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Index > Protein center > Fem1b(Gene name) > Mouse
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  • Fem1b (Gene name),
  • Protein fem-1 homolog B (Protein name ),  FEM1B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fem1b(F1aa;Kiaa0396);
    Protein name:
    Protein fem-1 homolog B(FEM1b);
    Alternative:
    Fem-1-like death receptor-binding protein alpha;FEM1-beta;mt-Fem;Fem-1-like in apoptotic pathway protein alpha(F1A-alpha);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homooligomer. Component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 and FEM1B. Interacts with PPM1F and PHTF1. Interacts with the death domain of FAS/TNFRSF6 and TNFRSF1A (By similarity). Interacts with CHEK1.
    Function:
    Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
    Subcellular Location:
    Cytoplasm Nucleus Associated with chromatin.
    Protein Attributes:
    Sequence length:
    627
    Sequence:
    50:
    MEGLAGYVYK | AASEGKVLTL | AALLLNRSES | DIRYLLGYVS | QQGGQRSTPL | 
    100:
    IIAARNGHAK | VVRLLLEHYR | VQTQQTGTVR | FDGYVIDGAT | ALWCAAGAGH | 
    150:
    FEVVKLLVSH | GANVNHTTVT | NSTPLRAACF | DGRLDIVKYL | VENNANISIA | 
    200:
    NKYDNTCLMI | AAYKGHTDVV | RYLLEQRADP | NAKAHCGATA | LHFAAEAGHI | 
    250:
    DIVKELIKWR | AAIVVNGHGM | TPLKVAAESC | KADVVELLLS | HADCDRRSRI | 
    300:
    EALELLGASF | ANDRENYDIM | KTYHYLYLAM | LERFQDGDNI | LEKEVLPPIH | 
    350:
    AYGNRTECRN | PQELEAIRQD | RDALHMEGLI | VRERILGADN | IDVSHPIIYR | 
    400:
    GAVYADNMEF | EQCIKLWLHA | LHLRQKGNRN | THKDLLRFAQ | VFSQMIHLNE | 
    450:
    AVKAPDIECV | LRCSVLEIEQ | SMNRVKNISD | ADVHSAMDNY | ECNLYTFLYL | 
    500:
    VCISTKTQCS | EEDQCRINKQ | IYNLIHLDPR | TREGFSLLHL | AVNSNTPVDD | 
    550:
    FHTNDVCSFP | NALVTKLLLD | CGAEVNAVDN | EGNSALHIIV | QYNRPISDFL | 
    600:
    TLHSIIISLV | EAGAHTDMTN | KQNKTPLDKS | TTGVSEILLK | TQMKMSLKCL | 
    627:
    AARAVRANDI | NYQDQIPRTL | EEFVGFH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse FEM1b
    ELISA Kit for Mouse FEM1b
    ELISA Kit for Mouse FEM1b
    ELISA Kit for Mouse FEM1b
    CLIA Kit for Mouse FEM1b
    CLIA Kit for Mouse FEM1b
    CLIA Kit for Mouse FEM1b
    CLIA Kit for Mouse FEM1b
    Polyclonal Antibody for Mouse FEM1b
    Polyclonal Antibody for Mouse FEM1b
    Polyclonal Antibody for Mouse FEM1b
    Polyclonal Antibody for Mouse FEM1b
    Monoclonal Antibody for Mouse FEM1b
    Monoclonal Antibody for Mouse FEM1b
    Monoclonal Antibody for Mouse FEM1b
    Monoclonal Antibody for Mouse FEM1b
    Protein for Mouse FEM1b
    Protein for Mouse FEM1b
    Protein for Mouse FEM1b
    Protein for Mouse FEM1b

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    References
    1. 1.
      "The murine fem1 gene family: homologs of the Caenorhabditis elegans sex-determination protein FEM-1."
      Ventura-Holman T. , Seldin M.F. , Li W. , Maher J.F.
      Genomics54:221-230(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      strain: CD-1.
      tissue: Testis.
    2. 2.
      "F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis."
      Chan S.-L. , Tan K.-O. , Zhang L. , Yee K.S.Y. , Ronca F. , Chan M.-Y. , Yu V.C.
      J. Biol. Chem.274:32461-32468(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Haploid germ cell specific gene."
      Tanaka H. , Koga M. , Nishimune Y.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Olfactory bulb.
      tissue: Retina.
      tissue: Testis.
      tissue: Thymus.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 154-627
    7. 7.
      "Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells."
      Oyhenart J. , Benichou S. , Raich N.
      Biol. Reprod.72:780-787(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PHTF1
    8. 8.
      "Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene."
      Lu D. , Ventura-Holman T. , Li J. , McMurray R.W. , Subauste J.S. , Maher J.F.
      Mol. Cell. Biol.25:6570-6577(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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