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Index > Protein center > Fancl(Gene name) > Mouse
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  • Fancl (Gene name),
  • E3 ubiquitin-protein ligase FANCL (Protein name ),  FANCL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Fancl(Phf9;Pog);
    Protein name:
    E3 ubiquitin-protein ligase FANCL;
    Alternative:
    Proliferation of germ cells protein;Fanconi anemia group L protein homolog;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity). In complex with FANCF, FANCA and FANCG, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins (By similarity). Interacts with GGN.
    Function:
    Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway (By similarity). Probably essential for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MDEAEASLLR | HFPLLLPQNR | EKTVYEGFIS | AQGSDFHLRI | VLPKDLQLKK | 
    100:
    ARLLCSLQLK | NILNEYHQVV | QQRMKHSPDL | MSFMMELKMI | LEVALKNKQE | 
    150:
    LCVQPPSCSF | CKDLLTEIGA | IGWDKLACVE | SSFSTIKLKA | DDASGRKHLI | 
    200:
    TVKLKAKYPV | EPPDCVVDFP | VPFSVSWTPQ | SSLVDVYSQF | LVALETLKVF | 
    250:
    WDVMDEIDEK | TWVLEPEKPP | RSATARRIAL | GKNVSIAIEV | DPRHPTMLPE | 
    300:
    FCFLGADHVT | KPLGMKLSGS | IHLWDPENSL | LQNLKDVLEI | DFPARSILEE | 
    350:
    SDFSMDCGIC | YARHLNGAIP | DQVCNNPQCG | QPFHEICLYE | WLRGLSTSRQ | 
    375:
    SFNVFFGDCP | YCSKPITLKM | SGRKP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase FANCL
    ELISA Kit for Mouse E3 ubiquitin-protein ligase FANCL
    CLIA Kit for Mouse E3 ubiquitin-protein ligase FANCL
    CLIA Kit for Mouse E3 ubiquitin-protein ligase FANCL
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
    Protein for Mouse E3 ubiquitin-protein ligase FANCL
    Protein for Mouse E3 ubiquitin-protein ligase FANCL

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd."
      Agoulnik A.I. , Lu B. , Zhu Q. , Truong C. , Ty M.T. , Arango N. , Chada K.K. , Bishop C.E.
      Hum. Mol. Genet.11:3047-3053(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
      strain: C57BL/6.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Kidney.
      tissue: Small intestine.
      tissue: Thymus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Pancreas.
      tissue: Thymus.
    4. 4.
      "Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia."
      Lu B. , Bishop C.E.
      Biol. Reprod.69:161-168(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis."
      Lu B. , Bishop C.E.
      J. Biol. Chem.278:16289-16296(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GGN
    6. 6.
      "UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2."
      Zhang Y. , Zhou X. , Zhao L. , Li C. , Zhu H. , Xu L. , Shan L. , Liao X. , Guo Z. , Huang P.
      Mol. Cells31:113-122(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2W;SUBCELLULAR LOCATION
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