F12 ELISA Kit for Human(Homo sapiens) | EIAab.comF12 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > F12(Gene name) > Human

F12 (Gene name),

Coagulation factor XII (Protein name ), FA12_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

F12;

Protein name:

Coagulation factor XII;

Alternative:

Hageman factor(HAF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.

Function:

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

615

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

615:

DVAYYLAWIR | EHTVS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

P00748

MIM:

234000

Pfam:

PF00008

UniGene:

Hs.1321

STRING:

9606.ENSP00000253496

String:

P00748

KEGG:

hsa:2161

Uniprot:

P00748

FOR

ELISA Kit for Human Coagulation factor XII

Cat.:

E0694h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Coagulation factor XII

Cat.:

E0694p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Coagulation factor XII

Cat.:

E0694b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Coagulation factor XII

Cat.:

E0694r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Coagulation factor XII

Cat.:

E0694m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Coagulation factor XII

Cat.:

U0694b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Coagulation factor XII

Cat.:

U0694r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Coagulation factor XII

Cat.:

U0694m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Coagulation factor XII

Cat.:

U0694h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Coagulation factor XII

Cat.:

U0694p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Coagulation factor XII

Cat.:

P0694Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor XII

Cat.:

P0694Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor XII

Cat.:

P0694Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor XII

Monoclonal Antibody for Human Coagulation factor XII

Protein for Human Coagulation factor XII

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region."
Cool D.E. , McGillivray R.T.A.
J. Biol. Chem.262:13662-13673(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-207
2.

SeattleSNPs variation discovery resource
Submitted (2002-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-207; ASP-545 AND HIS-605
3.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"cDNA sequence coding for human coagulation factor XII (Hageman)."
Tripodi M. , Citarella F. , Guida S. , Galeffi P. , Fantoni A. , Cortese R.
Nucleic Acids Res.14:3146-3146(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-615;VARIANT PRO-207
5.

"Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa."
Cool D.E. , Edgell C.-J.S. , Louie G.V. , Zoller M.J. , Brayer G.D. , McGillivray R.T.A.
J. Biol. Chem.260:13666-13676(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-615;VARIANT PRO-207
6.

"Characterization of a cDNA coding for human factor XII (Hageman factor)."
Que B.G. , Davie E.W.
Biochemistry25:1525-1528(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 146-615;VARIANT PRO-207
7.

"Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor)."
McMullen B.A. , Fujikawa K.
J. Biol. Chem.260:5328-5341(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-379;GLYCOSYLATION AT ASN-249; THR-299; THR-305; SER-308; THR-328; THR-329 AND THR-337;VARIANT PRO-207
8.

"Amino acid sequence of human beta-factor XIIa."
Fujikawa K. , McMullen B.A.
J. Biol. Chem.258:10924-10933(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 354-362 AND 373-615
9.

"The novel acceptor splice site mutation 11396(G-->A) in the factor XII gene causes a truncated transcript in cross-reacting material negative patients."
Schloesser M. , Hofferbert S. , Bartz U. , Lutze G. , Lammle B. , Engel W.
Hum. Mol. Genet.4:1235-1237(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 561-615;VARIANT FA12D ARG-589
tissue: Blood.
10.

"O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C."
Harris R.J. , Ling V.T. , Spellman M.W.
J. Biol. Chem.267:5102-5107(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-109
11.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-433
tissue: Plasma.
12.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-249 AND ASN-433
tissue: Plasma.
13.

"Factor XII gene alteration in Hageman trait detected by TaqI restriction enzyme."
Bernardi F. , Marchetti G. , Patracchini P. , del Senno L. , Tripodi M. , Fantoni A. , Bartolai S. , Vannini F. , Felloni L. , Rossi L. , Panicucci F. , Conconi F.
Blood69:1421-1424(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN FA12D
14.

"Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation."
Macquarrie J.L. , Stafford A.R. , Yau J.W. , Leslie B.A. , Vu T.T. , Fredenburgh J.C. , Weitz J.I.
Blood117:4134-4141(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRG;FUNCTION
15.

"The structure of the FnI-EGF-like tandem domain of coagulation factor XII solved using SIRAS."
Beringer D.X. , Kroon-Batenburg L.M.
Acta Crystallogr. F69:94-102(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 133-213;DISULFIDE BONDS
16.

"Coagulation factor XII (Hageman factor) Washington D.C.: inactive factor XIIa results from Cys-571-->Ser substitution."
Miyata T. , Kawabata S. , Iwanaga S. , Takahashi I. , Alving B. , Saito H.
Proc. Natl. Acad. Sci. U.S.A.86:8319-8322(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA12D SER-590
17.

"Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg-353-->Pro leading to loss of a kallikrein cleavage site."
Hovinga J.K. , Schaller J. , Stricker H. , Wuillemin W.A. , Furlan M. , Laemmle B.
Blood84:1173-1181(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA12D PRO-372
18.

"Mutations in the human factor XII gene."
Schloesser M. , Zeerleder S. , Lutze G. , Halbmayer W.-M. , Hofferbert S. , Hinney B. , Koestering H. , Laemmle B. , Pindur G. , Thies K. , Koehler M. , Engel W.
Blood90:3967-3977(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA12D MET-414; GLN-417; ASN-461 AND ARG-589
19.

"Factor XII Tenri, a novel cross-reacting material negative factor XII deficiency, occurs through a proteasome-mediated degradation."
Kondo S. , Tokunaga F. , Kawano S. , Oono Y. , Kumagai S. , Koide T.
Blood93:4300-4308(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA12D CYS-53
20.

"Identification and characterization of two novel mutations (Q421K and R123P) in congenital factor XII deficiency."
Kanaji T. , Kanaji S. , Osaki K. , Kuroiwa M. , Sakaguchi M. , Mihara K. , Niho Y. , Okamura T.
Thromb. Haemost.86:1409-1415(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FA12D PRO-142 AND LYS-440;CHARACTERIZATION OF VARIANTS FA12D PRO-142 AND LYS-440
21.

"Genetic analyses and expression studies identified a novel mutation (W486C) as a molecular basis of congenital coagulation factor XII deficiency."
Ishii K. , Oguchi S. , Moriki T. , Yatabe Y. , Takeshita E. , Murata M. , Ikeda Y. , Watanabe K.
Blood Coagul. Fibrinolysis15:367-373(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA12D CYS-505;CHARACTERIZATION OF VARIANT FA12D CYS-505
22.

"Factor XII Shizuoka, a novel mutation (Ala392Thr) identified and characterized in a patient with congenital coagulation factor XII deficiency."
Oguchi S. , Ishii K. , Moriki T. , Takeshita E. , Murata M. , Ikeda Y. , Watanabe K.
Thromb. Res.115:191-197(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA12D THR-411;CHARACTERIZATION OF VARIANT FA12D THR-411
23.

"Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor."
Dewald G. , Bork K.
Biochem. Biophys. Res. Commun.343:1286-1289(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HAE3 LYS-328 AND ARG-328
24.

"Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III."
Cichon S. , Martin L. , Hennies H.C. , Mueller F. , Van Driessche K. , Karpushova A. , Stevens W. , Colombo R. , Renne T. , Drouet C. , Bork K. , Noethen M.M.
Am. J. Hum. Genet.79:1098-1104(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HAE3 LYS-328

Product Feedback Wall

* Email:
*Comments: