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Index > Protein center > FZD1(Gene name) > Human
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  • FZD1 (Gene name),
  • Frizzled-1 (Protein name ),  FZD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FZD1;
    Protein name:
    Frizzled-1(Fz-1;hFz1);
    Alternative:
    FzE1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
    Subcellular Location:
    Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    647
    Sequence:
    50:
    MAEEEAPKKS | RAAGGGASWE | LCAGALSARL | AEEGSGDAGG | RRRPPVDPRR | 
    100:
    LARQLLLLLW | LLEAPLLLGV | RAQAAGQGPG | QGPGPGQQPP | PPPQQQQSGQ | 
    150:
    QYNGERGISV | PDHGYCQPIS | IPLCTDIAYN | QTIMPNLLGH | TNQEDAGLEV | 
    200:
    HQFYPLVKVQ | CSAELKFFLC | SMYAPVCTVL | EQALPPCRSL | CERARQGCEA | 
    250:
    LMNKFGFQWP | DTLKCEKFPV | HGAGELCVGQ | NTSDKGTPTP | SLLPEFWTSN | 
    300:
    PQHGGGGHRG | GFPGGAGASE | RGKFSCPRAL | KVPSYLNYHF | LGEKDCGAPC | 
    350:
    EPTKVYGLMY | FGPEELRFSR | TWIGIWSVLC | CASTLFTVLT | YLVDMRRFSY | 
    400:
    PERPIIFLSG | CYTAVAVAYI | AGFLLEDRVV | CNDKFAEDGA | RTVAQGTKKE | 
    450:
    GCTILFMMLY | FFSMASSIWW | VILSLTWFLA | AGMKWGHEAI | EANSQYFHLA | 
    500:
    AWAVPAIKTI | TILALGQVDG | DVLSGVCFVG | LNNVDALRGF | VLAPLFVYLF | 
    550:
    IGTSFLLAGF | VSLFRIRTIM | KHDGTKTEKL | EKLMVRIGVF | SVLYTVPATI | 
    600:
    VIACYFYEQA | FRDQWERSWV | AQSCKSYAIP | CPHLQAGGGA | PPHPPMSPDF | 
    647:
    TVFMIKYLMT | LIVGITSGFW | IWSGKTLNSW | RKFYTRLTNS | KQGETTV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Fz-1
    MSDS:
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    ELISA Kit for Human Fz-1
    Cat.:
    E11110m
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    Packing:
    96T
    ELISA Kit for Human Fz-1
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    E11110r
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    96T
    ELISA Kit for Human Fz-1
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    Packing:
    96T
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    CLIA Kit for Human Fz-1
    Cat.:
    U11110h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Fz-1
    Cat.:
    U11110r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fz-1
    Cat.:
    U11110m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fz-1
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Fz-1
    Polyclonal Antibody for Human Fz-1
    Polyclonal Antibody for Human Fz-1
    Polyclonal Antibody for Human Fz-1
    Cat.:
    P11110Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Fz-1
    Monoclonal Antibody for Human Fz-1
    Monoclonal Antibody for Human Fz-1
    Monoclonal Antibody for Human Fz-1
    Protein for Human Fz-1
    Protein for Human Fz-1
    Protein for Human Fz-1
    Protein for Human Fz-1

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    References
    1. 1.
      "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."
      Gazit A. , Yaniv A. , Bafico A. , Pramila T. , Igarashi M. , Kitajewski J. , Aaronson S.A.
      Oncogene18:5959-5966(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Prostatic carcinoma.
    2. 2.
      "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7."
      Sagara N. , Toda G. , Hirai M. , Terada M. , Katoh M.
      Biochem. Biophys. Res. Commun.252:117-122(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal lung.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    6. 7.
      "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
      Tanaka S. , Akiyoshi T. , Mori M. , Wands J.R. , Sugimachi K.
      Proc. Natl. Acad. Sci. U.S.A.95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 357-418
      tissue: Esophageal carcinoma.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYOC
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