FLNC ELISA Kit for Human(Homo sapiens) | EIAab.comFLNC ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FLNC(Gene name) > Human

FLNC (Gene name),

Filamin-C (Protein name ), FLNC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FLNC(ABPL;FLN2);

Protein name:

Filamin-C(FLN-C;FLNc);

Alternative:

ABP-L;ABP-280-like protein;Filamin-2;Actin-binding-like protein;Gamma-filamin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with KY. Interacts with IGFN1 (By similarity). Interacts with FLNB, KCND2, ITGB1A, INPPL1, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only).

Function:

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Cytoplasm cytoskeleton Cytoplasm myofibril sarcomere Z line A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme.

Protein Attributes:

Sequence length:

2725

Sequence:

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2725:

KGDYILIVKW | GDESVPGSPF | KVKVP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2318

Pfam:

PF00307

UniGene:

Hs.58414

String:

Q14315

SMR:

Q14315

MIM:

102565

STRING:

9606.ENSP00000327145

Uniprot:

Q14315

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ELISA Kit for Human FLN-C

Cat.:

E11397h

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96T

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ELISA Kit for Human FLN-C

Cat.:

E11397m

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Manual:

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Packing:

96T

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CLIA Kit for Human FLN-C

Cat.:

U11397h

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MSDS:

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Packing:

96T

CLIA Kit for Human FLN-C

Cat.:

U11397m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human FLN-C

Cat.:

P11397Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human FLN-C

Monoclonal Antibody for Human FLN-C

Protein for Human FLN-C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of human ABPL, an actin-binding protein homologue."
Xie Z.-W. , Xu W.-F. , Davie E.W. , Chung D.W.
Biochem. Biophys. Res. Commun.251:914-919(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS GLY-1580; ALA-1599 AND PRO-2203
tissue: Heart.
2.

"Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family."
Chakarova C. , Wehnert M.S. , Uhl K. , Sakthivel S. , Vosberg H.-P. , van der Ven P.F.M. , Fuerst D.O.
Hum. Genet.107:597-611(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);GENE ORGANIZATION;SIMILARITY TO OTHER MEMBERS OF THE FAMILY
3.

"Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation."
van der Ven P.F.M. , Obermann W.M.J. , Lemke B. , Gautel M. , Weber K. , Fuerst D.O.
Cell Motil. Cytoskeleton45:149-162(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS GLY-1580; ALA-1599; ARG-2135 AND PRO-2203
4.

"Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein."
Thompson T.G. , Chan Y.-M. , Hack A.A. , Brosius M. , Rajala M. , Lidov H.G.W. , McNally E.M. , Watkins S. , Kunkel L.M.
J. Cell Biol.148:115-126(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH SGCD AND SGCG
tissue: Skeletal muscle.
5.

Kato S.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Bienvenut W.V. , Pchelintsev N. , Adams P.D.
Submitted (2009-10) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 70-81; 165-183; 335-343; 350-377; 422-437; 559-573; 576-588; 718-727; 880-895; 900-911; 917-968; 978-991; 1015-1027; 1074-1088; 1147-1157; 1242-1278; 1300-1313; 1355-1367; 1377-1394; 1475-1494; 1568-1586; 1616-1627; 1658-1671; 1714-1719; 1809-1825; 1840-1860; 1886-1901; 1932-1945; 1954-1968; 2000-2008; 2031-2043; 2050-2083; 2114-2127; 2231-2291; 2294-2316; 2327-2356; 2411-2437; 2577-2589; 2597-2616; 2642-2653 AND 2691-2699;PHOSPHORYLATION AT SER-2233;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Lung fibroblast.
9.

"Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7."
Maestrini E. , Patrosso C. , Mancini M. , Rivella S. , Rocchi M. , Repetto M. , Villa A. , Frattini A. , Zoppe M. , Vezzoni P. , Toniolo D.
Hum. Mol. Genet.2:761-766(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 585-815 AND 1638-2101 (ISOFORM 2);TISSUE SPECIFICITY
10.

"FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle."
Faulkner G. , Pallavicini A. , Comelli A. , Salamon M. , Bortoletto G. , Ievolella C. , Trevisan S. , Kojic' S. , Dalla Vecchia F. , Laveder P. , Valle G. , Lanfranchi G.
J. Biol. Chem.275:41234-41242(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOZ1
11.

"Indications for a novel muscular dystrophy pathway: gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin."
van der Ven P.F.M. , Wiesner S. , Salmikangas P. , Auerbach D. , Himmel M. , Kempa S. , Hayess K. , Pacholsky D. , Taivainen A. , Schroeder R. , Carpen O. , Fuerst D.O.
J. Cell Biol.151:235-248(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DOMAIN;INTERACTION WITH MYOT
12.

"Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin."
Petrecca K. , Miller D.M. , Shrier A.
J. Neurosci.20:8736-8744(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCND2
13.

"Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines."
Takada F. , Vander Woude D.L. , Tong H.-Q. , Thompson T.G. , Watkins S.C. , Kunkel L.M. , Beggs A.H.
Proc. Natl. Acad. Sci. U.S.A.98:1595-1600(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOZ1
14.

"The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin."
Dyson J.M. , O'Malley C.J. , Becanovic J. , Munday A.D. , Berndt M.C. , Coghill I.D. , Nandurkar H.H. , Ooms L.M. , Mitchell C.A.
J. Cell Biol.155:1065-1079(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPPL1
15.

"Filamins as integrators of cell mechanics and signalling."
Stossel T.P. , Condeelis J. , Cooley L. , Hartwig J.H. , Noegel A. , Schleicher M. , Shapiro S.S.
Nat. Rev. Mol. Cell Biol.2:138-145(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Identification of silencing of nine genes in human gastric cancers."
Kaneda A. , Kaminishi M. , Yanagihara K. , Sugimura T. , Ushijima T.
Cancer Res.62:6645-6650(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SILENCING IN CANCER CELL LINES MKN28 AND MKN74
17.

"Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins."
Frey N. , Olson E.N.
J. Biol. Chem.277:13998-14004(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOZ3
18.

"The limits of promiscuity: isoform-specific dimerization of filamins."
Himmel M. , van der Ven P.F.M. , Stoecklein W. , Fuerst D.O.
Biochemistry42:430-439(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIMERIZATION;INTERACTION WITH FLNB
19.

"A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy."
Vorgerd M. , van der Ven P.F.M. , Bruchertseifer V. , Loewe T. , Kley R.A. , Schroeder R. , Lochmueller H. , Himmel M. , Koehler K. , Fuerst D.O. , Huebner A.
Am. J. Hum. Genet.77:297-304(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MFM5
20.

"The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
Gontier Y. , Taivainen A. , Fontao L. , Sonnenberg A. , van der Flier A. , Carpen O. , Faulkner G. , Borradori L.
J. Cell Sci.118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGB1; MYOT AND MYOZ1
21.

"The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."
Bosch-Comas A. , Lindsten K. , Gonzalez-Duarte R. , Masucci M.G. , Marfany G.
Cell. Mol. Life Sci.63:723-734(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP25
22.

"Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP."
van der Ven P.F.M. , Ehler E. , Vakeel P. , Eulitz S. , Schenk J.A. , Milting H. , Micheel B. , Fuerst D.O.
Exp. Cell Res.312:2154-2167(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH XIRP1
23.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1161;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
24.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2233;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C."
Maiweilidan Y. , Klauza I. , Kordeli E.
Exp. Cell Res.317:724-736(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANK3
27.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2233;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo."
Spaich S. , Will R.D. , Just S. , Spaich S. , Kuhn C. , Frank D. , Berger I.M. , Wiemann S. , Korn B. , Koegl M. , Backs J. , Katus H.A. , Rottbauer W. , Frey N.
Circ. Res.111:1504-1516(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY FBXL22
29.

"Structural basis for vertebrate filamin dimerization."
Pudas R. , Kiema T.-R. , Butler P.J.G. , Stewart M. , Ylaenne J.
Structure13:111-119(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 2633-2725;MUTAGENESIS OF MET-2669
30.

"Solution structure of the filamin domains from human filamin C."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1536-2599
31.

"Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer."
Sjekloca L. , Pudas R. , Sjoblom B. , Konarev P. , Carugo O. , Rybin V. , Kiema T.R. , Svergun D. , Ylanne J. , Djinovic Carugo K.
J. Mol. Biol.368:1011-1023(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 2495-2598;SUBUNIT
32.

"Migfilin, a molecular switch in regulation of integrin activation."
Ithychanda S.S. , Das M. , Ma Y.Q. , Ding K. , Wang X. , Gupta S. , Wu C. , Plow E.F. , Qin J.
J. Biol. Chem.284:4713-4722(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2302-2415 IN COMPLEX WITH FBLIM1
33.

"Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy."
Duff R.M. , Tay V. , Hackman P. , Ravenscroft G. , McLean C. , Kennedy P. , Steinbach A. , Schoffler W. , van der Ven P.F. , Furst D.O. , Song J. , Djinovic-Carugo K. , Penttila S. , Raheem O. , Reardon K. , Malandrini A. , Gambelli S. , Villanova M. , more...
Am. J. Hum. Genet.88:729-740(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPD4 THR-193 AND THR-251;CHARACTERIZATION OF VARIANTS MPD4 THR-193 AND THR-251

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