Eps8 ELISA Kit for Mouse(Mus musculus) | EIAab.comEps8 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Eps8(Gene name) > Mouse

Eps8 (Gene name),

Epidermal growth factor receptor kinase substrate 8 (Protein name ), EPS8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eps8;

Protein name:

Epidermal growth factor receptor kinase substrate 8;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Interacts with BAIAP2 (By similarity). Interacts with SHB and LANCL1.

Function:

Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

821

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

821:

EKISAAASDS | GVESFDEGSS | H

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q08509

UniGene:

Mm.235346

Pfam:

PF08416

SMR:

Q08509

KEGG:

mmu:13860

Uniprot:

Q08509

FOR

ELISA Kit for Mouse Epidermal growth factor receptor kinase substrate 8

CLIA Kit for Mouse Epidermal growth factor receptor kinase substrate 8

Polyclonal Antibody for Mouse Epidermal growth factor receptor kinase substrate 8

Monoclonal Antibody for Mouse Epidermal growth factor receptor kinase substrate 8

Protein for Mouse Epidermal growth factor receptor kinase substrate 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals."
Fazioli F. , Minichiello L. , Matoska V. , Castagnino P. , Miki T. , Wong W.T. , di Fiore P.P.
EMBO J.12:3799-3808(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION IN CELL GROWTH;INTERACTION WITH EGFR;PHOSPHORYLATION
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Bone marrow.
tissue: Lung.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Kidney.
4.

"Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins."
Karlsson T. , Songyang Z. , Landgren E. , Lavergne C. , Di Fiore P.P. , Anafi M. , Pawson T. , Cantley L.C. , Claesson-Welsh L. , Welsh M.
Oncogene10:1475-1483(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
5.

"EPS8 and E3B1 transduce signals from Ras to Rac."
Scita G. , Nordstrom J. , Carbone R. , Tenca P. , Giardina G. , Gutkind S. , Bjarnegard M. , Betsholtz C. , Di Fiore P.P.
Nature401:290-293(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1;DISRUPTION PHENOTYPE
6.

"An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine."
Scita G. , Tenca P. , Areces L.B. , Tocchetti A. , Frittoli E. , Giardina G. , Ponzanelli I. , Sini P. , Innocenti M. , Di Fiore P.P.
J. Cell Biol.154:1031-1044(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SOS1
7.

"Eps8 in the midst of GTPases."
Di Fiore P.P. , Scita G.
Int. J. Biochem. Cell Biol.34:1178-1183(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
8.

"Eps8 controls actin-based motility by capping the barbed ends of actin filaments."
Disanza A. , Carlier M.F. , Stradal T.E. , Didry D. , Frittoli E. , Confalonieri S. , Croce A. , Wehland J. , Di Fiore P.P. , Scita G.
Nat. Cell Biol.6:1180-1188(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ABI1
9.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
11.

"Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
Disanza A. , Mantoani S. , Hertzog M. , Gerboth S. , Frittoli E. , Steffen A. , Berhoerster K. , Kreienkamp H.J. , Milanesi F. , Di Fiore P.P. , Ciliberto A. , Stradal T.E. , Scita G.
Nat. Cell Biol.8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BAIAP2
12.

"Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione."
Zhang W. , Wang L. , Liu Y. , Xu J. , Zhu G. , Cang H. , Li X. , Bartlam M. , Hensley K. , Li G. , Rao Z. , Zhang X.C.
Genes Dev.23:1387-1392(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LANCL1
13.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-658;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)."
Menna E. , Disanza A. , Cagnoli C. , Schenk U. , Gelsomino G. , Frittoli E. , Hertzog M. , Offenhauser N. , Sawallisch C. , Kreienkamp H.J. , Gertler F.B. , Di Fiore P.P. , Scita G. , Matteoli M.
PLoS Biol.7:E1000138-E1000138(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-624 AND THR-628;MUTAGENESIS OF SER-624 AND THR-628
15.

"Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping."
Hertzog M. , Milanesi F. , Hazelwood L. , Disanza A. , Liu H. , Perlade E. , Malabarba M.G. , Pasqualato S. , Maiolica A. , Confalonieri S. , Le Clainche C. , Offenhauser N. , Block J. , Rottner K. , Di Fiore P.P. , Carlier M.F. , Volkmann N. , Hanein D. , more...
PLoS Biol.8:E1000387-E1000387(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF VAL-689; LEU-693; ARG-706 AND PHE-708
16.

"Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8."
Manor U. , Disanza A. , Grati M. , Andrade L. , Lin H. , Di Fiore P.P. , Scita G. , Kachar B.
Curr. Biol.21:167-172(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYO15A AND DFNB31;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
17.

"The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration."
Frittoli E. , Matteoli G. , Palamidessi A. , Mazzini E. , Maddaluno L. , Disanza A. , Yang C. , Svitkina T. , Rescigno M. , Scita G.
Immunity35:388-399(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
18.

"SCF(Fbxw5) mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression."
Werner A. , Disanza A. , Reifenberger N. , Habeck G. , Becker J. , Calabrese M. , Urlaub H. , Lorenz H. , Schulman B. , Scita G. , Melchior F.
Nat. Cell Biol.15:179-188(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;UBIQUITINATION
19.

"The SH3 domain of Eps8 exists as a novel intertwined dimer."
Kishan K.V.R. , Scita G. , Wong W.T. , di Fiore P.P. , Newcomer M.E.
Nat. Struct. Biol.4:739-743(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 532-591;HOMODIMERIZATION

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