Protein name:
Epidermal growth factor receptor substrate 15 (Protein Eps15) ;
Alternative:
Protein AF-1p ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2.
Function:
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits.
Subcellular Location:
Isoform 2
Early endosome membrane
Peripheral membrane protein
Cytoplasmic side
Colocalizes with HGS on bilayered clathrin coats on endosomes.
Protein Attributes:
50:
MAAAAQLSLT | QLSSGNPVYE | KYYRQVEAGN | TGRVLALDAA | AFLKKSGLPD |
100:
LILGKIWDLA | DTDGKGVLSK | QEFFVALRLV | ACAQNGLEVS | LSSLSLAVPP |
150:
PRFHDSSSPL | LTSGPSVAEL | PWAVKSEDKA | KYDAIFDSLS | PVDGFLSGDK |
200:
VKPVLLNSKL | PVEILGRVWE | LSDIDHDGKL | DRDEFAVAMF | LVYCALEKEP |
250:
VPMSLPPALV | PPSKRKTWVV | SPAEKAKYDE | IFLKTDKDMD | GYVSGLEVRE |
300:
TFLKTGLPSA | LLAHIWSLCD | TKGCGKLSKD | QFALAFHLIN | QKLIKGIDPP |
350:
HSLTPEMIPP | SDRSSLQKNI | TGSSPVADFS | AIKELDTLNN | EIVDLQREKN |
400:
NVEQDLKEKE | DTVKQRTSEV | QDLQDEVQRE | SINLQKLQAQ | KQQVQELLGE |
450:
LDEQKAQLEE | QLQEVRKKCA | EEAQLISSLK | AEITSQESQI | SSYEEELLKA |
500:
REELSRLQQE | TAQLEESVES | GKAQLEPLQQ | HLQESQQEIS | SMQMRLEMKD |
550:
LETDNNQSNW | SSSPQSVLVN | GATDYCSLST | SSSETANFNE | HAEGQNNLES |
600:
EPTHQESSVR | SSPEIAPSDV | TDESEAVTVA | GNEKVTPRFD | DDKHSKEEDP |
650:
FNVESSSLTD | AVADTNLDFF | QSDPFVGSDP | FKDDPFGKID | PFGGDPFKGS |
700:
DPFASDCFFK | QTSTDPFTTS | STDPFSASSN | SSNTSVETWK | HNDPFAPGGT |
750:
VVAAASDSAT | DPFASVFGNE | SFGDGFADFS | TLSKVNNEDA | FNPTISSSTS |
800:
SVTIAKPMLE | ETASKSEDVP | PALPPKVGTP | TRPCPPPPGK | RPINKLDSSD |
850:
PLKLNDPFQP | FPGNDSPKEK | DPDMFCDPFT | SSTTTNKEAD | PSNFANFSAY |
897:
PSEEDMIEWA | KRESEREEEQ | RLARLNQQEQ | EDLELAIALS | KSEISEA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Protein Eps15
ELISA Kit for Mouse Protein Eps15
CLIA Kit for Mouse Protein Eps15
CLIA Kit for Mouse Protein Eps15
Polyclonal Antibody for Mouse Protein Eps15
Polyclonal Antibody for Mouse Protein Eps15
Monoclonal Antibody for Mouse Protein Eps15
Monoclonal Antibody for Mouse Protein Eps15
Protein for Mouse Protein Eps15
Protein for Mouse Protein Eps15
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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OF1 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SGIP1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-779;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FCHO2
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FCHO2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DAB2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 7-105
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.22 ANGSTROMS) OF 628-632 IN COMPLEX WITH AP2A2