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Index > Protein center > Erap1(Gene name) > Mouse
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  • Erap1 (Gene name),
  • Endoplasmic reticulum aminopeptidase 1 (Protein name ),  ERAP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Erap1(Appils;Arts1);
    Protein name:
    Endoplasmic reticulum aminopeptidase 1;
    Alternative:
    Adipocyte-derived leucine aminopeptidase(A-LAP);ARTS-1;Puromycin-insensitive leucyl-specific aminopeptidase(PILS-AP);Aminopeptidase PILS;VEGF-induced aminopeptidase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.
    Function:
    Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    930
    Sequence:
    50:
    MPSLLPLVLT | FLSVSSPSWC | QNSDIESLKA | SNGDSFPWNN | MRLPEYMTPI | 
    100:
    HYDLMIHANL | STLTFWGKTE | VEIIASRPTS | TIIMHSHHLQ | ISKATLRRGA | 
    150:
    GEMLSEEPLK | VLEYPAHEQV | ALLAAQPLLA | GSLYTVIIDY | AANLSESFHG | 
    200:
    FYKSTYRTQE | GEMRILAATQ | FEPTAARMAF | PCFDEPALKA | SFSIKIKRDP | 
    250:
    RHLAISNMPL | VKSVNVAEGL | IEDHFDITVK | MSTYLVAFII | SDFKSVSKMT | 
    300:
    KSGVKVSVYA | VPDKINQADY | ALDAAVTLLE | FYEDYFNIPY | PLPKQDLAAI | 
    350:
    PDFQSGAMEN | WGLTTYRESS | LLYDKEKSSA | SSKLGITMIV | SHELAHQWFG | 
    400:
    NLVTMEWWND | LWLNEGFAKF | MEFVSVTVTH | PELKVEDYFF | GKCFNAMEVD | 
    450:
    ALNSSHPVST | PVENPAQIRE | MFDDVSYEKG | ACILNMLRDY | LSADTFKRGI | 
    500:
    VQYLQKYSYK | NTKNEDLWNS | MMHICPTDGT | QTMDGFCSRS | QHSSSTSHWR | 
    550:
    QEVVDVKTMM | NTWTLQKGFP | LITITVSGRN | VHMKQEHYMK | GSERFPETGY | 
    600:
    LWHVPLTFIT | SKSDSVQRFL | LKTKTDVLIL | PEAVQWIKFN | VGMNGYYIVH | 
    650:
    YADDGWASLS | GLLKEAHTTI | SSNDRASLIN | NAFQLVSIEK | LSIEKALDLT | 
    700:
    LYLKNETEIM | PIFQALNELI | PMYKLMEKRD | MIEVETQFKD | FLLKLLKDLI | 
    750:
    DKQTWTDEGS | VSERMLRSQL | LLLACVRNYQ | PCVQRAERYF | REWKSSNGNM | 
    800:
    SIPIDVTLAV | FAVGAQNTEG | WDFLYSKYQS | SLSSTEKSQI | EFSLCTSKDP | 
    850:
    EKLQWLLDQS | FKGEIIKTQE | FPHILTLIGR | NPVGYPLAWK | FLRENWNKLV | 
    900:
    QKFELGSSSI | AHMVMGTTDQ | FSTRARLEEV | KGFFSSLKEN | GSQLRCVQQT | 
    930:
    IETIEENIRW | MDKNFDKIRL | WLQKEKPELL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    Pfam:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    E12631h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    E12631r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    E12631m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    U12631h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    U12631m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    U12631r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    P12631Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    P12631Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Cat.:
    P12631Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Monoclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Monoclonal Antibody for Mouse Endoplasmic reticulum aminopeptidase 1
    Protein for Mouse Endoplasmic reticulum aminopeptidase 1
    Protein for Mouse Endoplasmic reticulum aminopeptidase 1
    Protein for Mouse Endoplasmic reticulum aminopeptidase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of murine adipocyte-derived leucine aminopeptidase and its expression in adipocyte cell line, 3T3-L1 cells."
      Hattori A. , Kitatani K. , Matsumoto H. , Mizutani S. , Tsujimoto M.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis."
      Miyashita H. , Yamazaki T. , Akada T. , Niizeki O. , Ogawa M. , Nishikawa S. , Sato Y.
      Blood99:3241-3249(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Colon.
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