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Index > Protein center > ERC2(Gene name) > Human
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  • ERC2 (Gene name),
  • ERC protein 2 (Protein name ),  ERC2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ERC2(KIAA0378);
    Protein name:
    ERC protein 2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.
    Function:
    Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
    Subcellular Location:
    Cytoplasm Cell junction synapse Cell junction synapse synaptosome Cytoplasm cytoskeleton In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density.
    Protein Attributes:
    Sequence length:
    957
    Sequence:
    50:
    MYGSARTITN | LEGSPSRSPR | LPRSPRLGHR | RTSSGGGGGT | GKTLSMENIQ | 
    100:
    SLNAAYATSG | PMYLSDHEGV | ASTTYPKGTM | TLGRATNRAV | YGGRVTAMGS | 
    150:
    SPNIASAGLS | HTDVLSYTDQ | HGGLTGSSHH | HHHQVPSMLR | QVRDSTMLDL | 
    200:
    QAQLKELQRE | NDLLRKELDI | KDSKLGSSMN | SIKTFWSPEL | KKERVLRKEE | 
    250:
    AARMSVLKEQ | MRVSHEENQH | LQLTIQALQD | ELRTQRDLNH | LLQQESGNRG | 
    300:
    AEHFTIELTE | ENFRRLQAEH | DRQAKELFLL | RKTLEEMELR | IETQKQTLNA | 
    350:
    RDESIKKLLE | MLQSKGLPSK | SLEDDNERTR | RMAEAESQVS | HLEVILDQKE | 
    400:
    KENIHLREEL | HRRSQLQPEP | AKTKALQTVI | EMKDTKIASL | ERNIRDLEDE | 
    450:
    IQMLKANGVL | NTEDREEEIK | QIEVYKSHSK | FMKTKIDQLK | QELSKKESEL | 
    500:
    LALQTKLETL | SNQNSDCKQH | IEVLKESLTA | KEQRAAILQT | EVDALRLRLE | 
    550:
    EKESFLNKKT | KQLQDLTEEK | GTLAGEIRDM | KDMLEVKERK | INVLQKKIEN | 
    600:
    LQEQLRDKDK | QLTNLKDRVK | SLQTDSSNTD | TALATLEEAL | SEKERIIERL | 
    650:
    KEQRERDDRE | RLEEIESFRK | ENKDLKEKVN | ALQAELTEKE | SSLIDLKEHA | 
    700:
    SSLASAGLKR | DSKLKSLEIA | IEQKKEECSK | LEAQLKKAHN | IEDDSRMNPE | 
    750:
    FADQIKQLDK | EASYYRDECG | KAQAEVDRLL | EILKEVENEK | NDKDKKIAEL | 
    800:
    ESLTLRHMKD | QNKKVANLKH | NQQLEKKKNA | QLLEEVRRRE | DSMADNSQHL | 
    850:
    QIEELMNALE | KTRQELDATK | ARLASTQQSL | AEKEAHLANL | RIERRKQLEE | 
    900:
    ILEMKQEALL | AAISEKDANI | ALLELSASKK | KKTQEEVMAL | KREKDRLVHQ | 
    950:
    LKQQTQNRMK | LMADNYDDDH | HHYHHHHHHH | HHRSPGRSQH | SNHRPSPDQD | 
    957:
    DEEGIWA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human ERC protein 2
    ELISA Kit for Human ERC protein 2
    ELISA Kit for Human ERC protein 2
    CLIA Kit for Human ERC protein 2
    CLIA Kit for Human ERC protein 2
    CLIA Kit for Human ERC protein 2
    Polyclonal Antibody for Human ERC protein 2
    Polyclonal Antibody for Human ERC protein 2
    Polyclonal Antibody for Human ERC protein 2
    Monoclonal Antibody for Human ERC protein 2
    Monoclonal Antibody for Human ERC protein 2
    Monoclonal Antibody for Human ERC protein 2
    Protein for Human ERC protein 2
    Protein for Human ERC protein 2
    Protein for Human ERC protein 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    2. 2.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: PNS.
    4. 4.
      "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins."
      Ko J. , Na M. , Kim S. , Lee J.R. , Kim E.
      J. Biol. Chem.278:42377-42385(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PPFIA1; PPFIA2; PPFIA3 AND PPFIA4
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