FOLR1 ELISA Kit for Human(Homo sapiens) | EIAab.comFOLR1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > FOLR1(Gene name) > Human

FOLR1 (Gene name),

Folate receptor alpha (Protein name ), FOLR1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

FOLR1(FOLR);

Protein name:

Folate receptor alpha(FR-alpha);

Alternative:

Folate receptor 1;Adult folate-binding protein(FBP);KB cells FBP;Folate receptor, adult;Ovarian tumor-associated antigen MOv18;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.

Subcellular Location:

Cell membrane Lipid-anchor GPI-anchor Secreted

Protein Attributes:

Sequence length:

257

Sequence:

50:

100:

150:

200:

250:

257:

MLLWLLS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.73769

STRING:

9606.ENSP00000308137

MIM:

136430

String:

P15328

Pfam:

PF03024

KEGG:

hsa:2348

SMR:

P15328

Uniprot:

P15328

FOR

ELISA Kit for Human FR-alpha

Cat.:

E1599h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human FR-alpha

Cat.:

E1599m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human FR-alpha

Cat.:

E1599b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FR-alpha

Cat.:

U1599m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FR-alpha

Cat.:

U1599b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human FR-alpha

Cat.:

U1599h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human FR-alpha

Cat.:

P1599Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human FR-alpha

Cat.:

P1599Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human FR-alpha

Protein for Human FR-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells."
Elwood P.C.
J. Biol. Chem.264:14893-14901(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION;GLYCOSYLATION;TISSUE SPECIFICITY
2.

"Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol."
Lacey S.W. , Sanders J.M. , Rothberg K.G. , Anderson R.G.W. , Kamen B.A.
J. Clin. Invest.84:715-720(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
3.

"Folate-binding protein is a marker for ovarian cancer."
Campbell I.G. , Jones T.A. , Foulkes W.D. , Trowsdale J.
Cancer Res.51:5329-5338(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Ovary.
4.

"Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein."
Coney L.R. , Tomassetti A. , Carayannopoulos L. , Frasca V. , Kamen B.A. , Colnaghi M.I. , Zurawski V.R. Jr.
Cancer Res.51:6125-6132(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-56
tissue: Ovarian carcinoma.
5.

"Genomic organization of the gene and a related pseudogene for a human folate binding protein."
Sadasivan E. , Cedeno M. , Rothenberg S.P.
Biochim. Biophys. Acta1131:91-94(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure."
Elwood P.C. , Nachmanoff K. , Saikawa Y. , Page S.T. , Pacheco P. , Roberts S. , Chung K.-N.
Biochemistry36:1467-1478(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];NUCLEOTIDE SEQUENCE [MRNA] OF 1-56;TISSUE SPECIFICITY
tissue: Lymphocyte.
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney proximal tubule.
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
12.

"The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA."
Sadasivan E. , Rothenberg S.P.
J. Biol. Chem.264:5806-5811(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-249
13.

"Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation."
Luhrs C.A. , Pitiranggon P. , da Costa M. , Rothenberg S.P. , Slomiany B.L. , Brink L. , Tous G.I. , Stein S.
Proc. Natl. Acad. Sci. U.S.A.84:6546-6549(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-43;SUBCELLULAR LOCATION
14.

"UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor."
Orr R.B. , Kamen B.A.
Cancer Res.54:3905-3911(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
15.

"Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal."
Yan W. , Ratnam M.
Biochemistry34:14594-14600(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT SER-234;SUBCELLULAR LOCATION
16.

"Endocytosis of GPI-linked membrane folate receptor-alpha."
Rijnboutt S. , Jansen G. , Posthuma G. , Hynes J.B. , Schornagel J.H. , Strous G.J.
J. Cell Biol.132:35-47(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;GLYCOSYLATION;SUBCELLULAR LOCATION
17.

"Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
Elortza F. , Nuehse T.S. , Foster L.J. , Stensballe A. , Peck S.C. , Jensen O.N.
Mol. Cell. Proteomics2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
Elortza F. , Mohammed S. , Bunkenborg J. , Foster L.J. , Nuehse T.S. , Brodbeck U. , Peck S.C. , Jensen O.N.
J. Proteome Res.5:935-943(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments."
Omaetxebarria M.J. , Elortza F. , Rodriguez-Suarez E. , Aloria K. , Arizmendi J.M. , Jensen O.N. , Matthiesen R.
Proteomics7:1951-1960(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR AT SER-234;IDENTIFICATION BY MASS SPECTROMETRY
20.

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-161 AND ASN-201
tissue: Milk.
21.

"Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism."
Steinfeld R. , Grapp M. , Kraetzner R. , Dreha-Kulaczewski S. , Helms G. , Dechent P. , Wevers R. , Grosso S. , Gaertner J.
Am. J. Hum. Genet.85:354-363(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NEURODEGENERATION DUE TO CEREBRAL FOLATE TRANSPORT DEFICIENCY
22.

"Structural basis for molecular recognition of folic acid by folate receptors."
Chen C. , Ke J. , Zhou X.E. , Yi W. , Brunzelle J.S. , Li J. , Yong E.L. , Xu H.E. , Melcher K.
Nature500:486-489(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 23-235 IN COMPLEX WITH FOLATE;FUNCTION;MUTAGENESIS OF TYR-82; ASP-103; TYR-107; TRP-124; ARG-125; ARG-128; HIS-157; TRP-162 AND SER-196;DISULFIDE BONDS;GLYCOSYLATION AT ASN-69; ASN-161 AND ASN-201
23.

"Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition."
Wibowo A.S. , Singh M. , Reeder K.M. , Carter J.J. , Kovach A.R. , Meng W. , Ratnam M. , Zhang F. , Dann C.E. III
Proc. Natl. Acad. Sci. U.S.A.110:15180-15188(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 30-234;FUNCTION;GLYCOSYLATION AT ASN-69; ASN-161 AND ASN-201;DISULFIDE BONDS

Product Feedback Wall

* Email:
*Comments: