FBN2 ELISA Kit for Human(Homo sapiens) | EIAab.comFBN2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FBN2(Gene name) > Human

FBN2 (Gene name),

Fibrillin-2 (Protein name ), FBN2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FBN2;

Protein name:

Fibrillin-2;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

2912

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2912:

EALRMRLQIQ | LY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P35556

MIM:

121050

Pfam:

PF07645

String:

P35556

Pfam:

PF12662

KEGG:

hsa:2201

STRING:

9606.ENSP00000262464

UniGene:

Hs.519294

Uniprot:

P35556

FOR

ELISA Kit for Human Fibrillin-2

Cat.:

E8805h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human Fibrillin-2

Cat.:

E8805m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Fibrillin-2

Cat.:

U8805h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Fibrillin-2

Cat.:

U8805m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Fibrillin-2

Cat.:

P8805Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Fibrillin-2

Cat.:

P8805Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Fibrillin-2

Protein for Human Fibrillin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices."
Zhang H. , Apfelroth S.D. , Hu W. , Davis E.C. , Sanguineti C. , Bonadio J. , Mecham R.P. , Ramirez F.
J. Cell Biol.124:855-863(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-594; GLY-1772; LEU-2266; LEU-2580 AND PRO-2771
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
3.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes."
Lee B. , Godfrey M. , Vitale E. , Hori H. , Mattei M.-G. , Sarfarazi M. , Tsipouras P. , Ramirez F. , Hollister D.W.
Nature352:330-334(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 752-2912 (ISOFORM 2)
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 937-2912 (ISOFORM 1)
tissue: Aortic endothelium.
6.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1112
tissue: Liver.
7.

"Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly."
Putnam E.A. , Zhang H. , Ramirez F. , Milewicz D.M.
Nat. Genet.11:456-458(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DA9 TYR-1253 AND SER-1434;VARIANT ILE-965
8.

"Clustering of FBN2 mutations in patients with congenital contractural arachnodactyly indicates an important role of the domains encoded by exons 24 through 34 during human development."
Park E.-S. , Putnam E.A. , Chitayat D. , Child A. , Milewicz D.M.
Am. J. Med. Genet.78:350-355(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DA9 ASP-1057 AND THR-1093;VARIANTS SER-594; HIS-681; ILE-965; GLY-1772; LEU-2266; THR-2428 AND PRO-2771
9.

"A single mutation that results in an Asp-to-His substitution and partial exon skipping in a family with congenital contractural arachnodactyly."
Babcock D. , Gasner C. , Francke U. , Maslen C.
Hum. Genet.103:22-28(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DA9 HIS-1115
10.

"Two novel fibrillin-2 mutations in congenital contractural arachnodactyly."
Belleh S. , Zhou G. , Wang M. , Der Kaloustian V.M. , Pagon R.A. , Godfrey M.
Am. J. Med. Genet.92:7-12(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DA9 PHE-1142 AND TRP-1253
11.

"Ten novel FBN2 mutations in congenital contractural arachnodactyly: delineation of the molecular pathogenesis and clinical phenotype."
Gupta P.A. , Putnam E.A. , Carmical S.G. , Kaitila I. , Steinmann B. , Child A. , Danesino C. , Metcalfe K. , Berry S.A. , Chen E. , Delorme C.V. , Thong M.-K. , Ades L.C. , Milewicz D.M.
Hum. Mutat.19:39-48(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DA9 ASP-1057; THR-1093; PHE-1142; CYS-1179; TYR-1198; ARG-1240; TRP-1253; TYR-1253; TRP-1257; ARG-1268 AND SER-1434;VARIANT ILE-965
12.

"Comprehensive clinical and molecular assessment of 32 probands with congenital contractural arachnodactyly: report of 14 novel mutations and review of the literature."
Callewaert B.L. , Loeys B.L. , Ficcadenti A. , Vermeer S. , Landgren M. , Kroes H.Y. , Yaron Y. , Pope M. , Foulds N. , Boute O. , Galan F. , Kingston H. , Van der Aa N. , Salcedo I. , Swinkels M.E. , Wallgren-Pettersson C. , Gabrielli O. , De Backer J. , more...
Hum. Mutat.30:334-341(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS DA9 SER-754; SER-1091; HIS-1115; PRO-1122; ARG-1142; CYS-1146; PHE-1156; LYS-1161; PHE-1246; PHE-1384; TYR-1384; ASN-1408 AND ARG-1425
13.

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I. , Tarpey P. , Raine K. , Huang D. , Ong C.K. , Stephens P. , Davies H. , Jones D. , Lin M.L. , Teague J. , Bignell G. , Butler A. , Cho J. , Dalgliesh G.L. , Galappaththige D. , Greenman C. , Hardy C. , Jia M. , more...
Nature469:539-542(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-2062

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