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Index > Protein center > EYA4(Gene name) > Human
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  • EYA4 (Gene name),
  • Eyes absent homolog 4 (Protein name ),  EYA4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EYA4;
    Protein name:
    Eyes absent homolog 4;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    639
    Sequence:
    50:
    MEDSQDLNEQ | SVKKTCTESD | VSQSQNSRSM | EMQDLASPHT | LVGGGDTPGS | 
    100:
    SKLEKSNLSS | TSVTTNGTGG | ENMTVLNTAD | WLLSCNTPSS | ATMSLLAVKT | 
    150:
    EPLNSSETTA | TTGDGALDTF | TGSVITSSGY | SPRSAHQYSP | QLYPSKPYPH | 
    200:
    ILSTPAAQTM | SAYAGQTQYS | GMQQPAVYTA | YSQTGQPYSL | PTYDLGVMLP | 
    250:
    AIKTESGLSQ | TQSPLQSGCL | SYSPGFSTPQ | PGQTPYSYQM | PGSSFAPSST | 
    300:
    IYANNSVSNS | TNFSGSQQDY | PSYTAFGQNQ | YAQYYSASTY | GAYMTSNNTA | 
    350:
    DGTPSSTSTY | QLQESLPGLT | NQPGEFDTMQ | SPSTPIKDLD | ERTCRSSGSK | 
    400:
    SRGRGRKNNP | SPPPDSDLER | VFVWDLDETI | IVFHSLLTGS | YAQKYGKDPP | 
    450:
    MAVTLGLRME | EMIFNLADTH | LFFNDLEECD | QVHIDDVSSD | DNGQDLSTYS | 
    500:
    FATDGFHAAA | SSANLCLPTG | VRGGVDWMRK | LAFRYRRVKE | LYNTYKNNVG | 
    550:
    GLLGPAKRDA | WLQLRAEIEG | LTDSWLTNAL | KSLSIISTRS | NCINVLVTTT | 
    600:
    QLIPALAKVL | LYSLGGAFPI | ENIYSATKIG | KESCFERIMQ | RFGRKVVYVV | 
    639:
    IGDGVEEEQA | AKKHNMPFWR | ISSHSDLLAL | HQALELEYL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Eyes absent homolog 4
    ELISA Kit for Human Eyes absent homolog 4
    ELISA Kit for Human Eyes absent homolog 4
    CLIA Kit for Human Eyes absent homolog 4
    CLIA Kit for Human Eyes absent homolog 4
    CLIA Kit for Human Eyes absent homolog 4
    Polyclonal Antibody for Human Eyes absent homolog 4
    Polyclonal Antibody for Human Eyes absent homolog 4
    Polyclonal Antibody for Human Eyes absent homolog 4
    Monoclonal Antibody for Human Eyes absent homolog 4
    Monoclonal Antibody for Human Eyes absent homolog 4
    Monoclonal Antibody for Human Eyes absent homolog 4
    Protein for Human Eyes absent homolog 4
    Protein for Human Eyes absent homolog 4
    Protein for Human Eyes absent homolog 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT SER-277;ALTERNATIVE SPLICING
      tissue: Lens epithelium.
      tissue: Skeletal muscle.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Testis.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 5.
      "Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus."
      Wayne S. , Robertson N.G. , DeClau F. , Chen N. , Verhoeven K. , Prasad S. , Tranebjaerg L. , Morton C.C. , Ryan A.F. , Van Camp G. , Smith R.J.H.
      Hum. Mol. Genet.10:195-200(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DFNA10
    6. 6.
      "Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss."
      Schoenberger J. , Wang L. , Shin J.T. , Kim S.D. , Depreux F.F.S. , Zhu H. , Zon L. , Pizard A. , Kim J.B. , Macrae C.A. , Mungall A.J. , Seidman J.G. , Seidman C.E.
      Nat. Genet.37:418-422(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CMD1J;TISSUE SPECIFICITY
    7. 7.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally."
      Abe Y. , Oka A. , Mizuguchi M. , Igarashi T. , Ishikawa S. , Aburatani H. , Yokoyama S. , Asahara H. , Nagao K. , Yamada M. , Miyashita T.
      Hum. Mutat.30:E946-E955(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIX3
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-152 AND ASN-301
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