F10 ELISA Kit for Human(Homo sapiens) | EIAab.comF10 ELISA Kit for Human(Homo sapiens)

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F10 (Gene name),

Coagulation factor X (Protein name ), FA10_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

F10;

Protein name:

Coagulation factor X;

Alternative:

Stuart-Prower factor;Stuart factor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds.

Function:

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

488

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

488:

IYTKVTAFLK | WIDRSMKTRG | LPKAKSHAPE | VITSSPLK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00008

STRING:

9606.ENSP00000364709

UniGene:

Hs.361463

String:

P00742

KEGG:

hsa:2159

SMR:

P00742

MIM:

227600

Uniprot:

P00742

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ELISA Kit for Human Coagulation factor X

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E0834h

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96T

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ELISA Kit for Human Coagulation factor X

Cat.:

E0834r

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96T

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ELISA Kit for Human Coagulation factor X

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ELISA Kit for Human Coagulation factor X

Cat.:

E0834m

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96T

ELISA Kit for Human Coagulation factor X

Cat.:

E0834b

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96T

ELISA Kit for Human Coagulation factor X

Cat.:

E0834c

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96T

CLIA Kit for Human Coagulation factor X

Cat.:

U0834m

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96T

CLIA Kit for Human Coagulation factor X

Cat.:

U0834b

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96T

CLIA Kit for Human Coagulation factor X

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CLIA Kit for Human Coagulation factor X

Cat.:

U0834c

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96T

CLIA Kit for Human Coagulation factor X

Cat.:

U0834r

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Looking for manual.

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96T

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CLIA Kit for Human Coagulation factor X

Cat.:

U0834h

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Polyclonal Antibody for Human Coagulation factor X

Cat.:

P0834Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor X

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P0834Rb-m

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Polyclonal Antibody for Human Coagulation factor X

Cat.:

P0834Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Coagulation factor X

Protein for Human Coagulation factor X

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X."
Messier T.L. , Pittman D.D. , Long G.L. , Kaufman R.J. , Church W.R.
Gene99:291-294(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C."
Leytus S.P. , Foster D.C. , Kurachi K. , Davie E.W.
Biochemistry25:5098-5102(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

SeattleSNPs variation discovery resource
Submitted (2002-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-152 AND ARG-192
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Ovary.
5.

"Characterization of an almost full-length cDNA coding for human blood coagulation factor X."
Fung M.R. , Hay C.W. , McGillivray R.T.A.
Proc. Natl. Acad. Sci. U.S.A.82:3591-3595(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-488
6.

"Isolation and characterization of human blood-coagulation factor X cDNA."
Kaul R.K. , Hildebrand B. , Roberts S. , Jagadeeswaran P.
Gene41:311-314(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-488
tissue: Liver.
7.

"Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid."
McMullen B.A. , Fujikawa K. , Kisiel W. , Sasagawa T. , Howald W.N. , Kwa E.Y. , Weinstein B.
Biochemistry22:2875-2884(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 41-179;HYDROXYLATION AT ASP-103;GAMMA-CARBOXYGLUTAMATION AT GLU-46; GLU-47; GLU-54; GLU-56; GLU-59; GLU-60; GLU-65; GLU-66; GLU-69; GLU-72 AND GLU-79
8.

"Characterization of a cDNA coding for human factor X."
Leytus S.P. , Chung D.W. , Kisiel W. , Kurachi K. , Davie E.W.
Proc. Natl. Acad. Sci. U.S.A.81:3699-3702(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 115-488;TISSUE SPECIFICITY
tissue: Liver.
9.

"Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X."
Inoue K. , Morita T.
Eur. J. Biochem.218:153-163(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 183-234;GLYCOSYLATION AT THR-199; THR-211; ASN-221 AND ASN-231
10.

"Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X."
Jagadeeswaran P. , Reddy S.V. , Rao K.J. , Hamsabhushanam K. , Lyman G.
Gene84:517-519(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23
11.

"Mechanism of inhibition of activated protein C by protein C inhibitor."
Suzuki K. , Nishioka J. , Kusumoto H. , Hashimoto S.
J. Biochem.95:187-195(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
12.

"Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa."
Huang X. , Dementiev A. , Olson S.T. , Gettins P.G.
J. Biol. Chem.285:20399-20409(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
13.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
14.

"Structure of human des(1-45) factor Xa at 2.2-A resolution."
Padmanabhan K. , Padmanabhan K.P. , Tulinsky A. , Park C.H. , Bode W. , Huber R. , Blankenship D.T. , Cardin A.D. , Kisiel W.
J. Mol. Biol.232:947-966(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 86-179 AND 235-278
15.

"Structural basis for chemical inhibition of human blood coagulation factor Xa."
Kamata K. , Kawamoto H. , Honma T. , Iwama T. , Kim S.H.
Proc. Natl. Acad. Sci. U.S.A.95:6630-6635(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 86-179 AND 235-278
16.

"Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa."
Kochanny M.J. , Adler M. , Ewing J. , Griedel B.D. , Ho E. , Karanjawala R. , Lee W. , Lentz D. , Liang A.M. , Morrissey M.M. , Phillips G.B. , Post J. , Sacchi K.L. , Sakata S.T. , Subramanyam B. , Vergona R. , Walters J. , White K.A. , more...
Bioorg. Med. Chem.15:2127-2146(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 127-467
17.

"Molecular characterization of human factor XSan Antonio."
Reddy S.V. , Zhou Z.Q. , Rao K.J. , Scott J.P. , Watzke H. , High K.A. , Jagadeeswaran P.
Blood74:1486-1490(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D CYS-366
18.

"Molecular defect (Gla+14TO: hereditary factor X deficiency (factor X 'Vorarlberg')."
Watzke H.H. , Lechner K. , Roberts H.R. , Reddy S.V. , Welsch D.J. , Friedman P. , Mahr G. , Jagadeeswaran P. , Monroe D.M. , High K.A.
J. Biol. Chem.265:11982-11989(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA10D LYS-54 AND LYS-142;CHARACTERIZATION OF VARIANT FA10D LYS-54
19.

"Molecular defect in coagulation factor XFriuli results from a substitution of serine for proline at position 343."
James H.L. , Girolami A. , Fair D.S.
Blood77:317-323(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D SER-383
20.

"Molecular bases of CRM+ factor X deficiency: a frequent mutation (Ser334Pro) in the catalytic domain and a substitution (Glu102Lys) in the second EGF-like domain."
Marchetti G. , Castaman G. , Pinotti M. , Lunghi B. , Di Iasio M.G. , Ruggieri M. , Rodeghiero F. , Bernardi F.
Br. J. Haematol.90:910-915(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA10D LYS-142 AND PRO-374
21.

"Functional consequences of the Ser334-->Pro mutation in a human factor X variant (factor XMarseille)."
Bezeaud A. , Miyata T. , Helley D. , Zeng Y.Z. , Kato H. , Aillaud M.F. , Juhan-Vague I. , Guillin M.C.
Eur. J. Biochem.234:140-147(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D PRO-374;CHARACTERIZATION OF VARIANT FA10D PRO-374
22.

"Factor XKetchikan: a variant molecule in which Gly replaces a Gla residue at position 14 in the light chain."
Kim D.J. , Thompson A.R. , James H.L.
Hum. Genet.95:212-214(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D GLY-54
23.

"Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X."
Messier T.L. , Wong C.Y. , Bovill E.G. , Long G.L. , Church W.R.
Blood Coagul. Fibrinolysis7:5-14(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D ASN-322;CHARACTERIZATION OF VARIANT FA10D ASN-322
24.

"Factor XSt. Louis II. Identification of a glycine substitution at residue 7 and characterization of the recombinant protein."
Rudolph A.E. , Mullane M.P. , Porche-Sorbet R. , Tsuda S. , Miletich J.P.
J. Biol. Chem.271:28601-28606(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D GLY-47
25.

"A family with hereditary factor X deficiency with a point mutation Gla32 to Gln in the Gla domain (factor X Tokyo)."
Zama T. , Murata M. , Watanabe R. , Yokoyama K. , Moriki T. , Ambo H. , Murakami H. , Kikuchi M. , Ikeda Y.
Br. J. Haematol.106:809-811(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D GLN-72
26.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-7 AND HIS-30
27.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
28.

"Molecular analysis of the genotype-phenotype relationship in factor X deficiency."
Millar D.S. , Elliston L. , Deex P. , Krawczak M. , Wacey A.I. , Reynaud J. , Nieuwenhuis H.K. , Bolton-Maggs P. , Mannucci P.M. , Reverter J.C. , Cachia P. , Pasi K.J. , Layton D.M. , Cooper D.N.
Hum. Genet.106:249-257(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA10D LYS-54; TYR-149; TYR-151; ARG-289; LYS-304; TRP-327; MET-338; LYS-350; MET-358; SER-363 AND ARG-404
29.

"The impact of Glu102Lys on the factor X function in a patient with a doubly homozygous factor X deficiency (Gla14Lys and Glu102Lys)."
Forberg E. , Huhmann I. , Jimenez-Boj E. , Watzke H.H.
Thromb. Haemost.83:234-238(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT FA10D LYS-142
30.

"A dysfunctional factor X (factor X San Giovanni Rotondo) present at homozygous and double heterozygous level: identification of a novel microdeletion (delC556) and missense mutation (Lys(408)-->Asn) in the factor X gene. A study of an Italian family."
Simioni P. , Vianello F. , Kalafatis M. , Barzon L. , Ladogana S. , Paolucci P. , Carotenuto M. , Dal Bello F. , Palu G. , Girolami A.
Thromb. Res.101:219-230(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D ASN-448
31.

"A new factor X defect (factor X Padua 3): a compound heterozygous between true deficiency (Gly(380)-->Arg) and an abnormality (Ser(334)-->Pro)."
Vianello F. , Lombardi A.M. , Boldrin C. , Luni S. , Girolami A.
Thromb. Res.104:257-264(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA10D PRO-374 AND ARG-420
32.

"A novel type I factor X variant (factor X Cys350Phe) due to loss of a disulfide bond in the catalytic domain."
Vianello F. , Lombardi A.M. , Bello F.D. , Palu G. , Zanon E. , Girolami A.
Blood Coagul. Fibrinolysis14:401-405(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D PHE-390
33.

"Genetic analysis of hereditary factor X deficiency in a French patient of Sri Lankan ancestry: in vitro expression study identified Gly366Ser substitution as the molecular basis of the dysfunctional factor X."
Isshiki I. , Favier R. , Moriki T. , Uchida T. , Ishihara H. , Van Dreden P. , Murata M. , Ikeda Y.
Blood Coagul. Fibrinolysis16:9-16(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D SER-406;CHARACTERIZATION OF VARIANT FA10D SER-406
34.

"Analysis of the novel factor X gene mutation Glu51Lys in two families with factor X-Riyadh anomaly."
Al-Hilali A. , Wulff K. , Abdel-Razeq H. , Saud K.A. , Al-Gaili F. , Herrmann F.H.
Thromb. Haemost.97:542-545(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D LYS-91
35.

"Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X."
Chafa O. , Tagzirt M. , Tapon-Bretaudiere J. , Reghis A. , Fischer A.M. , LeBonniec B.F.
Thromb. Res.124:144-148(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA10D VAL-51

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