Protein name:
Coagulation factor XII ;
Alternative:
Hageman factor (HAF) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.
Function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRALLLLGFL | LVSLESTLSI | PPWEAPKEHK | YKAEEHTVVL | TVTGEPCHFP |
100:
FQYHRQLYHK | CTHKGRPGPQ | PWCATTPNFD | QDQRWGYCLE | PKKVKDHCSK |
150:
HSPCQKGGTC | VNMPSGPHCL | CPQHLTGNHC | QKEKCFEPQL | LRFFHKNEIW |
200:
YRTEQAAVAR | CQCKGPDAHC | QRLASQACRT | NPCLHGGRCL | EVEGHRLCHC |
250:
PVGYTGAFCD | VDTKASCYDG | RGLSYRGLAR | TTLSGAPCQP | WASEATYRNV |
300:
TAEQARNWGL | GGHAFCRNPD | NDIRPWCFVL | NRDRLSWEYC | DLAQCQTPTQ |
350:
AAPPTPVSPR | LHVPLMPAQP | APPKPQPTTR | TPPQSQTPGA | LPAKREQPPS |
400:
LTRNGPLSCG | QRLRKSLSSM | TRVVGGLVAL | RGAHPYIAAL | YWGHSFCAGS |
450:
LIAPCWVLTA | AHCLQDRPAP | EDLTVVLGQE | RRNHSCEPCQ | TLAVRSYRLH |
500:
EAFSPVSYQH | DLALLRLQED | ADGSCALLSP | YVQPVCLPSG | AARPSETTLC |
550:
QVAGWGHQFE | GAEEYASFLQ | EAQVPFLSLE | RCSAPDVHGS | SILPGMLCAG |
600:
FLEGGTDACQ | GDSGGPLVCE | DQAAERRLTL | QGIISWGSGC | GDRNKPGVYT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Bovine
Rat
Mouse
ELISA Kit for Human Coagulation factor XII
ELISA Kit for Human Coagulation factor XII
ELISA Kit for Human Coagulation factor XII
ELISA Kit for Human Coagulation factor XII
ELISA Kit for Human Coagulation factor XII
CLIA Kit for Human Coagulation factor XII
CLIA Kit for Human Coagulation factor XII
CLIA Kit for Human Coagulation factor XII
CLIA Kit for Human Coagulation factor XII
CLIA Kit for Human Coagulation factor XII
Polyclonal Antibody for Human Coagulation factor XII
Polyclonal Antibody for Human Coagulation factor XII
Polyclonal Antibody for Human Coagulation factor XII
Polyclonal Antibody for Human Coagulation factor XII
Polyclonal Antibody for Human Coagulation factor XII
Monoclonal Antibody for Human Coagulation factor XII
Monoclonal Antibody for Human Coagulation factor XII
Monoclonal Antibody for Human Coagulation factor XII
Monoclonal Antibody for Human Coagulation factor XII
Monoclonal Antibody for Human Coagulation factor XII
Protein for Human Coagulation factor XII
Protein for Human Coagulation factor XII
Protein for Human Coagulation factor XII
Protein for Human Coagulation factor XII
Protein for Human Coagulation factor XII
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT HAE3 LYS-328