Gene name:
Fam21 (D6Wsu116e;Kiaa0592) ;
Protein name:
WASH complex subunit FAM21 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53 (By similarity). Interacts (via WHD1 region) with WASH1; the interaction is direct.
Function:
Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes.
Subcellular Location:
Early endosome membrane
Protein Attributes:
50:
MNRTSPDSER | PPASEPVWER | PWSVEEIRRS | SQNWSLAADA | GLLQFLQEFS |
100:
QQTISRTHEI | KKQVDGLIQE | TKATHCRLHN | VFNDFLMLSN | TQFIENRVYD |
150:
EEVEEQVLKA | EAEKAEQEKT | REQKEIDLIP | KVQEAVNYGL | QVLDSAFEQL |
200:
DIKAGNSDSE | EDDANERVDL | ILEPKDLYID | RPLPYLIGSK | LFMEQEDVGL |
250:
GELSSEEGSV | GSDRGSIVDS | EDEKEEEESD | EDFASHSDND | QNQHTTQISD |
300:
EEEDDDGDLF | ADSEKEGDDI | EDIEESAKSK | RPTSFADELA | ARIKGDISNQ |
350:
RKEGQTDGKP | QKTVKEKKER | RTPADDEEDI | LFPPPTLTDE | DFSPFGSRGG |
400:
LFSNGQGLFD | DEDESDLFKE | APRARPAQAP | VSEELPPSPK | PGKKIPAGAV |
450:
SVLLGHPDVS | GSTSAPSLKE | LQKHGQPTPG | KSSHLPTPAG | LFDDDDNDND |
500:
EDDNNFFMPS | SSKPSKTDKV | KSTAIIFDDD | EGDLFKEKAE | ALPAASVSQT |
550:
HESKTRADKT | IALPSSKNLK | LVSETKTQKG | LFSDEEDSED | LFSSQSSSKP |
600:
KSASLPSSQP | PTSVSLFGDE | DEEDSLFGSA | AAKKQTSSLQ | PQSQEKAKPS |
650:
EQPSKKTSAL | LFSSDEEDQW | NIADSHTKLA | SDNKSKGELW | DSGATQGQEA |
700:
KAVKKTNLFE | DDDDDEVDLF | AIAKDSQKKT | QRTSLLFEDD | AESGSSLFGL |
750:
PPTSVPSATT | KKESVPKVPL | LFSDEEDSEV | PSGVKPEDLK | VDNARVSPEV |
800:
GSADVASIAQ | KEGLLPASDQ | EAGGPSDIFS | SSSPLDKGAK | GRTRTVLSLF |
850:
DEDEDKVEDE | SSTCAPQDGR | EKGLKTDSRP | KSTGVFQDEE | LLFSHKLQKD |
900:
NDPDVDLFAG | TKKIRSSVPS | GGSLFGDDED | DDLFSSAKTQ | PVVPEKKGTL |
950:
KKDHPVSLKN | QDPLDSTQGS | KEKSTWKTEP | AQDSSGLTPF | KSREPSSRIG |
1000:
KIQANLAINP | AALLPTVALQ | IPGTKPVSSE | LAFPSSEPGR | SHILESVPTL |
1050:
PGSVEAGVSF | DLPAQADTLH | SANKSRVKVR | GKRRPQTRAA | RRLAAQESSE |
1100:
AEDVTVDRGP | VAQLSSSPVL | PNGHQPLLQP | RMASGQTSSE | TATAPPWEGG |
1150:
PVLSAADRSF | FVKSRPQTGN | EADLFDSGDI | FPKSRGSQSV | EGAGVMAGEP |
1200:
PSHSSGGRKE | KSLAFPDLSE | GSSTEDLFQS | VKPRAAKNRN | PFPLLEDEED |
1250:
LFADPRGKKN | ERKPDSHQDS | VSKTHDIFED | DIFATEAIKP | FPKKREKGRT |
1300:
LEPNLFDDNI | DIFADLTVKP | KEKSKKKVAA | KSMFDDDTDD | IFSSGLQAKA |
1334:
SKPKSQSAEA | ASEQRSEHKV | ASIFDDPLNA | FGSQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
ELISA Kit for Mouse WASH complex subunit FAM21
ELISA Kit for Mouse WASH complex subunit FAM21
CLIA Kit for Mouse WASH complex subunit FAM21
CLIA Kit for Mouse WASH complex subunit FAM21
Polyclonal Antibody for Mouse WASH complex subunit FAM21
Polyclonal Antibody for Mouse WASH complex subunit FAM21
Monoclonal Antibody for Mouse WASH complex subunit FAM21
Monoclonal Antibody for Mouse WASH complex subunit FAM21
Protein for Mouse WASH complex subunit FAM21
Protein for Mouse WASH complex subunit FAM21
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Head .
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
strain :
FVB/N-3 .
tissue :
Brain .
tissue :
Mammary tumor .
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Mol. Cell. Proteomics6:283-293(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain cortex .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-747;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-159; SER-284; SER-388; SER-533; SER-613; SER-614; SER-723; SER-747; SER-1169; SER-1172; SER-1173 AND SER-1333;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614 AND SER-747;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .