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Index > Protein center > FOXP1(Gene name) > Human
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  • FOXP1 (Gene name),
  • Forkhead box protein P1 (Protein name ),  FOXP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    FOXP1(HSPC215);
    Protein name:
    Forkhead box protein P1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.
    Function:
    Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    677
    Sequence:
    50:
    MMQESGTETK | SNGSAIQNGS | GGSNHLLECG | GLREGRSNGE | TPAVDIGAAD | 
    100:
    LAHAQQQQQQ | ALQVARQLLL | QQQQQQQVSG | LKSPKRNDKQ | PALQVPVSVA | 
    150:
    MMTPQVITPQ | QMQQILQQQV | LSPQQLQVLL | QQQQALMLQQ | QQLQEFYKKQ | 
    200:
    QEQLQLQLLQ | QQHAGKQPKE | QQQVATQQLA | FQQQLLQMQQ | LQQQHLLSLQ | 
    250:
    RQGLLTIQPG | QPALPLQPLA | QGMIPTELQQ | LWKEVTSAHT | AEETTGNNHS | 
    300:
    SLDLTTTCVS | SSAPSKTSLI | MNPHASTNGQ | LSVHTPKRES | LSHEEHPHSH | 
    350:
    PLYGHGVCKW | PGCEAVCEDF | QSFLKHLNSE | HALDDRSTAQ | CRVQMQVVQQ | 
    400:
    LELQLAKDKE | RLQAMMTHLH | VKSTEPKAAP | QPLNLVSSVT | LSKSASEASP | 
    450:
    QSLPHTPTTP | TAPLTPVTQG | PSVITTTSMH | TVGPIRRRYS | DKYNVPISSA | 
    500:
    DIAQNQEFYK | NAEVRPPFTY | ASLIRQAILE | SPEKQLTLNE | IYNWFTRMFA | 
    550:
    YFRRNAATWK | NAVRHNLSLH | KCFVRVENVK | GAVWTVDEVE | FQKRRPQKIS | 
    600:
    GNPSLIKNMQ | SSHAYCTPLN | AALQASMAEN | SIPLYTTASM | GNPTLGNLAS | 
    650:
    AIREELNGAM | EHTNSNESDS | SPGRSPMQAV | HPVHVKEEPL | DPEEAEGPLS | 
    677:
    LVTTANHSPD | FDHDRDYEDE | PVNEDME
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Forkhead box protein P1
    Cat.:
    E15456h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Forkhead box protein P1
    Cat.:
    E15456r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Forkhead box protein P1
    Cat.:
    E15456b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Forkhead box protein P1
    Cat.:
    E15456m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Forkhead box protein P1
    Cat.:
    E15456c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P1
    Cat.:
    U15456c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P1
    Cat.:
    U15456m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P1
    Cat.:
    U15456h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P1
    Cat.:
    U15456r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P1
    Cat.:
    U15456b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Forkhead box protein P1
    Polyclonal Antibody for Human Forkhead box protein P1
    Cat.:
    P15456Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Forkhead box protein P1
    Cat.:
    P15456Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Forkhead box protein P1
    Polyclonal Antibody for Human Forkhead box protein P1
    Cat.:
    P15456Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Forkhead box protein P1
    Monoclonal Antibody for Human Forkhead box protein P1
    Monoclonal Antibody for Human Forkhead box protein P1
    Monoclonal Antibody for Human Forkhead box protein P1
    Monoclonal Antibody for Human Forkhead box protein P1
    Protein for Human Forkhead box protein P1
    Protein for Human Forkhead box protein P1
    Protein for Human Forkhead box protein P1
    Protein for Human Forkhead box protein P1
    Protein for Human Forkhead box protein P1

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    References
    1. 1.
      "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p."
      Banham A.H. , Beasley N. , Campo E. , Fernandez P.L. , Fidler C. , Gatter K. , Jones M. , Mason D.Y. , Prime J.E. , Trougouboff P. , Wood K. , Cordell J.L.
      Cancer Res.61:8820-8829(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);NUCLEOTIDE SEQUENCE [MRNA] OF 210-677 (ISOFORM 7);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Testis.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-677 (ISOFORM 4)
      tissue: Embryonic head.
      tissue: Tongue.
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Lung.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-677;CHROMOSOMAL TRANSLOCATION WITH PAX5
    8. 8.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-677
      tissue: Umbilical cord blood.
    9. 9.
      "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1."
      Shi C. , Zhang X. , Chen Z. , Sulaiman K. , Feinberg M.W. , Ballantyne C.M. , Jain M.K. , Simon D.I.
      J. Clin. Invest.114:408-418(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells."
      Takayama K. , Horie-Inoue K. , Ikeda K. , Urano T. , Murakami K. , Hayashizaki Y. , Ouchi Y. , Inoue S.
      Biochem. Biophys. Res. Commun.374:388-393(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AR;INDUCTION BY ANDROGEN
    11. 11.
      "Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function."
      Shi C. , Sakuma M. , Mooroka T. , Liscoe A. , Gao H. , Croce K.J. , Sharma A. , Kaplan D. , Greaves D.R. , Wang Y. , Simon D.I.
      Blood112:4699-4711(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Cooperative regulation in development by SMRT and FOXP1."
      Jepsen K. , Gleiberman A.S. , Shi C. , Simon D.I. , Rosenfeld M.G.
      Genes Dev.22:740-745(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCOR2
    13. 13.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN MRLIAF;VARIANTS ALA-215; MET-445; SER-570 AND ASN-613
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 8);FUNCTION (ISOFORM 8);TISSUE SPECIFICITY (ISOFORM 8)
    16. 16.
      "FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells."
      Grundmann S. , Lindmayer C. , Hans F.P. , Hoefer I. , Helbing T. , Pasterkamp G. , Bode C. , de Kleijn D. , Moser M.
      PLoS ONE8:E70873-E70873(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "FOXP1 directly represses transcription of pro-apoptotic genes and cooperates with NF-kappaB to promote survival of human B-cells."
      van Keimpema M. , Grueneberg L.J. , Mokry M. , van Boxtel R. , Koster J. , Coffer P.J. , Pals S.T. , Spaargaren M.
      Blood0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization."
      Sin C. , Li H. , Crawford D.A.
      J. Mol. Neurosci.0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FOXP2 AND FOXP4;SUBCELLULAR LOCATION
    19. 19.
      "Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding."
      Chu Y.P. , Chang C.H. , Shiu J.H. , Chang Y.T. , Chen C.Y. , Chuang W.J.
      Protein Sci.20:908-924(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 462-548
    20. 20.
      "Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia."
      Vernes S.C. , MacDermot K.D. , Monaco A.P. , Fisher S.E.
      Eur. J. Hum. Genet.17:1354-1358(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-215
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PRO-5; VAL-101; ALA-215; PRO-261; SER-390; SER-570 AND THR-597
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