Protein name:
Coagulation factor V ;
Alternative:
Proaccelerin, labile factor ;Activated protein C cofactor ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent.
Function:
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Subcellular Location:
Secreted
Protein Attributes:
50:
MFPGCPRLWV | LVVLGTSWVG | WGSQGTEAAQ | LRQFYVAAQG | ISWSYRPEPT |
100:
NSSLNLSVTS | FKKIVYREYE | PYFKKEKPQS | TISGLLGPTL | YAEVGDIIKV |
150:
HFKNKADKPL | SIHPQGIRYS | KLSEGASYLD | HTFPAEKMDD | AVAPGREYTY |
200:
EWSISEDSGP | THDDPPCLTH | IYYSHENLIE | DFNSGLIGPL | LICKKGTLTE |
250:
GGTQKTFDKQ | IVLLFAVFDE | SKSWSQSSSL | MYTVNGYVNG | TMPDITVCAH |
300:
DHISWHLLGM | SSGPELFSIH | FNGQVLEQNH | HKVSAITLVS | ATSTTANMTV |
350:
GPEGKWIISS | LTPKHLQAGM | QAYIDIKNCP | KKTRNLKKIT | REQRRHMKRW |
400:
EYFIAAEEVI | WDYAPVIPAN | MDKKYRSQHL | DNFSNQIGKH | YKKVMYTQYE |
450:
DESFTKHTVN | PNMKEDGILG | PIIRAQVRDT | LKIVFKNMAS | RPYSIYPHGV |
500:
TFSPYEDEVN | SSFTSGRNNT | MIRAVQPGET | YTYKWNILEF | DEPTENDAQC |
550:
LTRPYYSDVD | IMRDIASGLI | GLLLICKSRS | LDRRGIQRAA | DIEQQAVFAV |
600:
FDENKSWYLE | DNINKFCENP | DEVKRDDPKF | YESNIMSTIN | GYVPESITTL |
650:
GFCFDDTVQW | HFCSVGTQNE | ILTIHFTGHS | FIYGKRHEDT | LTLFPMRGES |
700:
VTVTMDNVGT | WMLTSMNSSP | RSKKLRLKFR | DVKCIPDDDE | DSYEIFEPPE |
750:
STVMATRKMH | DRLEPEDEES | DADYDYQNRL | AAALGIRSFR | NSSLNQEEEE |
800:
FNLTALALEN | GTEFVSSNTD | IIVGSNYSSP | SNISKFTVNN | LAEPQKAPSH |
850:
QQATTAGSPL | RHLIGKNSVL | NSSTAEHSSP | YSEDPIEDPL | QPDVTGIRLL |
900:
SLGAGEFKSQ | EHAKHKGPKV | ERDQAAKHRF | SWMKLLAHKV | GRHLSQDTGS |
950:
PSGMRPWEDL | PSQDTGSPSR | MRPWKDPPSD | LLLLKQSNSS | KILVGRWHLA |
1000:
SEKGSYEIIQ | DTDEDTAVNN | WLISPQNASR | AWGESTPLAN | KPGKQSGHPK |
1050:
FPRVRHKSLQ | VRQDGGKSRL | KKSQFLIKTR | KKKKEKHTHH | APLSPRTFHP |
1100:
LRSEAYNTFS | ERRLKHSLVL | HKSNETSLPT | DLNQTLPSMD | FGWIASLPDH |
1150:
NQNSSNDTGQ | ASCPPGLYQT | VPPEEHYQTF | PIQDPDQMHS | TSDPSHRSSS |
1200:
PELSEMLEYD | RSHKSFPTDI | SQMSPSSEHE | VWQTVISPDL | SQVTLSPELS |
1250:
QTNLSPDLSH | TTLSPELIQR | NLSPALGQMP | ISPDLSHTTL | SPDLSHTTLS |
1300:
LDLSQTNLSP | ELSQTNLSPA | LGQMPLSPDL | SHTTLSLDFS | QTNLSPELSH |
1350:
MTLSPELSQT | NLSPALGQMP | ISPDLSHTTL | SLDFSQTNLS | PELSQTNLSP |
1400:
ALGQMPLSPD | PSHTTLSLDL | SQTNLSPELS | QTNLSPDLSE | MPLFADLSQI |
1450:
PLTPDLDQMT | LSPDLGETDL | SPNFGQMSLS | PDLSQVTLSP | DISDTTLLPD |
1500:
LSQISPPPDL | DQIFYPSESS | QSLLLQEFNE | SFPYPDLGQM | PSPSSPTLND |
1550:
TFLSKEFNPL | VIVGLSKDGT | DYIEIIPKEE | VQSSEDDYAE | IDYVPYDDPY |
1600:
KTDVRTNINS | SRDPDNIAAW | YLRSNNGNRR | NYYIAAEEIS | WDYSEFVQRE |
1650:
TDIEDSDDIP | EDTTYKKVVF | RKYLDSTFTK | RDPRGEYEEH | LGILGPIIRA |
1700:
EVDDVIQVRF | KNLASRPYSL | HAHGLSYEKS | SEGKTYEDDS | PEWFKEDNAV |
1750:
QPNSSYTYVW | HATERSGPES | PGSACRAWAY | YSAVNPEKDI | HSGLIGPLLI |
1800:
CQKGILHKDS | NMPMDMREFV | LLFMTFDEKK | SWYYEKKSRS | SWRLTSSEMK |
1850:
KSHEFHAING | MIYSLPGLKM | YEQEWVRLHL | LNIGGSQDIH | VVHFHGQTLL |
1900:
ENGNKQHQLG | VWPLLPGSFK | TLEMKASKPG | WWLLNTEVGE | NQRAGMQTPF |
1950:
LIMDRDCRMP | MGLSTGIISD | SQIKASEFLG | YWEPRLARLN | NGGSYNAWSV |
2000:
EKLAAEFASK | PWIQVDMQKE | VIITGIQTQG | AKHYLKSCYT | TEFYVAYSSN |
2050:
QINWQIFKGN | STRNVMYFNG | NSDASTIKEN | QFDPPIVARY | IRISPTRAYN |
2100:
RPTLRLELQG | CEVNGCSTPL | GMENGKIENK | QITASSFKKS | WWGDYWEPFR |
2150:
ARLNAQGRVN | AWQAKANNNK | QWLEIDLLKI | KKITAIITQG | CKSLSSEMYV |
2200:
KSYTIHYSEQ | GVEWKPYRLK | SSMVDKIFEG | NTNTKGHVKN | FFNPPIISRF |
2224:
IRVIPKTWNQ | SIALRLELFG | CDIY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Bovine
Mouse
ELISA Kit for Human Coagulation factor V
ELISA Kit for Human Coagulation factor V
ELISA Kit for Human Coagulation factor V
ELISA Kit for Human Coagulation factor V
CLIA Kit for Human Coagulation factor V
CLIA Kit for Human Coagulation factor V
CLIA Kit for Human Coagulation factor V
CLIA Kit for Human Coagulation factor V
Polyclonal Antibody for Human Coagulation factor V
Polyclonal Antibody for Human Coagulation factor V
Polyclonal Antibody for Human Coagulation factor V
Polyclonal Antibody for Human Coagulation factor V
Monoclonal Antibody for Human Coagulation factor V
Monoclonal Antibody for Human Coagulation factor V
Monoclonal Antibody for Human Coagulation factor V
Monoclonal Antibody for Human Coagulation factor V
Protein for Human Coagulation factor V
Protein for Human Coagulation factor V
Protein for Human Coagulation factor V
Protein for Human Coagulation factor V
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEIDEN GLN-534
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1030;VARIANT LYS-513
tissue :
Placenta .
6.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-1600;VARIANTS ARG-858; ARG-865; GLU-925 AND ILE-1285
7.
"Human coagulation factor V, exon 13, missense mutation Asn713Ser."
Kostka H.
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 658-1598
8.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 660-1598;VARIANTS ARG-858; ARG-865; GLU-925 AND PHE-1397
9.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1188-1215 AND 1315-2224
10.
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Cited for : PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Fibroblast .
11.
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
12.
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Cited for : COPPER-BINDING
13.
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
14.
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Cited for : SULFATION
15.
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Cited for : SULFATION
16.
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Cited for : CLEAVAGE AT ARG-334; ARG-534; ARG-707 AND LYS-1022 BY ACTIVATED PROTEIN C
17.
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Cited for : HETERODIMER WITH SERPINA5
18.
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
19.
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Cited for : INVOLVEMENT IN RPRGL1 SUSCEPTIBILITY
20.
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
21.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-297; ASN-460; ASN-821; ASN-977 AND ASN-1559
tissue :
Plasma .
22.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-297
tissue :
Platelet .
23.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
24.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-640;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
25.
"Crystal structures of the membrane-binding C2 domain of human coagulation factor V."
Macedo-Ribeiro S.
,
Bode W.
,
Huber R.
,
Quinn-Allen M.A.
,
Kim S.W.
,
Ortel T.L.
,
Bourenkov G.P.
,
Bartunik H.D.
,
Stubbs M.T.
,
Kane W.H.
,
Fuentes-Prior P.
Nature402:434-439(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2065-2224
26.
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Cited for : VARIANT VAL-1764
27.
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Cited for : VARIANT LEIDEN GLN-534
28.
"Detection of new polymorphic markers in the factor V gene: association with factor V levels in plasma."
Lunghi B.
,
Iacoviello L.
,
Gemmati D.
,
Dilasio M.G.
,
Castoldi E.
,
Pinotti M.
,
Castaman G.
,
Redaelli R.
,
Mariani G.
,
Marchetti G.
,
Bernardi F.
Thromb. Haemost.75:45-48(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS ILE-1285 AND ARG-1327
29.
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Cited for : ASSOCIATION OF VARIANT LEIDEN GLN-534 WITH SUSCEPTIBILITY TO BUDD-CHIARI SYNDROME
30.
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Cited for : VARIANT HONG KONG GLY-334;VARIANT LYS-513
31.
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Cited for : VARIANT THPH2 THR-334
32.
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Cited for : VARIANT HONG KONG GLY-334
33.
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.22:231-238(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LEIDEN GLN-534;VARIANTS HIS-107; THR-413; LYS-513; SER-809; THR-817; ARG-858; ARG-865; GLU-925; GLN-1146; ALA-1530; SER-1685; VAL-1749; VAL-1764; ILE-1820 AND GLY-2222
34.
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.23:373-373(1999)
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Cited for : ERRATUM
35.
"Combinations of 4 mutations (FV R506Q, FV H1299R, FV Y1702C, PT 20210G/A) affecting the prothrombinase complex in a thrombophilic family."
Castoldi E.
,
Simioni P.
,
Kalafatis M.
,
Lunghi B.
,
Tormene D.
,
Girelli D.
,
Girolami A.
,
Bernardi F.
Blood96:1443-1448(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FA5D CYS-1730;VARIANT LEIDEN GLN-534;VARIANT ARG-1327
36.
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Cited for : VARIANTS THPH2 ARG-613 AND CYS-1730
37.
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Cited for : VARIANT THPH2 HIS-2102
38.
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Cited for : VARIANT FA5D CYS-2102;CHARACTERIZATION OF VARIANT FA5D CYS-2102
39.
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Cited for : VARIANT THPH2 THR-387
40.
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Cited for : ASSOCIATION OF VARIANT GLN-534 WITH SUSCEPTIBILITY TO ISCHSTR
41.
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Cited for : CHARACTERIZATION OF VARIANT THPH2 THR-387
42.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] ALA-775