Gene name:
FSTL3 (UNQ674/PRO1308;FLRG) ;
Protein name:
Follistatin-related protein 3 ;
Alternative:
Follistatin-related gene protein ;Follistatin-like protein 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.
Function:
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Subcellular Location:
Isoform 2
Nucleus
Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initation at Met-27 according to.
Protein Attributes:
50:
MRPGAPGPLW | PLPWGALAWA | VGFVSSMGSG | NPAPGGVCWL | QQGQEATCSL |
100:
VLQTDVTRAE | CCASGNIDTA | WSNLTHPGNK | INLLGFLGLV | HCLPCKDSCD |
150:
GVECGPGKAC | RMLGGRPRCE | CAPDCSGLPA | RLQVCGSDGA | TYRDECELRA |
200:
ARCRGHPDLS | VMYRGRCRKS | CEHVVCPRPQ | SCVVDQTGSA | HCVVCRAAPC |
250:
PVPSSPGQEL | CGNNNVTYIS | SCHMRQATCF | LGRSIGVRHA | GSCAGTPEEP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Human Follistatin-related protein 3
ELISA Kit for Human Follistatin-related protein 3
ELISA Kit for Human Follistatin-related protein 3
ELISA Kit for Human Follistatin-related protein 3
CLIA Kit for Human Follistatin-related protein 3
CLIA Kit for Human Follistatin-related protein 3
CLIA Kit for Human Follistatin-related protein 3
CLIA Kit for Human Follistatin-related protein 3
Polyclonal Antibody for Human Follistatin-related protein 3
Polyclonal Antibody for Human Follistatin-related protein 3
Polyclonal Antibody for Human Follistatin-related protein 3
Polyclonal Antibody for Human Follistatin-related protein 3
Monoclonal Antibody for Human Follistatin-related protein 3
Monoclonal Antibody for Human Follistatin-related protein 3
Monoclonal Antibody for Human Follistatin-related protein 3
Monoclonal Antibody for Human Follistatin-related protein 3
Protein for Human Follistatin-related protein 3
Protein for Human Follistatin-related protein 3
Protein for Human Follistatin-related protein 3
Protein for Human Follistatin-related protein 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Placenta .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-41
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH INHBA AND INHBB
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HEMATOPOIESIS
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN OSTEOCLAST DIFFERENTIATION;INTERACTION WITH ADAM8 AND ADAM12
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;ALTERNATIVE INITIATION;MUTAGENESIS OF MET-27
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HEMATOPOIESIS;INTERACTION WITH FN1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN TRANSCRIPTION REGULATION;INTERACTION WITH MLLT10
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MSTN
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 27-263 IN COMPLEX WITH INHBA;DISULFIDE BONDS;GLYCOSYLATION AT ASN-215
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 36-244 IN COMPLEX WITH MOUSE GDF8;GLYCOSYLATION AT ASN-73;DISULFIDE BONDS