Gene name:
Fancl (Phf9;Pog) ;
Protein name:
E3 ubiquitin-protein ligase FANCL ;
Alternative:
Proliferation of germ cells protein ;Fanconi anemia group L protein homolog ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM (By similarity). In complex with FANCF, FANCA and FANCG, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins (By similarity). Interacts with GGN.
Function:
Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway (By similarity). Probably essential for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MDEAEASLLR | HFPLLLPQNR | EKTVYEGFIS | AQGSDFHLRI | VLPKDLQLKK |
100:
ARLLCSLQLK | NILNEYHQVV | QQRMKHSPDL | MSFMMELKMI | LEVALKNKQE |
150:
LCVQPPSCSF | CKDLLTEIGA | IGWDKLACVE | SSFSTIKLKA | DDASGRKHLI |
200:
TVKLKAKYPV | EPPDCVVDFP | VPFSVSWTPQ | SSLVDVYSQF | LVALETLKVF |
250:
WDVMDEIDEK | TWVLEPEKPP | RSATARRIAL | GKNVSIAIEV | DPRHPTMLPE |
300:
FCFLGADHVT | KPLGMKLSGS | IHLWDPENSL | LQNLKDVLEI | DFPARSILEE |
350:
SDFSMDCGIC | YARHLNGAIP | DQVCNNPQCG | QPFHEICLYE | WLRGLSTSRQ |
375:
SFNVFFGDCP | YCSKPITLKM | SGRKP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse E3 ubiquitin-protein ligase FANCL
ELISA Kit for Mouse E3 ubiquitin-protein ligase FANCL
CLIA Kit for Mouse E3 ubiquitin-protein ligase FANCL
CLIA Kit for Mouse E3 ubiquitin-protein ligase FANCL
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase FANCL
Protein for Mouse E3 ubiquitin-protein ligase FANCL
Protein for Mouse E3 ubiquitin-protein ligase FANCL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd."
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Lu B.
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Hum. Mol. Genet.11:3047-3053(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
strain :
C57BL/6 .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Kidney .
tissue :
Small intestine .
tissue :
Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Pancreas .
tissue :
Thymus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GGN
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBE2W;SUBCELLULAR LOCATION