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Index > Protein center > FUT8(Gene name) > Human
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  • FUT8 (Gene name),
  • Alpha-(1,6)-fucosyltransferase (Protein name ),  FUT8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FUT8;
    Protein name:
    Alpha-(1,6)-fucosyltransferase(alpha1-6FucT);
    Alternative:
    GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase;Fucosyltransferase 8;Glycoprotein 6-alpha-L-fucosyltransferase;GDP-fucose--glycoprotein fucosyltransferase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Membrane-bound form in trans cisternae of Golgi.
    Protein Attributes:
    Sequence length:
    575
    Sequence:
    50:
    MRPWTGSWRW | IMLILFAWGT | LLFYIGGHLV | RDNDHPDHSS | RELSKILAKL | 
    100:
    ERLKQQNEDL | RRMAESLRIP | EGPIDQGPAI | GRVRVLEEQL | VKAKEQIENY | 
    150:
    KKQTRNGLGK | DHEILRRRIE | NGAKELWFFL | QSELKKLKNL | EGNELQRHAD | 
    200:
    EFLLDLGHHE | RSIMTDLYYL | SQTDGAGDWR | EKEAKDLTEL | VQRRITYLQN | 
    250:
    PKDCSKAKKL | VCNINKGCGY | GCQLHHVVYC | FMIAYGTQRT | LILESQNWRY | 
    300:
    ATGGWETVFR | PVSETCTDRS | GISTGHWSGE | VKDKNVQVVE | LPIVDSLHPR | 
    350:
    PPYLPLAVPE | DLADRLVRVH | GDPAVWWVSQ | FVKYLIRPQP | WLEKEIEEAT | 
    400:
    KKLGFKHPVI | GVHVRRTDKV | GTEAAFHPIE | EYMVHVEEHF | QLLARRMQVD | 
    450:
    KKRVYLATDD | PSLLKEAKTK | YPNYEFISDN | SISWSAGLHN | RYTENSLRGV | 
    500:
    ILDIHFLSQA | DFLVCTFSSQ | VCRVAYEIMQ | TLHPDASANF | HSLDDIYYFG | 
    550:
    GQNAHNQIAI | YAHQPRTADE | IPMEPGDIIG | VAGNHWDGYS | KGVNRKLGRT | 
    575:
    GLYPSYKVRE | KIETVKYPTY | PEAEK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human alpha1-6FucT
    ELISA Kit for Human alpha1-6FucT
    ELISA Kit for Human alpha1-6FucT
    ELISA Kit for Human alpha1-6FucT
    ELISA Kit for Human alpha1-6FucT
    ELISA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    CLIA Kit for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Polyclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Monoclonal Antibody for Human alpha1-6FucT
    Protein for Human alpha1-6FucT
    Protein for Human alpha1-6FucT
    Protein for Human alpha1-6FucT
    Protein for Human alpha1-6FucT
    Protein for Human alpha1-6FucT
    Protein for Human alpha1-6FucT

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    Linearity
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    References
    1. 1.
      "Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells."
      Yanagidani S. , Uozumi N. , Ihara Y. , Miyoshi E. , Yamaguchi N. , Taniguchi N.
      J. Biochem.121:626-632(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "Differential splice variants of human FUT8 embryonic cDNA."
      Cailleau A. , Balanzino L. , Candelier J.J. , Oriol R. , Mollicone R.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Embryo.
    3. 3.
      "Genomic structure and promoter analysis of the human alpha1,6-fucosyltransferase gene (FUT8)."
      Yamaguchi Y. , Ikeda Y. , Takahashi T. , Ihara H. , Tanaka T. , Sasho C. , Uozumi N. , Yanagidani S. , Inoue S. , Fujii J. , Taniguchi N.
      Glycobiology10:637-643(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2)
    4. 4.
      "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis."
      Martinez-Duncker I. , Michalski J.C. , Bauvy C. , Candelier J.J. , Mennesson B. , Codogno P. , Oriol R. , Mollicone R.
      Glycobiology14:13-25(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);ALTERNATIVE SPLICING
      tissue: Embryo.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Amygdala.
    6. 6.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Lung.
    8. 8.
      "A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues."
      Takahashi T. , Ikeda Y. , Tateishi A. , Yamaguchi Y. , Ishikawa M. , Taniguchi N.
      Glycobiology10:503-510(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DONOR SUBSTRATE-BINDING;MUTAGENESIS OF ARG-365 AND ARG-366
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    10. 10.
      "Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8."
      Ihara H. , Ikeda Y. , Toma S. , Wang X. , Suzuki T. , Gu J. , Miyoshi E. , Tsukihara T. , Honke K. , Matsumoto A. , Nakagawa A. , Taniguchi N.
      Glycobiology17:455-466(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 68-575;FUNCTION;CATALYTIC ACTIVITY;DISULFIDE BOND;MUTAGENESIS OF ARG-365; ASP-368; LYS-369; GLU-373; TYR-382; ASP-409; ASP-410; ASP-453 AND SER-469
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