ESPL1 ELISA Kit for Human(Homo sapiens) | EIAab.comESPL1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ESPL1(Gene name) > Human

ESPL1 (Gene name),

Separin (Protein name ), ESPL1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ESPL1(ESP1;KIAA0165);

Protein name:

Separin;

Alternative:

Extra spindle poles-like 1 protein;Caspase-like protein ESPL1;Separase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PTTG1. Interacts with RAD21.

Function:

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

2120

Sequence:

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2120:

RLKYLIGAAP | IAYGLPVSLR |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

604143

UniGene:

Hs.153479

Pfam:

PF03568

STRING:

9606.ENSP00000257934

String:

Q14674

KEGG:

hsa:9700

Uniprot:

Q14674

FOR

ELISA Kit for Human Separin

Cat.:

E15160h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human Separin

Cat.:

E15160m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Separin

Cat.:

U15160h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Separin

Cat.:

U15160m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Separin

Cat.:

P15160Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Separin

Cat.:

P15160Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Separin

Protein for Human Separin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Regulation of human separase by securin binding and autocleavage."
Waizenegger I. , Gimenez-Abian J.F. , Wernic D. , Peters J.-M.
Curr. Biol.12:1368-1378(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ENZYME REGULATION;AUTOCATALYTIC CLEAVAGE;MUTAGENESIS OF CYS-2029; 1483-GLU--ARG-1486; 1503-GLU--ARG-1506 AND 1532-GLU--ARG-1535
2.

"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Bone marrow.
3.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis."
Zou H. , McGarry T.J. , Bernal T. , Kirschner M.W.
Science285:418-422(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PTTG1
5.

"Dual inhibition of sister chromatid separation at metaphase."
Stemmann O. , Zou H. , Gerber S.A. , Gygi S.P. , Kirschner M.W.
Cell107:715-726(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1117-1130;ENZYME REGULATION;PHOSPHORYLATION AT SER-1126
6.

"Anaphase specific auto-cleavage of separase."
Zou H. , Stemman O. , Anderson J.S. , Mann M. , Kirschner M.W.
FEBS Lett.528:246-250(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1507-1517;ENZYME REGULATION;AUTOCATALYTIC CLEAVAGE;MUTAGENESIS OF ARG-1486; ARG-1506 AND ARG-1535
7.

"Cohesin cleavage by separase required for anaphase and cytokinesis in human cells."
Hauf S. , Waizenegger I.C. , Peters J.-M.
Science293:1320-1323(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAD21
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1396; SER-1399 AND SER-1508;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1396 AND SER-1399;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1508;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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