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Index > Protein center > Fga(Gene name) > Rat
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  • Fga (Gene name),
  • Fibrinogen alpha chain (Protein name ),  FIBA_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fga;
    Protein name:
    Fibrinogen alpha chain;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    Function:
    Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    782
    Sequence:
    50:
    MLSLRVACLI | LSLASTVWTA | DTGTTSEFIE | AGGDIRGPRI | VERQPSQCKE | 
    100:
    TDWPFCSDED | WNHKCPSGCR | MKGLIDEANQ | DFTNRINKLK | NSLFDFQKNN | 
    150:
    KDSNSLTRNI | MEYLRGDFAN | ANNFDNTFGQ | VSEDLRRRIQ | ILKRKVIEKA | 
    200:
    QQIQVLQKDV | RDQLIDMKRL | EVDIDIKIRS | CKGSCSRSVS | REINLKDYEG | 
    250:
    QQKQLEQVIA | KDLLPAKDRQ | YLPAIKMSPV | PDLVPGSFKS | QLQEGPPEWK | 
    300:
    ALTEMRQMRM | ELERPGKDGA | SRGDLPGDSR | GDSATRGPGS | KIENPMTPGH | 
    350:
    GGSGYWRPGS | SGSGSDGNWG | SGTTGSDDTG | TWGAGSSRPS | SGSGNLKPSN | 
    400:
    PDWGEFSEFG | GSSSPATRKE | YHTGKLVTSK | GDKELLIGNE | KVTSTGTSTT | 
    450:
    RRSCSKTITK | TVLGNDGHRE | VVKEVVTSDD | GSDCGDGMDL | GLTHSFSGRL | 
    500:
    DELSRMHPEL | GSFYDSRFGS | LTSNFKEFGS | KTSDSDIFTD | IENPSSHVPE | 
    550:
    FSSSSKTSTV | RKQVTKSYKM | ADEAASEAHQ | EGDTRTTKRG | RARTMRDCDD | 
    600:
    VLQTHPSGAQ | NGIFSIKLPG | SSKIFSVYCD | QETSLGGWLL | IQQRMDGSLN | 
    650:
    FNRTWQDYKR | GFGSLNDKGE | GEFWLGNDYL | HLLTLRGSVL | RVELEDWAGK | 
    700:
    EAYAEYHFRV | GSEAEGYALQ | VSSYQGTAGD | ALMEGSVEEG | TEYTSHSNMQ | 
    750:
    FSTFDRDADQ | WEENCAEVYG | GGWWYNSCQA | ANLNGIYYPG | GTYDPRNNSP | 
    782:
    YEIENGVLWV | PFRGADYSLW | AVRMKIRPLV | GQ
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    ELISA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    CLIA Kit for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Polyclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Monoclonal Antibody for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain
    Protein for Rat Fibrinogen alpha chain

    R&D Technical Data
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    s

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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤9.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤12.4%

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    Recovery
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    Recovery was determined by spiking various levels of FIBA into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    105

    96-108

    Plasma

    104

    100-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of FIBA and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    102-110%

    104-112%

    98-106%

    96-106%

    EDTA plasma(n=5)

    103-108%

    96-105%

    98-107%

    102-108%

    heparin plasma(n=5)

    95-110%

     

    96-102%

    101-106%

    105-109%

     

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    References
    1. 1.
      "Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates."
      Fu Y. , Cao Y. , Hertzberg K.M. , Grieninger G.
      Genomics30:71-76(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Evolution and structure of the fibrinogen genes. Random insertion of introns or selective loss?"
      Crabtree G.R. , Comeau C.M. , Fowlkes D.M. , Fornace A.J. Jr. , Malley J.D. , Kant J.A.
      J. Mol. Biol.185:1-19(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
    3. 3.
      "Studies on fibrinopeptides from mammals."
      Blombaeck B. , Blombaeck M. , Grondahl N.J.
      Acta Chem. Scand.19:1789-1791(1965)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-36
    4. 4.
      "Molecular cloning of mRNA sequences transiently induced during rat liver regeneration."
      Sobczak J. , Lotti A.-M. , Taroux P. , Duguet M.
      Exp. Cell Res.169:47-56(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 458-550 (ISOFORM 2)
      strain: Wistar.
      tissue: Liver.
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