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Index > Protein center > EZR(Gene name) > Human
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  • EZR (Gene name),
  • Ezrin (Protein name ),  EZRI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EZR(VIL2);
    Protein name:
    Ezrin;
    Alternative:
    Villin-2;Cytovillin;p81;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS.
    Function:
    Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
    Subcellular Location:
    Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Cell projection microvillus membrane Peripheral membrane protein Cytoplasmic side Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cell cortex Cytoplasm cytoskeleton Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein.
    Protein Attributes:
    Sequence length:
    586
    Sequence:
    50:
    MPKPINVRVT | TMDAELEFAI | QPNTTGKQLF | DQVVKTIGLR | EVWYFGLHYV | 
    100:
    DNKGFPTWLK | LDKKVSAQEV | RKENPLQFKF | RAKFYPEDVA | EELIQDITQK | 
    150:
    LFFLQVKEGI | LSDEIYCPPE | TAVLLGSYAV | QAKFGDYNKE | VHKSGYLSSE | 
    200:
    RLIPQRVMDQ | HKLTRDQWED | RIQVWHAEHR | GMLKDNAMLE | YLKIAQDLEM | 
    250:
    YGINYFEIKN | KKGTDLWLGV | DALGLNIYEK | DDKLTPKIGF | PWSEIRNISF | 
    300:
    NDKKFVIKPI | DKKAPDFVFY | APRLRINKRI | LQLCMGNHEL | YMRRRKPDTI | 
    350:
    EVQQMKAQAR | EEKHQKQLER | QQLETEKKRR | ETVEREKEQM | MREKEELMLR | 
    400:
    LQDYEEKTKK | AERELSEQIQ | RALQLEEERK | RAQEEAERLE | ADRMAALRAK | 
    450:
    EELERQAVDQ | IKSQEQLAAE | LAEYTAKIAL | LEEARRRKED | EVEEWQHRAK | 
    500:
    EAQDDLVKTK | EELHLVMTAP | PPPPPPVYEP | VSYHVQESLQ | DEGAEPTGYS | 
    550:
    AELSSEGIRD | DRNEEKRITE | AEKNERVQRQ | LLTLSSELSQ | ARDENKRTHN | 
    586:
    DIIHNENMRQ | GRDKYKTLRQ | IRQGNTKQRI | DEFEAL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    SMR:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ezrin
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    E1297h
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    ELISA Kit for Human Ezrin
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    E1297r
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    ELISA Kit for Human Ezrin
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    E1297b
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    ELISA Kit for Human Ezrin
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    ELISA Kit for Human Ezrin
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    E1297m
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    CLIA Kit for Human Ezrin
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    U1297m
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    CLIA Kit for Human Ezrin
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    U1297r
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Ezrin
    Cat.:
    U1297h
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Ezrin
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    CLIA Kit for Human Ezrin
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    U1297b
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    Packing:
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    Polyclonal Antibody for Human Ezrin
    Cat.:
    P1297Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ezrin
    Polyclonal Antibody for Human Ezrin
    Cat.:
    P1297Rb-m
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    Packing:
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    Polyclonal Antibody for Human Ezrin
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    P1297Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ezrin
    Monoclonal Antibody for Human Ezrin
    Monoclonal Antibody for Human Ezrin
    Monoclonal Antibody for Human Ezrin
    Monoclonal Antibody for Human Ezrin
    Monoclonal Antibody for Human Ezrin
    Protein for Human Ezrin
    Protein for Human Ezrin
    Protein for Human Ezrin
    Protein for Human Ezrin
    Protein for Human Ezrin

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    Linearity
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    References
    1. 1.
      "Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization."
      Turunen O. , Winqvist R. , Pakkanen R. , Grzeschik K.-H. , Wahlstroem T. , Vaheri A.
      J. Biol. Chem.264:16727-16732(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-532
      tissue: Placenta.
    2. 2.
      "cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1."
      Gould K.L. , Bretscher A. , Esch F.S. , Hunter T.
      EMBO J.8:4133-4142(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT VAL-532
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Melanoma.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    7. 7.
      "Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes."
      Egerton M. , Moritz R.L. , Druker B. , Kelso A. , Simpson R.J.
      Biochem. Biophys. Res. Commun.224:666-674(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 172-180 AND 343-350
    8. 8.
      Lubec G. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 264-273; 428-435 AND 530-542;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Fetal brain cortex.
    9. 9.
      "Identification of the two major epidermal growth factor-induced tyrosine phosphorylation sites in the microvillar core protein ezrin."
      Krieg J. , Hunter T.
      J. Biol. Chem.267:19258-19265(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-146 AND TYR-354 BY PDGFR
    10. 10.
      "Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells."
      Egerton M. , Burgess W.H. , Chen D. , Druker B.J. , Bretscher A. , Samelson L.E.
      J. Immunol.149:1847-1852(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    11. 11.
      "Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family."
      Reczek D. , Berryman M. , Bretscher A.
      J. Cell Biol.139:169-179(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC9A3R1
    12. 12.
      "PACE-1, a novel protein that interacts with the C-terminal domain of ezrin."
      Sullivan A. , Uff C.R. , Isacke C.M. , Thorne R.F.
      Exp. Cell Res.284:224-238(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCYL3
      tissue: Kidney.
    13. 13.
      "Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P."
      Koltzscher M. , Neumann C. , Konig S. , Gerke V.
      Mol. Biol. Cell14:2372-2384(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100P
    14. 14.
      "Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells."
      Ma J. , Zhou J. , Fan S. , Wang L.-L. , Li X.-L. , Yan Q. , Zhou M. , Liu H.-Y. , Zhang Q. , Zhou H. , Gan K. , Li Z. , Peng C. , Xiong W. , Tan C. , Shen S.-R. , Yang J. , Li J. , more...
      Carcinogenesis26:281-291(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM8B
    15. 15.
      "Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system."
      Groenholm M. , Teesalu T. , Tyynelaa J. , Piltti K. , Boehling T. , Wartiovaara K. , Vaheri A. , Carpen O.
      Mol. Cell. Neurosci.28:683-693(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    16. 16.
      "Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin."
      Sizemore S. , Cicek M. , Sizemore N. , Ng K.P. , Casey G.
      Cancer Res.67:6183-6191(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PODXL
    17. 17.
      "Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells."
      D'Angelo R. , Aresta S. , Blangy A. , Del Maestro L. , Louvard D. , Arpin M.
      Mol. Biol. Cell18:4780-4793(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PLEKHG6
    18. 18.
      "Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering."
      Naba A. , Reverdy C. , Louvard D. , Arpin M.
      EMBO J.27:38-50(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FES/FPS;PHOSPHORYLATION AT TYR-146 AND TYR-478;SUBCELLULAR LOCATION
    19. 19.
      "Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells."
      Wald F.A. , Oriolo A.S. , Mashukova A. , Fregien N.L. , Langshaw A.H. , Salas P.J.
      J. Cell Sci.121:644-654(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-567
    20. 20.
      "Generation and characterization of a novel, permanently active S100P mutant."
      Austermann J. , Nazmi A.R. , Heil A. , Fritz G. , Kolinski M. , Filipek S. , Gerke V.
      Biochim. Biophys. Acta1793:1078-1085(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH S100P
    21. 21.
      "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."
      Arnaud C. , Sebbagh M. , Nola S. , Audebert S. , Bidaut G. , Hermant A. , Gayet O. , Dusetti N.J. , Ollendorff V. , Santoni M.J. , Borg J.P. , Lecine P.
      FEBS Lett.583:2326-2332(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCC
    22. 22.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-60;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions."
      Smith W.J. , Nassar N. , Bretscher A. , Cerione R.A. , Karplus P.A.
      J. Biol. Chem.278:4949-4956(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-297
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