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Index > Protein center > Eps15(Gene name) > Mouse
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  • Eps15 (Gene name),
  • Epidermal growth factor receptor substrate 15 (Protein name ),  EPS15_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Eps15;
    Protein name:
    Epidermal growth factor receptor substrate 15(Protein Eps15);
    Alternative:
    Protein AF-1p;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2.
    Function:
    Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits.
    Subcellular Location:
    Isoform 2 Early endosome membrane Peripheral membrane protein Cytoplasmic side Colocalizes with HGS on bilayered clathrin coats on endosomes.
    Protein Attributes:
    Sequence length:
    897
    Sequence:
    50:
    MAAAAQLSLT | QLSSGNPVYE | KYYRQVEAGN | TGRVLALDAA | AFLKKSGLPD | 
    100:
    LILGKIWDLA | DTDGKGVLSK | QEFFVALRLV | ACAQNGLEVS | LSSLSLAVPP | 
    150:
    PRFHDSSSPL | LTSGPSVAEL | PWAVKSEDKA | KYDAIFDSLS | PVDGFLSGDK | 
    200:
    VKPVLLNSKL | PVEILGRVWE | LSDIDHDGKL | DRDEFAVAMF | LVYCALEKEP | 
    250:
    VPMSLPPALV | PPSKRKTWVV | SPAEKAKYDE | IFLKTDKDMD | GYVSGLEVRE | 
    300:
    TFLKTGLPSA | LLAHIWSLCD | TKGCGKLSKD | QFALAFHLIN | QKLIKGIDPP | 
    350:
    HSLTPEMIPP | SDRSSLQKNI | TGSSPVADFS | AIKELDTLNN | EIVDLQREKN | 
    400:
    NVEQDLKEKE | DTVKQRTSEV | QDLQDEVQRE | SINLQKLQAQ | KQQVQELLGE | 
    450:
    LDEQKAQLEE | QLQEVRKKCA | EEAQLISSLK | AEITSQESQI | SSYEEELLKA | 
    500:
    REELSRLQQE | TAQLEESVES | GKAQLEPLQQ | HLQESQQEIS | SMQMRLEMKD | 
    550:
    LETDNNQSNW | SSSPQSVLVN | GATDYCSLST | SSSETANFNE | HAEGQNNLES | 
    600:
    EPTHQESSVR | SSPEIAPSDV | TDESEAVTVA | GNEKVTPRFD | DDKHSKEEDP | 
    650:
    FNVESSSLTD | AVADTNLDFF | QSDPFVGSDP | FKDDPFGKID | PFGGDPFKGS | 
    700:
    DPFASDCFFK | QTSTDPFTTS | STDPFSASSN | SSNTSVETWK | HNDPFAPGGT | 
    750:
    VVAAASDSAT | DPFASVFGNE | SFGDGFADFS | TLSKVNNEDA | FNPTISSSTS | 
    800:
    SVTIAKPMLE | ETASKSEDVP | PALPPKVGTP | TRPCPPPPGK | RPINKLDSSD | 
    850:
    PLKLNDPFQP | FPGNDSPKEK | DPDMFCDPFT | SSTTTNKEAD | PSNFANFSAY | 
    897:
    PSEEDMIEWA | KRESEREEEQ | RLARLNQQEQ | EDLELAIALS | KSEISEA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein Eps15
    ELISA Kit for Mouse Protein Eps15
    CLIA Kit for Mouse Protein Eps15
    CLIA Kit for Mouse Protein Eps15
    Polyclonal Antibody for Mouse Protein Eps15
    Polyclonal Antibody for Mouse Protein Eps15
    Monoclonal Antibody for Mouse Protein Eps15
    Monoclonal Antibody for Mouse Protein Eps15
    Protein for Mouse Protein Eps15
    Protein for Mouse Protein Eps15

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "eps15, a novel tyrosine kinase substrate, exhibits transforming activity."
      Fazioli F. , Minichiello L. , Matoskova B. , Wong W.T. , di Fiore P.P.
      Mol. Cell. Biol.13:5814-5828(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fibroblast.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Hippocampus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 838-862;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    5. 5.
      "Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis."
      Confalonieri S. , Salcini A.E. , Puri C. , Tacchetti C. , Di Fiore P.P.
      J. Cell Biol.150:905-912(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-850 BY EGFR;MUTAGENESIS OF TYR-850
    6. 6.
      "SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15."
      Uezu A. , Horiuchi A. , Kanda K. , Kikuchi N. , Umeda K. , Tsujita K. , Suetsugu S. , Araki N. , Yamamoto H. , Takenawa T. , Nakanishi H.
      J. Biol. Chem.282:26481-26489(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SGIP1
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-779;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    10. 10.
      "FCHo proteins are nucleators of clathrin-mediated endocytosis."
      Henne W.M. , Boucrot E. , Meinecke M. , Evergren E. , Vallis Y. , Mittal R. , McMahon H.T.
      Science328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO2
    11. 11.
      "Characterization of the EFC/F-BAR domain protein, FCHO2."
      Uezu A. , Umeda K. , Tsujita K. , Suetsugu S. , Takenawa T. , Nakanishi H.
      Genes Cells16:868-878(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO2
    12. 12.
      "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
      Teckchandani A. , Mulkearns E.E. , Randolph T.W. , Toida N. , Cooper J.A.
      Mol. Biol. Cell23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    13. 13.
      "The EH1 domain of Eps15 is structurally classified as a member of the S100 subclass of EF-hand-containing proteins."
      Whitehead B. , Tessari M. , Carotenuto A. , van Bergen en Henegouwen P.M. , Vuister G.W.
      Biochemistry38:11271-11277(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 7-105
    14. 14.
      "Accessory protein recruitment motifs in clathrin-mediated endocytosis."
      Brett T.J. , Traub L.M. , Fremont D.H.
      Structure10:797-809(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.22 ANGSTROMS) OF 628-632 IN COMPLEX WITH AP2A2
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