Protein name:
Eyes absent homolog 4 ;
Alternative:
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
RKLAFRYRRV | KELYNTYKNN | IGGLLGPAKR | DAWLQLRAEI | EALTDSWLTN |
100:
ALKSLSIIST | RSNCVNVLVT | TTQLIPALAK | VLLYSLGGAF | PIENIYSATK |
119:
IGKESCFERI | VSRFGTNIT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Human
ELISA Kit for Chicken Eyes absent homolog 4
ELISA Kit for Chicken Eyes absent homolog 4
ELISA Kit for Chicken Eyes absent homolog 4
CLIA Kit for Chicken Eyes absent homolog 4
CLIA Kit for Chicken Eyes absent homolog 4
CLIA Kit for Chicken Eyes absent homolog 4
Polyclonal Antibody for Chicken Eyes absent homolog 4
Polyclonal Antibody for Chicken Eyes absent homolog 4
Polyclonal Antibody for Chicken Eyes absent homolog 4
Monoclonal Antibody for Chicken Eyes absent homolog 4
Monoclonal Antibody for Chicken Eyes absent homolog 4
Monoclonal Antibody for Chicken Eyes absent homolog 4
Protein for Chicken Eyes absent homolog 4
Protein for Chicken Eyes absent homolog 4
Protein for Chicken Eyes absent homolog 4
R&D Technical Data
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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References
1.
"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G.
,
DeGrandi A.
,
Ballabio A.
,
Bulfone A.
,
Bernard L.
,
Banfi S.
,
Gattuso C.
,
Mariani M.
,
Dixon M.
,
Donnai D.
,
Metcalfe K.
,
Winter R.
,
Robertson M.
,
Axton R.
,
Brown A.
,
van Heyningen V.
,
Hanson I.
Hum. Mol. Genet.8:11-23(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Embryo .