Protein name:
Eyes absent homolog 4 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MEDSQDLNEQ | SVKKTCTESD | VSQSQNSRSM | EMQDLASPHT | LVGGGDTPGS |
100:
SKLEKSNLSS | TSVTTNGTGG | ENMTVLNTAD | WLLSCNTPSS | ATMSLLAVKT |
150:
EPLNSSETTA | TTGDGALDTF | TGSVITSSGY | SPRSAHQYSP | QLYPSKPYPH |
200:
ILSTPAAQTM | SAYAGQTQYS | GMQQPAVYTA | YSQTGQPYSL | PTYDLGVMLP |
250:
AIKTESGLSQ | TQSPLQSGCL | SYSPGFSTPQ | PGQTPYSYQM | PGSSFAPSST |
300:
IYANNSVSNS | TNFSGSQQDY | PSYTAFGQNQ | YAQYYSASTY | GAYMTSNNTA |
350:
DGTPSSTSTY | QLQESLPGLT | NQPGEFDTMQ | SPSTPIKDLD | ERTCRSSGSK |
400:
SRGRGRKNNP | SPPPDSDLER | VFVWDLDETI | IVFHSLLTGS | YAQKYGKDPP |
450:
MAVTLGLRME | EMIFNLADTH | LFFNDLEECD | QVHIDDVSSD | DNGQDLSTYS |
500:
FATDGFHAAA | SSANLCLPTG | VRGGVDWMRK | LAFRYRRVKE | LYNTYKNNVG |
550:
GLLGPAKRDA | WLQLRAEIEG | LTDSWLTNAL | KSLSIISTRS | NCINVLVTTT |
600:
QLIPALAKVL | LYSLGGAFPI | ENIYSATKIG | KESCFERIMQ | RFGRKVVYVV |
639:
IGDGVEEEQA | AKKHNMPFWR | ISSHSDLLAL | HQALELEYL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Human
ELISA Kit for Human Eyes absent homolog 4
ELISA Kit for Human Eyes absent homolog 4
ELISA Kit for Human Eyes absent homolog 4
CLIA Kit for Human Eyes absent homolog 4
CLIA Kit for Human Eyes absent homolog 4
CLIA Kit for Human Eyes absent homolog 4
Polyclonal Antibody for Human Eyes absent homolog 4
Polyclonal Antibody for Human Eyes absent homolog 4
Polyclonal Antibody for Human Eyes absent homolog 4
Monoclonal Antibody for Human Eyes absent homolog 4
Monoclonal Antibody for Human Eyes absent homolog 4
Monoclonal Antibody for Human Eyes absent homolog 4
Protein for Human Eyes absent homolog 4
Protein for Human Eyes absent homolog 4
Protein for Human Eyes absent homolog 4
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G.
,
DeGrandi A.
,
Ballabio A.
,
Bulfone A.
,
Bernard L.
,
Banfi S.
,
Gattuso C.
,
Mariani M.
,
Dixon M.
,
Donnai D.
,
Metcalfe K.
,
Winter R.
,
Robertson M.
,
Axton R.
,
Brown A.
,
van Heyningen V.
,
Hanson I.
Hum. Mol. Genet.8:11-23(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT SER-277;ALTERNATIVE SPLICING
tissue :
Lens epithelium .
tissue :
Skeletal muscle .
2.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue :
Testis .
3.
"The DNA sequence and analysis of human chromosome 6."
Mungall A.J.
,
Palmer S.A.
,
Sims S.K.
,
Edwards C.A.
,
Ashurst J.L.
,
Wilming L.
,
Jones M.C.
,
Horton R.
,
Hunt S.E.
,
Scott C.E.
,
Gilbert J.G.R.
,
Clamp M.E.
,
Bethel G.
,
Milne S.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews T.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Blakey S.E.
,
Bray-Allen S.
,
Brook J.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clark G.
,
Clee C.M.
,
Clegg S.
,
Cobley V.
,
Collier R.E.
,
Collins J.E.
,
Colman L.K.
,
Corby N.R.
,
Coville G.J.
,
Culley K.M.
,
Dhami P.
,
Davies J.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.E.
,
Evans K.A.
,
Faulkner L.
,
Francis M.D.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Ghori M.J.
,
Gilby L.M.
,
Gillson C.J.
,
Glithero R.J.
,
Grafham D.V.
,
Grant M.
,
Gribble S.
,
Griffiths C.
,
Griffiths M.N.D.
,
Hall R.
,
Halls K.S.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Heathcott R.
,
Holmes S.J.
,
Howden P.J.
,
Howe K.L.
,
Howell G.R.
,
Huckle E.
,
Humphray S.J.
,
Humphries M.D.
,
Hunt A.R.
,
Johnson C.M.
,
Joy A.A.
,
Kay M.
,
Keenan S.J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.R.
,
Lloyd D.M.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Maslen G.L.
,
Matthews L.
,
McCann O.T.
,
McLaren S.J.
,
McLay K.
,
McMurray A.
,
Moore M.J.F.
,
Mullikin J.C.
,
Niblett D.
,
Nickerson T.
,
Novik K.L.
,
Oliver K.
,
Overton-Larty E.K.
,
Parker A.
,
Patel R.
,
Pearce A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Phillips S.
,
Plumb R.W.
,
Porter K.M.
,
Ramsey Y.
,
Ranby S.A.
,
Rice C.M.
,
Ross M.T.
,
Searle S.M.
,
Sehra H.K.
,
Sheridan E.
,
Skuce C.D.
,
Smith S.
,
Smith M.
,
Spraggon L.
,
Squares S.L.
,
Steward C.A.
,
Sycamore N.
,
Tamlyn-Hall G.
,
Tester J.
,
Theaker A.J.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
White S.S.
,
Whitehead S.L.
,
Whittaker H.
,
Wild A.
,
Willey D.J.
,
Wilmer T.E.
,
Wood J.M.
,
Wray P.W.
,
Wyatt J.C.
,
Young L.
,
Younger R.M.
,
Bentley D.R.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Dunham I.
,
Rogers J.
,
Beck S.
more...
Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
5.
"Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus."
Wayne S.
,
Robertson N.G.
,
DeClau F.
,
Chen N.
,
Verhoeven K.
,
Prasad S.
,
Tranebjaerg L.
,
Morton C.C.
,
Ryan A.F.
,
Van Camp G.
,
Smith R.J.H.
Hum. Mol. Genet.10:195-200(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN DFNA10
6.
"Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss."
Schoenberger J.
,
Wang L.
,
Shin J.T.
,
Kim S.D.
,
Depreux F.F.S.
,
Zhu H.
,
Zon L.
,
Pizard A.
,
Kim J.B.
,
Macrae C.A.
,
Mungall A.J.
,
Seidman J.G.
,
Seidman C.E.
Nat. Genet.37:418-422(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CMD1J;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
"EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally."
Abe Y.
,
Oka A.
,
Mizuguchi M.
,
Igarashi T.
,
Ishikawa S.
,
Aburatani H.
,
Yokoyama S.
,
Asahara H.
,
Nagao K.
,
Yamada M.
,
Miyashita T.
Hum. Mutat.30:E946-E955(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIX3
10.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] ARG-152 AND ASN-301