Protein name:
    Alpha-(1,6)-fucosyltransferase (alpha1-6FucT) ;
    
    Alternative:
    
    GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase ;Fucosyltransferase 8 ;Glycoprotein 6-alpha-L-fucosyltransferase ;GDP-fucose--glycoprotein fucosyltransferase ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Function:
    Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Golgi apparatus  
      Golgi stack membrane  
      Single-pass type II membrane protein 
      
    Membrane-bound form in trans cisternae of Golgi. 
  
    
 
    
    Protein Attributes:
    
    50:
    MRPWTGSWRW |  IMLILFAWGT |  LLFYIGGHLV |  RDNDHPDHSS |  RELSKILAKL |  
    
 
    100:
    ERLKQQNEDL |  RRMAESLRIP |  EGPIDQGPAI |  GRVRVLEEQL |  VKAKEQIENY |  
    
 
    150:
    KKQTRNGLGK |  DHEILRRRIE |  NGAKELWFFL |  QSELKKLKNL |  EGNELQRHAD |  
    
 
    200:
    EFLLDLGHHE |  RSIMTDLYYL |  SQTDGAGDWR |  EKEAKDLTEL |  VQRRITYLQN |  
    
 
    250:
    PKDCSKAKKL |  VCNINKGCGY |  GCQLHHVVYC |  FMIAYGTQRT |  LILESQNWRY |  
    
 
    300:
    ATGGWETVFR |  PVSETCTDRS |  GISTGHWSGE |  VKDKNVQVVE |  LPIVDSLHPR |  
    
 
    350:
    PPYLPLAVPE |  DLADRLVRVH |  GDPAVWWVSQ |  FVKYLIRPQP |  WLEKEIEEAT |  
    
 
    400:
    KKLGFKHPVI |  GVHVRRTDKV |  GTEAAFHPIE |  EYMVHVEEHF |  QLLARRMQVD |  
    
 
    450:
    KKRVYLATDD |  PSLLKEAKTK |  YPNYEFISDN |  SISWSAGLHN |  RYTENSLRGV |  
    
 
    500:
    ILDIHFLSQA |  DFLVCTFSSQ |  VCRVAYEIMQ |  TLHPDASANF |  HSLDDIYYFG |  
    
 
    550:
    GQNAHNQIAI |  YAHQPRTADE |  IPMEPGDIIG |  VAGNHWDGYS |  KGVNRKLGRT |  
    
 
    575:
    GLYPSYKVRE |  KIETVKYPTY |  PEAEK
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Bovine
         
        
        Human
         
        
        Pig
         
        
        Rat
         
        
        Dog
         
        
        Mouse
         
        
     
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
    
        Protein for Human alpha1-6FucT
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Embryo .  
             
         
            
        
            
                3.
                
                    
                        
                            "Genomic structure and promoter analysis of the human alpha1,6-fucosyltransferase gene (FUT8)." 
                        
                        
                            Yamaguchi Y. 
                        ,
                            
Ikeda Y. 
                        ,
                            
Takahashi T. 
                        ,
                            
Ihara H. 
                        ,
                            
Tanaka T. 
                        ,
                            
Sasho C. 
                        ,
                            
Uozumi N. 
                        ,
                            
Yanagidani S. 
                        ,
                            
Inoue S. 
                        ,
                            
Fujii J. 
                        ,
                            
Taniguchi N. 
                        
                        
                        
                        
                            Glycobiology10:637-643(2000)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2) 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);ALTERNATIVE SPLICING 
                    
                    
                    tissue :
                    
Embryo .  
             
         
            
        
            
                5.
                
                    
                        
                            "Complete sequencing and characterization of 21,243 full-length human cDNAs." 
                        
                        
                            Ota T. 
                        ,
                            
Suzuki Y. 
                        ,
                            
Nishikawa T. 
                        ,
                            
Otsuki T. 
                        ,
                            
Sugiyama T. 
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                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3) 
                    
                    
                    tissue :
                    
Amygdala .  
             
         
            
        
            
                6.
                
                    
                        
                            "The DNA sequence and analysis of human chromosome 14." 
                        
                        
                            Heilig R. 
                        ,
                            
Eckenberg R. 
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Petit J.-L. 
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Fonknechten N. 
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Da Silva C. 
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Cattolico L. 
                        ,
                            
Levy M. 
                        ,
                            
Barbe V. 
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De Berardinis V. 
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Ureta-Vidal A. 
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Pelletier E. 
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Vico V. 
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Anthouard V. 
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Rowen L. 
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Madan A. 
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Qin S. 
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Sun H. 
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Du H. 
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                            Friedlander L. 
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                              more...   
                             
                        
                        
                        
                            Nature421:601-607(2003)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4) 
                    
                    
                    tissue :
                    
Lung .  
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for DONOR SUBSTRATE-BINDING;MUTAGENESIS OF ARG-365 AND ARG-366 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                        
                            "A secreted tyrosine kinase acts in the extracellular environment." 
                        
                        
                            Bordoli M.R. 
                        ,
                            
Yum J. 
                        ,
                            
Breitkopf S.B. 
                        ,
                            
Thon J.N. 
                        ,
                            
Italiano J.E. Jr. 
                        ,
                            
Xiao J. 
                        ,
                            
Worby C. 
                        ,
                            
Wong S.K. 
                        ,
                            
Lin G. 
                        ,
                            
Edenius M. 
                        ,
                            
Keller T.L. 
                        ,
                            
Asara J.M. 
                        ,
                            
Dixon J.E. 
                        ,
                            
Yeo C.Y. 
                        ,
                            
Whitman M. 
                        
                        
                        
                        
                            Cell158:1033-1044(2014)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION 
                    
                    
                 
             
         
            
        
            
                10.
                
                    
                        
                            "Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8." 
                        
                        
                            Ihara H. 
                        ,
                            
Ikeda Y. 
                        ,
                            
Toma S. 
                        ,
                            
Wang X. 
                        ,
                            
Suzuki T. 
                        ,
                            
Gu J. 
                        ,
                            
Miyoshi E. 
                        ,
                            
Tsukihara T. 
                        ,
                            
Honke K. 
                        ,
                            
Matsumoto A. 
                        ,
                            
Nakagawa A. 
                        ,
                            
Taniguchi N. 
                        
                        
                        
                        
                            Glycobiology17:455-466(2007)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for X-RAY CRYSTALLOGRAPHY (2.61 ANGSTROMS) OF 68-575;FUNCTION;CATALYTIC ACTIVITY;DISULFIDE BOND;MUTAGENESIS OF ARG-365; ASP-368; LYS-369; GLU-373; TYR-382; ASP-409; ASP-410; ASP-453 AND SER-469