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Index > Protein center > FCN1(Gene name) > Human
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  • FCN1 (Gene name),
  • Ficolin-1 (Protein name ),  FCN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FCN1(FCNM);
    Protein name:
    Ficolin-1;
    Alternative:
    Ficolin-A;Collagen/fibrinogen domain-containing protein 1;M-ficolin;Ficolin-alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homopolymer. Interacts with elastin.
    Function:
    Involved in serum exerting lectin activity. Binds GlcNAc.
    Subcellular Location:
    Secreted Found on the monocyte surface.
    Protein Attributes:
    Sequence length:
    326
    Sequence:
    50:
    MELSGATMAR | GLAVLLVLFL | HIKNLPAQAA | DTCPEVKVVG | LEGSDKLTIL | 
    100:
    RGCPGLPGAP | GPKGEAGVIG | ERGERGLPGA | PGKAGPVGPK | GDRGEKGMRG | 
    150:
    EKGDAGQSQS | CATGPRNCKD | LLDRGYFLSG | WHTIYLPDCR | PLTVLCDMDT | 
    200:
    DGGGWTVFQR | RMDGSVDFYR | DWAAYKQGFG | SQLGEFWLGN | DNIHALTAQG | 
    250:
    SSELRVDLVD | FEGNHQFAKY | KSFKVADEAE | KYKLVLGAFV | GGSAGNSLTG | 
    300:
    HNNNFFSTKD | QDNDVSSSNC | AEKFQGAWWY | ADCHASNLNG | LYLMGPHESY | 
    326:
    ANGINWSAAK | GYKYSYKVSE | MKVRPA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ficolin-1
    Cat.:
    E1506h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Ficolin-1
    Cat.:
    E1506r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Ficolin-1
    Cat.:
    E1506p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Ficolin-1
    Cat.:
    E1506m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ficolin-1
    Cat.:
    U1506p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ficolin-1
    Cat.:
    U1506m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ficolin-1
    Cat.:
    U1506h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ficolin-1
    Cat.:
    U1506r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ficolin-1
    Polyclonal Antibody for Human Ficolin-1
    Cat.:
    P1506Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ficolin-1
    Cat.:
    P1506Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ficolin-1
    Cat.:
    P1506Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ficolin-1
    Monoclonal Antibody for Human Ficolin-1
    Monoclonal Antibody for Human Ficolin-1
    Monoclonal Antibody for Human Ficolin-1
    Protein for Human Ficolin-1
    Protein for Human Ficolin-1
    Protein for Human Ficolin-1
    Protein for Human Ficolin-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9."
      Lu J. , Tay P.N. , Kon O.L. , Reid K.B.
      Biochem. J.313:473-478(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Uterus.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    6. 6.
      "Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1."
      Harumiya S. , Takeda K. , Sugiura T. , Fukumoto Y. , Tachikawa H. , Miyazono K. , Fujimoto D. , Ichijo H.
      J. Biochem.120:745-751(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-326
      tissue: Uterus.
    7. 7.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-44
    8. 8.
      "Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."
      Zhang J. , Yang L. , Ang Z. , Yoong S.L. , Tran T.T. , Anand G.S. , Tan N.S. , Ho B. , Ding J.L.
      J. Immunol.185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CRP AND FFAR2
    9. 9.
      "Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain."
      Honore C. , Rorvig S. , Hummelshoj T. , Skjoedt M.O. , Borregaard N. , Garred P.
      J. Leukoc. Biol.88:145-158(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    10. 10.
      "Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain."
      Tanio M. , Kondo S. , Sugio S. , Kohno T.
      J. Biol. Chem.282:3889-3895(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 115-326;SUBUNIT;DISULFIDE BONDS;CALCIUM-BINDING SITES;PH-DEPENDENCY
    11. 11.
      "Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch."
      Garlatti V. , Martin L. , Gout E. , Reiser J.B. , Fujita T. , Arlaud G.J. , Thielens N.M. , Gaboriaud C.
      J. Biol. Chem.282:35814-35820(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 109-326 IN COMPLEX WITH CARBOHYDRATE;DISULFIDE BONDS;CALCIUM-BINDING SITES;PH-DEPENDENCY
    12. 12.
      "Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin."
      Gout E. , Garlatti V. , Smith D.F. , Lacroix M. , Dumestre-Perard C. , Lunardi T. , Martin L. , Cesbron J.Y. , Arlaud G.J. , Gaboriaud C. , Thielens N.M.
      J. Biol. Chem.285:6612-6622(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.21 ANGSTROMS) OF 110-326;DISULFIDE BONDS;FUNCTION;SUBUNIT;SUBSTRATE SPECIFICITY;CALCIUM-BINDING SITES;MUTAGENESIS OF GLY-250; ALA-285 AND TYR-300
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-175
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