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Index > Protein center > ERLEC1(Gene name) > Human
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  • ERLEC1 (Gene name),
  • Endoplasmic reticulum lectin 1 (Protein name ),  ERLEC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ERLEC1(UNQ1878/PRO4321;C2orf30;XTP3TPB);
    Protein name:
    Endoplasmic reticulum lectin 1;
    Alternative:
    XTP3-transactivated gene B protein;ER lectin(Erlectin);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5.
    Function:
    Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
    Subcellular Location:
    Endoplasmic reticulum lumen
    Protein Attributes:
    Sequence length:
    483
    Sequence:
    50:
    MEEGGGGVRS | LVPGGPVLLV | LCGLLEASGG | GRALPQLSDD | IPFRVNWPGT | 
    100:
    EFSLPTTGVL | YKEDNYVIMT | TAHKEKYKCI | LPLVTSGDEE | EEKDYKGPNP | 
    150:
    RELLEPLFKQ | SSCSYRIESY | WTYEVCHGKH | IRQYHEEKET | GQKINIHEYY | 
    200:
    LGNMLAKNLL | FEKEREAEEK | EKSNEIPTKN | IEGQMTPYYP | VGMGNGTPCS | 
    250:
    LKQNRPRSST | VMYICHPESK | HEILSVAEVT | TCEYEVVILT | PLLCSHPKYR | 
    300:
    FRASPVNDIF | CQSLPGSPFK | PLTLRQLEQQ | EEILRVPFRR | NKEEDLQSTK | 
    350:
    EERFPAIHKS | IAIGSQPVLT | VGTTHISKLT | DDQLIKEFLS | GSYCFRGGVG | 
    400:
    WWKYEFCYGK | HVHQYHEDKD | SGKTSVVVGT | WNQEEHIEWA | KKNTARAYHL | 
    450:
    QDDGTQTVRM | VSHFYGNGDI | CDITDKPRQV | TVKLKCKESD | SPHAVTVYML | 
    483:
    EPHSCQYILG | VESPVICKIL | DTADENGLLS | LPN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Endoplasmic reticulum lectin 1
    ELISA Kit for Human Endoplasmic reticulum lectin 1
    CLIA Kit for Human Endoplasmic reticulum lectin 1
    CLIA Kit for Human Endoplasmic reticulum lectin 1
    Polyclonal Antibody for Human Endoplasmic reticulum lectin 1
    Polyclonal Antibody for Human Endoplasmic reticulum lectin 1
    Monoclonal Antibody for Human Endoplasmic reticulum lectin 1
    Monoclonal Antibody for Human Endoplasmic reticulum lectin 1
    Protein for Human Endoplasmic reticulum lectin 1
    Protein for Human Endoplasmic reticulum lectin 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Screening and cloning of the target genes transactivated by XTP3 using a suppression subtractive hybridization technique."
      Wang C. , Cheng J. , Lang Z. , Wu Y. , Yang Y. , Zhang L. , Ji D.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Kidney.
      tissue: Placenta.
    7. 7.
      Mei G. , Yu W. , Gibbs R.A.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-483
      tissue: Brain.
    8. 8.
      "The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition."
      Cruciat C.-M. , Hassler C. , Niehrs C.
      J. Biol. Chem.281:12986-12993(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH KREMEN2;SUBCELLULAR LOCATION;MUTAGENESIS OF GLY-379
    9. 9.
      "Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP."
      Hosokawa N. , Wada I. , Nagasawa K. , Moriyama T. , Okawa K. , Nagata K.
      J. Biol. Chem.283:20914-20924(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ERAD;SUBCELLULAR LOCATION;GLYCOSYLATION;INTERACTION WITH HSPA5; OS9; SEL1L AND SYVN1
    10. 10.
      "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."
      Christianson J.C. , Shaler T.A. , Tyler R.E. , Kopito R.R.
      Nat. Cell Biol.10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HSPA5; SEL1L AND SYVN1;MUTAGENESIS OF ARG-207 AND ARG-428
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