Protein name:
Ezrin ;
Alternative:
Villin-2 ;Cytovillin ;p81 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS.
Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Subcellular Location:
Apical cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
Cell projection
microvillus membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
ruffle membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
cell cortex
Cytoplasm
cytoskeleton
Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein.
Protein Attributes:
50:
MPKPINVRVT | TMDAELEFAI | QPNTTGKQLF | DQVVKTIGLR | EVWYFGLHYV |
100:
DNKGFPTWLK | LDKKVSAQEV | RKENPLQFKF | RAKFYPEDVA | EELIQDITQK |
150:
LFFLQVKEGI | LSDEIYCPPE | TAVLLGSYAV | QAKFGDYNKE | VHKSGYLSSE |
200:
RLIPQRVMDQ | HKLTRDQWED | RIQVWHAEHR | GMLKDNAMLE | YLKIAQDLEM |
250:
YGINYFEIKN | KKGTDLWLGV | DALGLNIYEK | DDKLTPKIGF | PWSEIRNISF |
300:
NDKKFVIKPI | DKKAPDFVFY | APRLRINKRI | LQLCMGNHEL | YMRRRKPDTI |
350:
EVQQMKAQAR | EEKHQKQLER | QQLETEKKRR | ETVEREKEQM | MREKEELMLR |
400:
LQDYEEKTKK | AERELSEQIQ | RALQLEEERK | RAQEEAERLE | ADRMAALRAK |
450:
EELERQAVDQ | IKSQEQLAAE | LAEYTAKIAL | LEEARRRKED | EVEEWQHRAK |
500:
EAQDDLVKTK | EELHLVMTAP | PPPPPPVYEP | VSYHVQESLQ | DEGAEPTGYS |
550:
AELSSEGIRD | DRNEEKRITE | AEKNERVQRQ | LLTLSSELSQ | ARDENKRTHN |
586:
DIIHNENMRQ | GRDKYKTLRQ | IRQGNTKQRI | DEFEAL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Rabbit
Mouse
ELISA Kit for Human Ezrin
ELISA Kit for Human Ezrin
ELISA Kit for Human Ezrin
ELISA Kit for Human Ezrin
ELISA Kit for Human Ezrin
Polyclonal Antibody for Human Ezrin
Polyclonal Antibody for Human Ezrin
Polyclonal Antibody for Human Ezrin
Polyclonal Antibody for Human Ezrin
Polyclonal Antibody for Human Ezrin
Monoclonal Antibody for Human Ezrin
Monoclonal Antibody for Human Ezrin
Monoclonal Antibody for Human Ezrin
Monoclonal Antibody for Human Ezrin
Monoclonal Antibody for Human Ezrin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT VAL-532
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Melanoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Colon .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 172-180 AND 343-350
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 264-273; 428-435 AND 530-542;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Fetal brain cortex .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-146 AND TYR-354 BY PDGFR
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SLC9A3R1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SCYL3
tissue :
Kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH S100P
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TMEM8B
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PODXL
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PLEKHG6
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FES/FPS;PHOSPHORYLATION AT TYR-146 AND TYR-478;SUBCELLULAR LOCATION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT THR-567
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH S100P
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FEBS Lett.583:2326-2332(2009)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MCC
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-60;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-297