashima S. , Hinoi T. , Okawa K. , Iwamatsu A. , Kikuchi A.
Oncogene18:5915-5922(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH REPS2
tissue: Brain.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Mammary gland.
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Brain.
5.

"Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation."
Kariya K. , Koyama S. , Nakashima S. , Oshiro T. , Morinaka K. , Kikuchi A.
J. Biol. Chem.275:18399-18406(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-382;MUTAGENESIS OF SER-382;INTERACTION WITH REPS2; EPS15 AND AP-2 ALPHA SUBUNIT
6.

"RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis."
Rosse C. , L'Hoste S. , Offner N. , Picard A. , Camonis J.
J. Biol. Chem.278:30597-30604(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RALBP1
7.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-494;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."
Edeling M.A. , Mishra S.K. , Keyel P.A. , Steinhauser A.L. , Collins B.M. , Roth R. , Heuser J.E. , Owen D.J. , Traub L.M.
Dev. Cell10:329-342(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2B1;MUTAGENESIS OF PHE-404
9.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454 AND THR-460;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-454; THR-460 AND THR-494;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419; SER-420; SER-435; SER-454; THR-460 AND THR-470;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-454; THR-460 AND THR-494;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin."
Koshiba S. , Kigawa T. , Kikuchi A. , Yokoyama S.
J. Struct. Funct. Genomics2:1-8(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-144

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