Gene name:
FOXP1 (HSPC215) ;
Protein name:
Forkhead box protein P1 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.
Function:
Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MMQESGTETK | SNGSAIQNGS | GGSNHLLECG | GLREGRSNGE | TPAVDIGAAD |
100:
LAHAQQQQQQ | ALQVARQLLL | QQQQQQQVSG | LKSPKRNDKQ | PALQVPVSVA |
150:
MMTPQVITPQ | QMQQILQQQV | LSPQQLQVLL | QQQQALMLQQ | QQLQEFYKKQ |
200:
QEQLQLQLLQ | QQHAGKQPKE | QQQVATQQLA | FQQQLLQMQQ | LQQQHLLSLQ |
250:
RQGLLTIQPG | QPALPLQPLA | QGMIPTELQQ | LWKEVTSAHT | AEETTGNNHS |
300:
SLDLTTTCVS | SSAPSKTSLI | MNPHASTNGQ | LSVHTPKRES | LSHEEHPHSH |
350:
PLYGHGVCKW | PGCEAVCEDF | QSFLKHLNSE | HALDDRSTAQ | CRVQMQVVQQ |
400:
LELQLAKDKE | RLQAMMTHLH | VKSTEPKAAP | QPLNLVSSVT | LSKSASEASP |
450:
QSLPHTPTTP | TAPLTPVTQG | PSVITTTSMH | TVGPIRRRYS | DKYNVPISSA |
500:
DIAQNQEFYK | NAEVRPPFTY | ASLIRQAILE | SPEKQLTLNE | IYNWFTRMFA |
550:
YFRRNAATWK | NAVRHNLSLH | KCFVRVENVK | GAVWTVDEVE | FQKRRPQKIS |
600:
GNPSLIKNMQ | SSHAYCTPLN | AALQASMAEN | SIPLYTTASM | GNPTLGNLAS |
650:
AIREELNGAM | EHTNSNESDS | SPGRSPMQAV | HPVHVKEEPL | DPEEAEGPLS |
677:
LVTTANHSPD | FDHDRDYEDE | PVNEDME
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
Chicken
ELISA Kit for Human Forkhead box protein P1
ELISA Kit for Human Forkhead box protein P1
ELISA Kit for Human Forkhead box protein P1
ELISA Kit for Human Forkhead box protein P1
ELISA Kit for Human Forkhead box protein P1
CLIA Kit for Human Forkhead box protein P1
CLIA Kit for Human Forkhead box protein P1
CLIA Kit for Human Forkhead box protein P1
CLIA Kit for Human Forkhead box protein P1
CLIA Kit for Human Forkhead box protein P1
Polyclonal Antibody for Human Forkhead box protein P1
Polyclonal Antibody for Human Forkhead box protein P1
Polyclonal Antibody for Human Forkhead box protein P1
Polyclonal Antibody for Human Forkhead box protein P1
Polyclonal Antibody for Human Forkhead box protein P1
Monoclonal Antibody for Human Forkhead box protein P1
Monoclonal Antibody for Human Forkhead box protein P1
Monoclonal Antibody for Human Forkhead box protein P1
Monoclonal Antibody for Human Forkhead box protein P1
Monoclonal Antibody for Human Forkhead box protein P1
Protein for Human Forkhead box protein P1
Protein for Human Forkhead box protein P1
Protein for Human Forkhead box protein P1
Protein for Human Forkhead box protein P1
Protein for Human Forkhead box protein P1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);NUCLEOTIDE SEQUENCE [MRNA] OF 210-677 (ISOFORM 7);PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-677 (ISOFORM 4)
tissue :
Embryonic head .
tissue :
Tongue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue :
Lung .
7.
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Nature446:758-764(2007)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 60-677;CHROMOSOMAL TRANSLOCATION WITH PAX5
8.
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H.
,
Ye M.
,
Wu X.-Y.
,
Ren S.-X.
,
Zhao M.
,
Zhao C.-J.
,
Fu G.
,
Shen Y.
,
Fan H.-Y.
,
Lu G.
,
Zhong M.
,
Xu X.-R.
,
Han Z.-G.
,
Zhang J.-W.
,
Tao J.
,
Huang Q.-H.
,
Zhou J.
,
Hu G.-X.
,
Gu J.
,
Chen S.-J.
,
Chen Z.
more...
Genome Res.10:1546-1560(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-677
tissue :
Umbilical cord blood .
9.
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Cited for : FUNCTION
10.
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Cited for : FUNCTION;INTERACTION WITH AR;INDUCTION BY ANDROGEN
11.
"Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function."
Shi C.
,
Sakuma M.
,
Mooroka T.
,
Liscoe A.
,
Gao H.
,
Croce K.J.
,
Sharma A.
,
Kaplan D.
,
Greaves D.R.
,
Wang Y.
,
Simon D.I.
Blood112:4699-4711(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NCOR2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
"De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment."
Hamdan F.F.
,
Daoud H.
,
Rochefort D.
,
Piton A.
,
Gauthier J.
,
Langlois M.
,
Foomani G.
,
Dobrzeniecka S.
,
Krebs M.O.
,
Joober R.
,
Lafreniere R.G.
,
Lacaille J.C.
,
Mottron L.
,
Drapeau P.
,
Beauchamp M.H.
,
Phillips M.S.
,
Fombonne E.
,
Rouleau G.A.
,
Michaud J.L.
more...
Am. J. Hum. Genet.87:671-678(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;INVOLVEMENT IN MRLIAF;VARIANTS ALA-215; MET-445; SER-570 AND ASN-613
15.
"An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming."
Gabut M.
,
Samavarchi-Tehrani P.
,
Wang X.
,
Slobodeniuc V.
,
O'Hanlon D.
,
Sung H.K.
,
Alvarez M.
,
Talukder S.
,
Pan Q.
,
Mazzoni E.O.
,
Nedelec S.
,
Wichterle H.
,
Woltjen K.
,
Hughes T.R.
,
Zandstra P.W.
,
Nagy A.
,
Wrana J.L.
,
Blencowe B.J.
Cell147:132-146(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ALTERNATIVE SPLICING (ISOFORM 8);FUNCTION (ISOFORM 8);TISSUE SPECIFICITY (ISOFORM 8)
16.
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Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
18.
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Cited for : INTERACTION WITH FOXP2 AND FOXP4;SUBCELLULAR LOCATION
19.
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Cited for : STRUCTURE BY NMR OF 462-548
20.
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Cited for : VARIANT ALA-215
21.
"Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits."
Horn D.
,
Kapeller J.
,
Rivera-Brugues N.
,
Moog U.
,
Lorenz-Depiereux B.
,
Eck S.
,
Hempel M.
,
Wagenstaller J.
,
Gawthrope A.
,
Monaco A.P.
,
Bonin M.
,
Riess O.
,
Wohlleber E.
,
Illig T.
,
Bezzina C.R.
,
Franke A.
,
Spranger S.
,
Villavicencio-Lorini P.
,
Seifert W.
,
Rosenfeld J.
,
Klopocki E.
,
Rappold G.A.
,
Strom T.M.
more...
Hum. Mutat.31:E1851-E1860(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PRO-5; VAL-101; ALA-215; PRO-261; SER-390; SER-570 AND THR-597