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Index > Protein center > F11(Gene name) > Human
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  • F11 (Gene name),
  • Coagulation factor XI (Protein name ),  FA11_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    F11;
    Protein name:
    Coagulation factor XI(FXI);
    Alternative:
    Plasma thromboplastin antecedent(PTA);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.
    Function:
    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    625
    Sequence:
    50:
    MIFLYQVVHF | ILFTSVSGEC | VTQLLKDTCF | EGGDITTVFT | PSAKYCQVVC | 
    100:
    TYHPRCLLFT | FTAESPSEDP | TRWFTCVLKD | SVTETLPRVN | RTAAISGYSF | 
    150:
    KQCSHQISAC | NKDIYVDLDM | KGINYNSSVA | KSAQECQERC | TDDVHCHFFT | 
    200:
    YATRQFPSLE | HRNICLLKHT | QTGTPTRITK | LDKVVSGFSL | KSCALSNLAC | 
    250:
    IRDIFPNTVF | ADSNIDSVMA | PDAFVCGRIC | THHPGCLFFT | FFSQEWPKES | 
    300:
    QRNLCLLKTS | ESGLPSTRIK | KSKALSGFSL | QSCRHSIPVF | CHSSFYHDTD | 
    350:
    FLGEELDIVA | AKSHEACQKL | CTNAVRCQFF | TYTPAQASCN | EGKGKCYLKL | 
    400:
    SSNGSPTKIL | HGRGGISGYT | LRLCKMDNEC | TTKIKPRIVG | GTASVRGEWP | 
    450:
    WQVTLHTTSP | TQRHLCGGSI | IGNQWILTAA | HCFYGVESPK | ILRVYSGILN | 
    500:
    QSEIKEDTSF | FGVQEIIIHD | QYKMAESGYD | IALLKLETTV | NYTDSQRPIC | 
    550:
    LPSKGDRNVI | YTDCWVTGWG | YRKLRDKIQN | TLQKAKIPLV | TNEECQKRYR | 
    600:
    GHKITHKMIC | AGYREGGKDA | CKGDSGGPLS | CKHNEVWHLV | GITSWGEGCA | 
    625:
    QRERPGVYTN | VVEYVDWILE | KTQAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human FXI
    Cat.:
    E0850m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human FXI
    Cat.:
    E0850h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human FXI
    Cat.:
    E0850b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FXI
    Cat.:
    U0850b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FXI
    Cat.:
    U0850h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human FXI
    Cat.:
    U0850m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human FXI
    Polyclonal Antibody for Human FXI
    Cat.:
    P0850Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FXI
    Cat.:
    P0850Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human FXI
    Monoclonal Antibody for Human FXI
    Monoclonal Antibody for Human FXI
    Protein for Human FXI
    Protein for Human FXI
    Protein for Human FXI

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein."
      Fujikawa K. , Chung D.W. , Hendrickson L.E. , Davie E.W.
      Biochemistry25:2417-2424(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Organization of the gene for human factor XI."
      Asakai R. , Davie E.W. , Chung D.W.
      Biochemistry26:7221-7228(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    3. 3.
      "Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene."
      Hsu T.-C. , Shore S.K. , Seshsmma T. , Bagasra O. , Walsh P.N.
      J. Biol. Chem.273:13787-13793(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-339
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains."
      McMullen B.A. , Fujikawa K. , Davie E.W.
      Biochemistry30:2056-2060(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS
    9. 9.
      "Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."
      Meijers J.C. , Kanters D.H. , Vlooswijk R.A. , van Erp H.E. , Hessing M. , Bouma B.N.
      Biochemistry27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
    10. 10.
      "Localization of a heparin binding site in the catalytic domain of factor XIa."
      Badellino K.O. , Walsh P.N.
      Biochemistry40:7569-7580(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARIN-BINDING SITE
    11. 11.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-126; ASN-450 AND ASN-491
      tissue: Plasma.
    12. 12.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-450 AND ASN-491
      tissue: Liver.
    13. 13.
      "Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa."
      Buchanan M.S. , Carroll A.R. , Wessling D. , Jobling M. , Avery V.M. , Davis R.A. , Feng Y. , Xue Y. , Oster L. , Fex T. , Deinum J. , Hooper J.N. , Quinn R.J.
      J. Med. Chem.51:3583-3587(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 388-625 IN COMPLEX WITH INHIBITOR;DISULFIDE BONDS
    14. 14.
      "Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations."
      Asakai R. , Chung D.W. , Ratnoff O.D. , Davie E.W.
      Proc. Natl. Acad. Sci. U.S.A.86:7667-7671(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LEU-301
    15. 15.
      "Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency."
      Meijers J.C. , Davie E.W. , Chung D.W.
      Blood79:1435-1440(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LEU-301
    16. 16.
      "Six point mutations that cause factor XI deficiency."
      Pugh R.E. , McVey J.H. , Tuddenham E.G. , Hancock J.F.
      Blood85:1509-1516(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D HIS-34; PRO-320; ILE-322 AND LYS-341
    17. 17.
      "Identification of two novel mutations in non-Jewish factor XI deficiency."
      Imanaka Y. , Lal K. , Nishimura T. , Bolton-Maggs P.H. , Tuddenham E.G. , McVey J.H.
      Br. J. Haematol.90:916-920(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D VAL-460
    18. 18.
      "Severe factor XI deficiency in an Arab family associated with a novel mutation in exon 11."
      Wistinghausen B. , Reischer A. , Oddoux C. , Ostrer H. , Nardi M. , Karpatkin M.
      Br. J. Haematol.99:575-577(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ASN-404
    19. 19.
      "Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting."
      Martincic D. , Zimmerman S.A. , Ware R.E. , Sun M.-F. , Whitlock J.A. , Gailani D.
      Blood92:3309-3317(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ASN-266;VARIANT ARG-244
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    21. 21.
      "Identification of a novel mutation in a non-Jewish factor XI deficient kindred."
      Alhaq A. , Mitchell M. , Sethi M. , Rahman S. , Flynn G. , Boulton P. , Caeno G. , Smith M. , Savidge G.
      Br. J. Haematol.104:44-49(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D CYS-246
    22. 22.
      "Heterozygous factor XI deficiency associated with three novel mutations."
      Mitchell M. , Cutler J. , Thompson S. , Moore G. , Jenkins Ap Rees E. , Smith M. , Savidge G. , Alhaq A.
      Br. J. Haematol.107:763-765(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D CYS-326; VAL-430 ILE-493 AND ARG-594
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-66; ARG-244; PHE-308 AND PHE-339
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    25. 25.
      "Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene."
      Zivelin A. , Bauduer F. , Ducout L. , Peretz H. , Rosenberg N. , Yatuv R. , Seligsohn U.
      Blood99:2448-2454(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ARG-56; TYR-255 AND HIS-511;VARIANT PHE-339;CHARACTERIZATION OF VARIANTS FA11D ARG-56; TYR-255 AND HIS-511
    26. 26.
      "Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain."
      Kravtsov D.V. , Wu W. , Meijers J.C.M. , Sun M.-F. , Blinder M.A. , Dang T.P. , Wang H. , Gailani D.
      Blood104:128-134(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D VAL-418 AND SER-587;CHARACTERIZATION OF VARIANTS FA11D VAL-418 AND SER-587
    27. 27.
      "Severe factor XI deficiency caused by compound heterozygosity."
      Dai L. , Mitchell M. , Carson P. , Creagh D. , Cutler J. , Savidge G. , Alhaq A.
      Br. J. Haematol.125:817-818(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D ILE-270;CHARACTERIZATION OF VARIANT F11 DEFICIENCY ILE-270
    28. 28.
      "Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion."
      Hill M. , McLeod F. , Franks H. , Gordon B. , Dolan G.
      Br. J. Haematol.129:825-829(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D PHE-46; ARG-101; CYS-151; GLU-263; VAL-430; LEU-538; LYS-565 AND SER-618
    29. 29.
      "Identification of five novel mutations in the factor XI gene (F11) of patients with factor XI deficiency."
      Quelin F. , Mathonnet F. , Potentini-Esnault C. , Trigui N. , Peynet J. , Bastenaire B. , Guillon L. , Bigel M.L. , Sauger A. , Mazurier C. , de Mazancourt P.
      Blood Coagul. Fibrinolysis17:69-73(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D TYR-140; LYS-315 AND LYS-597
    30. 30.
      "Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients."
      Fard-Esfahani P. , Lari G.R. , Ravanbod S. , Mirkhani F. , Allahyari M. , Rassoulzadegan M. , Ala F.
      Haemophilia14:91-95(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ILE-51; PRO-51; ILE-331; PRO-360; PRO-503 AND HIS-608
    31. 31.
      "Population-specific spectrum of the F11 mutations in Koreans: evidence for a founder effect."
      Kim J. , Song J. , Lyu C. , Kim Y. , Oh S. , Choi Y. , Yoo J. , Choi J. , Kim H. , Lee K.A.
      Clin. Genet.82:180-186(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D ARG-32; GLN-53; THR-252; ARG-401 AND GLU-526
    32. 32.
      "Three dominant-negative mutations in factor XI-deficient patients."
      Dai L. , Rangarajan S. , Mitchell M.
      Haemophilia17:E919-E922(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D THR-43; LEU-241 AND MET-403;CHARACTERIZATION OF VARIANTS FA11D THR-43; LEU-241 AND MET-403
    33. 33.
      "A novel missense mutation Asp506Gly in exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency."
      Lee J.H. , Cho H.S. , Hyun M.S. , Kim H.Y. , Kim H.J.
      Korean J. Lab. Med.31:290-293(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D GLY-506
    34. 34.
      "Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency."
      Tirefort Y. , Uhr M.R. , Neerman-Arbez M. , de Moerloose P.
      Blood Coagul. Fibrinolysis23:251-252(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D SER-481
    35. 35.
      "A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy."
      Girolami A. , Scarparo P. , Bonamigo E. , Santarossa L. , Cristiani A. , Moro S. , Lombardi A.M.
      Eur. J. Haematol.88:229-236(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA11D LYS-454
    36. 36.
      "Revisiting the molecular epidemiology of factor XI deficiency: nine new mutations and an original large 4qTer deletion in western Brittany (France)."
      Gueguen P. , Chauvin A. , Quemener-Redon S. , Pan-Petesch B. , Ferec C. , Abgrall J.F. , Le Marechal C.
      Thromb. Haemost.107:44-50(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA11D PRO-51; ARG-56; VAL-63; TYR-222; GLN-228; CYS-276; ASP-277; PHE-514; LEU-575 AND LYS-597
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