Gene name:
Fem1b (F1aa;Kiaa0396) ;
Protein name:
Protein fem-1 homolog B (FEM1b) ;
Alternative:
Fem-1-like death receptor-binding protein alpha ;FEM1-beta ;mt-Fem ;Fem-1-like in apoptotic pathway protein alpha (F1A-alpha) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A (By similarity). Interacts with CHEK1.
Function:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Subcellular Location:
Cytoplasm
Nucleus
Associated with chromatin.
Protein Attributes:
50:
MEGLAGYVYK | AASEGKVLTL | AALLLNRSES | DIRYLLGYVS | QQGGQRSTPL |
100:
IIAARNGHAK | VVRLLLEHYR | VQTQQTGTVR | FDGYVIDGAT | ALWCAAGAGH |
150:
FEVVKLLVSH | GANVNHTTVT | NSTPLRAACF | DGRLDIVKYL | VENNANISIA |
200:
NKYDNTCLMI | AAYKGHTDVV | RYLLEQRADP | NAKAHCGATA | LHFAAEAGHI |
250:
DIVKELIKWR | AAIVVNGHGM | TPLKVAAESC | KADVVELLLS | HADCDRRSRI |
300:
EALELLGASF | ANDRENYDIM | KTYHYLYLAM | LERFQDGDNI | LEKEVLPPIH |
350:
AYGNRTECRN | PQELEAIRQD | RDALHMEGLI | VRERILGADN | IDVSHPIIYR |
400:
GAVYADNMEF | EQCIKLWLHA | LHLRQKGNRN | THKDLLRFAQ | VFSQMIHLNE |
450:
AVKAPDIECV | LRCSVLEIEQ | SMNRVKNISD | ADVHSAMDNY | ECNLYTFLYL |
500:
VCISTKTQCS | EEDQCRINKQ | IYNLIHLDPR | TREGFSLLHL | AVNSNTPVDD |
550:
FHTNDVCSFP | NALVTKLLLD | CGAEVNAVDN | EGNSALHIIV | QYNRPISDFL |
600:
TLHSIIISLV | EAGAHTDMTN | KQNKTPLDKS | TTGVSEILLK | TQMKMSLKCL |
627:
AARAVRANDI | NYQDQIPRTL | EEFVGFH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Chicken
ELISA Kit for Mouse FEM1b
ELISA Kit for Mouse FEM1b
ELISA Kit for Mouse FEM1b
ELISA Kit for Mouse FEM1b
Polyclonal Antibody for Mouse FEM1b
Polyclonal Antibody for Mouse FEM1b
Polyclonal Antibody for Mouse FEM1b
Polyclonal Antibody for Mouse FEM1b
Monoclonal Antibody for Mouse FEM1b
Monoclonal Antibody for Mouse FEM1b
Monoclonal Antibody for Mouse FEM1b
Monoclonal Antibody for Mouse FEM1b
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
CD-1 .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Testis .
4.
"The transcriptional landscape of the mammalian genome."
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Science309:1559-1563(2005)
[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Olfactory bulb .
tissue :
Retina .
tissue :
Testis .
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-627
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH PHTF1
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE