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Index > Protein center > FUT3(Gene name) > Human
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  • FUT3 (Gene name),
  • Galactoside 3(4)-L-fucosyltransferase (Protein name ),  FUT3_HUMAN from NCBI database.
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  • Gene name:
    FUT3(FT3B;LE);
    Protein name:
    Galactoside 3(4)-L-fucosyltransferase;
    Alternative:
    Fucosyltransferase 3;Blood group Lewis alpha-4-fucosyltransferase(Lewis FT);Fucosyltransferase III(FucT-III);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Membrane-bound form in trans cisternae of Golgi.
    Protein Attributes:
    Sequence length:
    361
    Sequence:
    50:
    MDPLGAAKPQ | WPWRRCLAAL | LFQLLVAVCF | FSYLRVSRDD | ATGSPRAPSG | 
    100:
    SSRQDTTPTR | PTLLILLWTW | PFHIPVALSR | CSEMVPGTAD | CHITADRKVY | 
    150:
    PQADTVIVHH | WDIMSNPKSR | LPPSPRPQGQ | RWIWFNLEPP | PNCQHLEALD | 
    200:
    RYFNLTMSYR | SDSDIFTPYG | WLEPWSGQPA | HPPLNLSAKT | ELVAWAVSNW | 
    250:
    KPDSARVRYY | QSLQAHLKVD | VYGRSHKPLP | KGTMMETLSR | YKFYLAFENS | 
    300:
    LHPDYITEKL | WRNALEAWAV | PVVLGPSRSN | YERFLPPDAF | IHVDDFQSPK | 
    350:
    DLARYLQELD | KDHARYLSYF | RWRETLRPRS | FSWALDFCKA | CWKLQQESRY | 
    361:
    QTVRSIAAWF | T
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Galactoside 3(4)-L-fucosyltransferase
    Cat.:
    E8997h
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    Packing:
    96T
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    ELISA Kit for Human Galactoside 3(4)-L-fucosyltransferase
    Cat.:
    E8997b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Galactoside 3(4)-L-fucosyltransferase
    Cat.:
    U8997b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Galactoside 3(4)-L-fucosyltransferase
    Cat.:
    U8997h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Galactoside 3(4)-L-fucosyltransferase
    Polyclonal Antibody for Human Galactoside 3(4)-L-fucosyltransferase
    Cat.:
    P8997Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Galactoside 3(4)-L-fucosyltransferase
    Monoclonal Antibody for Human Galactoside 3(4)-L-fucosyltransferase
    Protein for Human Galactoside 3(4)-L-fucosyltransferase
    Protein for Human Galactoside 3(4)-L-fucosyltransferase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals."
      Nishihara S. , Yazawa S. , Iwasaki H. , Nakazato M. , Kudo T. , Ando T. , Narimatsu H.
      Biochem. Biophys. Res. Commun.196:624-631(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(-) ARG-20; SER-170 AND ALA-336
    2. 2.
      "Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals."
      Koda Y. , Kimura H. , Mekada E.
      Blood82:2915-2919(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(-) ARG-20 AND SER-170
    3. 3.
      "Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees."
      Mollicone R. , Reguigne I. , Kelly R.J. , Fletcher A. , Watt J. , Chatfield S. , Aziz A. , Cameron H.S. , Weston B.W. , Lowe J.B. , Oriol R.
      J. Biol. Chem.269:20987-20994(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(-) ARG-20 AND LYS-356
    4. 4.
      "Molecular genetic analysis of the human Lewis histo-blood group system."
      Nishihara S. , Narimatsu H. , Iwasaki H. , Yazawa S. , Akamatsu S. , Ando T. , Seno T. , Narimatsu I.
      J. Biol. Chem.269:29271-29278(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LE(-) LYS-356
    5. 5.
      "DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system."
      Elmgren A. , Boerjeson C. , Svensson L. , Rydberg L. , Larson G.
      Vox Sang.70:97-103(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(-) ARG-20; ARG-68; MET-105 AND LYS-356
    6. 6.
      "Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII."
      Elmgren A. , Mollicone R. , Costache M. , Boerjeson C. , Oriol R. , Harrington J. , Larson G.
      J. Biol. Chem.272:21994-21998(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(-) ARG-68 AND MET-105
    7. 7.
      "Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa."
      Pang H. , Liu Y. , Koda Y. , Soejima M. , Jia J. , Schlaphoff T. , du Toit E.D. , Kimura H.
      Hum. Genet.102:675-680(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LE(+) LYS-102 AND ALA-124;VARIANTS LE(-) ASN-162; ARG-223 AND MET-270
    8. 8.
      "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase."
      Kukowska-Latallo J.F. , Larsen R.D. , Nair R.P. , Lowe J.B.
      Genes Dev.4:1288-1303(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    9. 9.
      "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms."
      Cameron H.S. , Szczepaniak D. , Weston B.W.
      J. Biol. Chem.270:20112-20122(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    10. 10.
      "Isolation and expression of human alpha (1,3/1,4) fucosyltransferase."
      Rahim I. , Schmidt L.R. , Wahl D. , Drayson E. , Maslanik W. , Stranahan P.L. , Pettijohn D.E.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Squamous cell carcinoma.
    11. 11.
      "Allele frequencies of fucosyltransferases 1, 2, and 3 of Styrian blood donors."
      Matzhold E.M.
      Submitted (2008-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-68 AND MET-105
      tissue: Blood.
    12. 12.
      SeattleSNPs variation discovery resource
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-5; ARG-20; ARG-68; MET-105; CYS-160; ASN-162; SER-170; ARG-223; MET-270; MET-325 AND GLN-327
    13. 13.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS ARG-68 AND MET-105
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
      tissue: Lung.
    15. 15.
      "Genotypic heterogeneity among Lewis negative individuals."
      Elmgren A. , Rydberg L. , Larson G.
      Biochem. Biophys. Res. Commun.196:515-520(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LE(-) MET-105
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