F11 ELISA Kit for Human(Homo sapiens) | EIAab.comF11 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > F11(Gene name) > Human

F11 (Gene name),

Coagulation factor XI (Protein name ), FA11_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

F11;

Protein name:

Coagulation factor XI(FXI);

Alternative:

Plasma thromboplastin antecedent(PTA);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.

Function:

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

625

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

625:

QRERPGVYTN | VVEYVDWILE | KTQAV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P03951

UniGene:

Hs.1430

KEGG:

hsa:2160

STRING:

9606.ENSP00000264691

Pfam:

PF00024

SMR:

P03951

MIM:

264900

Uniprot:

P03951

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ELISA Kit for Human FXI

Cat.:

E0850m

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Packing:

96T

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ELISA Kit for Human FXI

Cat.:

E0850h

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Packing:

96T

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ELISA Kit for Human FXI

Cat.:

E0850b

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MSDS:

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Packing:

96T

CLIA Kit for Human FXI

Cat.:

U0850b

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MSDS:

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Packing:

96T

CLIA Kit for Human FXI

Cat.:

U0850h

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

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CLIA Kit for Human FXI

Cat.:

U0850m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human FXI

Cat.:

P0850Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human FXI

Cat.:

P0850Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human FXI

Protein for Human FXI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein."
Fujikawa K. , Chung D.W. , Hendrickson L.E. , Davie E.W.
Biochemistry25:2417-2424(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Organization of the gene for human factor XI."
Asakai R. , Davie E.W. , Chung D.W.
Biochemistry26:7221-7228(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
3.

"Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene."
Hsu T.-C. , Shore S.K. , Seshsmma T. , Bagasra O. , Walsh P.N.
J. Biol. Chem.273:13787-13793(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

SeattleSNPs variation discovery resource
Submitted (2002-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-339
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains."
McMullen B.A. , Fujikawa K. , Davie E.W.
Biochemistry30:2056-2060(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS
9.

"Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
Meijers J.C. , Kanters D.H. , Vlooswijk R.A. , van Erp H.E. , Hessing M. , Bouma B.N.
Biochemistry27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
10.

"Localization of a heparin binding site in the catalytic domain of factor XIa."
Badellino K.O. , Walsh P.N.
Biochemistry40:7569-7580(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARIN-BINDING SITE
11.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-126; ASN-450 AND ASN-491
tissue: Plasma.
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-450 AND ASN-491
tissue: Liver.
13.

"Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa."
Buchanan M.S. , Carroll A.R. , Wessling D. , Jobling M. , Avery V.M. , Davis R.A. , Feng Y. , Xue Y. , Oster L. , Fex T. , Deinum J. , Hooper J.N. , Quinn R.J.
J. Med. Chem.51:3583-3587(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 388-625 IN COMPLEX WITH INHIBITOR;DISULFIDE BONDS
14.

"Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations."
Asakai R. , Chung D.W. , Ratnoff O.D. , Davie E.W.
Proc. Natl. Acad. Sci. U.S.A.86:7667-7671(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LEU-301
15.

"Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency."
Meijers J.C. , Davie E.W. , Chung D.W.
Blood79:1435-1440(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LEU-301
16.

"Six point mutations that cause factor XI deficiency."
Pugh R.E. , McVey J.H. , Tuddenham E.G. , Hancock J.F.
Blood85:1509-1516(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D HIS-34; PRO-320; ILE-322 AND LYS-341
17.

"Identification of two novel mutations in non-Jewish factor XI deficiency."
Imanaka Y. , Lal K. , Nishimura T. , Bolton-Maggs P.H. , Tuddenham E.G. , McVey J.H.
Br. J. Haematol.90:916-920(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D VAL-460
18.

"Severe factor XI deficiency in an Arab family associated with a novel mutation in exon 11."
Wistinghausen B. , Reischer A. , Oddoux C. , Ostrer H. , Nardi M. , Karpatkin M.
Br. J. Haematol.99:575-577(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ASN-404
19.

"Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting."
Martincic D. , Zimmerman S.A. , Ware R.E. , Sun M.-F. , Whitlock J.A. , Gailani D.
Blood92:3309-3317(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ASN-266;VARIANT ARG-244
20.

Martincic D. , Zimmerman S.A. , Ware R.E. , Sun M.-F. , Whitlock J.A. , Gailani D.
Blood93:1786-1786(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
21.

"Identification of a novel mutation in a non-Jewish factor XI deficient kindred."
Alhaq A. , Mitchell M. , Sethi M. , Rahman S. , Flynn G. , Boulton P. , Caeno G. , Smith M. , Savidge G.
Br. J. Haematol.104:44-49(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D CYS-246
22.

"Heterozygous factor XI deficiency associated with three novel mutations."
Mitchell M. , Cutler J. , Thompson S. , Moore G. , Jenkins Ap Rees E. , Smith M. , Savidge G. , Alhaq A.
Br. J. Haematol.107:763-765(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D CYS-326; VAL-430 ILE-493 AND ARG-594
23.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-66; ARG-244; PHE-308 AND PHE-339
24.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
25.

"Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene."
Zivelin A. , Bauduer F. , Ducout L. , Peretz H. , Rosenberg N. , Yatuv R. , Seligsohn U.
Blood99:2448-2454(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ARG-56; TYR-255 AND HIS-511;VARIANT PHE-339;CHARACTERIZATION OF VARIANTS FA11D ARG-56; TYR-255 AND HIS-511
26.

"Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain."
Kravtsov D.V. , Wu W. , Meijers J.C.M. , Sun M.-F. , Blinder M.A. , Dang T.P. , Wang H. , Gailani D.
Blood104:128-134(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D VAL-418 AND SER-587;CHARACTERIZATION OF VARIANTS FA11D VAL-418 AND SER-587
27.

"Severe factor XI deficiency caused by compound heterozygosity."
Dai L. , Mitchell M. , Carson P. , Creagh D. , Cutler J. , Savidge G. , Alhaq A.
Br. J. Haematol.125:817-818(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ILE-270;CHARACTERIZATION OF VARIANT F11 DEFICIENCY ILE-270
28.

"Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion."
Hill M. , McLeod F. , Franks H. , Gordon B. , Dolan G.
Br. J. Haematol.129:825-829(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D PHE-46; ARG-101; CYS-151; GLU-263; VAL-430; LEU-538; LYS-565 AND SER-618
29.

"Identification of five novel mutations in the factor XI gene (F11) of patients with factor XI deficiency."
Quelin F. , Mathonnet F. , Potentini-Esnault C. , Trigui N. , Peynet J. , Bastenaire B. , Guillon L. , Bigel M.L. , Sauger A. , Mazurier C. , de Mazancourt P.
Blood Coagul. Fibrinolysis17:69-73(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D TYR-140; LYS-315 AND LYS-597
30.

"Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients."
Fard-Esfahani P. , Lari G.R. , Ravanbod S. , Mirkhani F. , Allahyari M. , Rassoulzadegan M. , Ala F.
Haemophilia14:91-95(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ILE-51; PRO-51; ILE-331; PRO-360; PRO-503 AND HIS-608
31.

"Population-specific spectrum of the F11 mutations in Koreans: evidence for a founder effect."
Kim J. , Song J. , Lyu C. , Kim Y. , Oh S. , Choi Y. , Yoo J. , Choi J. , Kim H. , Lee K.A.
Clin. Genet.82:180-186(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ARG-32; GLN-53; THR-252; ARG-401 AND GLU-526
32.

"Three dominant-negative mutations in factor XI-deficient patients."
Dai L. , Rangarajan S. , Mitchell M.
Haemophilia17:E919-E922(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D THR-43; LEU-241 AND MET-403;CHARACTERIZATION OF VARIANTS FA11D THR-43; LEU-241 AND MET-403
33.

"A novel missense mutation Asp506Gly in exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency."
Lee J.H. , Cho H.S. , Hyun M.S. , Kim H.Y. , Kim H.J.
Korean J. Lab. Med.31:290-293(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D GLY-506
34.

"Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency."
Tirefort Y. , Uhr M.R. , Neerman-Arbez M. , de Moerloose P.
Blood Coagul. Fibrinolysis23:251-252(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D SER-481
35.

"A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy."
Girolami A. , Scarparo P. , Bonamigo E. , Santarossa L. , Cristiani A. , Moro S. , Lombardi A.M.
Eur. J. Haematol.88:229-236(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LYS-454
36.

"Revisiting the molecular epidemiology of factor XI deficiency: nine new mutations and an original large 4qTer deletion in western Brittany (France)."
Gueguen P. , Chauvin A. , Quemener-Redon S. , Pan-Petesch B. , Ferec C. , Abgrall J.F. , Le Marechal C.
Thromb. Haemost.107:44-50(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D PRO-51; ARG-56; VAL-63; TYR-222; GLN-228; CYS-276; ASP-277; PHE-514; LEU-575 AND LYS-597

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