FZD4 ELISA Kit for Human(Homo sapiens) | EIAab.comFZD4 ELISA Kit for Human(Homo sapiens)

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FZD4 (Gene name),

Frizzled-4 (Protein name ), FZD4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

FZD4;

Protein name:

Frizzled-4(Fz-4;hFz4);

Alternative:

FzE4;

CD:

CD344;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MAGI3 and norrin (NDP). Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP).

Function:

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

537

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

537:

LHTWQKCSNR | LVNSGKVKRE | KRGNGWVKPG | KGSETVV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8322

UniGene:

Hs.591968

SMR:

Q9ULV1

MIM:

133780

Pfam:

PF01534

String:

Q9ULV1

STRING:

9606.ENSP00000311581

Uniprot:

Q9ULV1

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ELISA Kit for Human Fz-4

Cat.:

E9388h

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96T

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ELISA Kit for Human Fz-4

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ELISA Kit for Human Fz-4

Cat.:

E9388m

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Packing:

96T

ELISA Kit for Human Fz-4

Cat.:

E9388r

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96T

CLIA Kit for Human Fz-4

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CLIA Kit for Human Fz-4

Cat.:

U9388r

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96T

CLIA Kit for Human Fz-4

Cat.:

U9388m

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MSDS:

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96T

CLIA Kit for Human Fz-4

Cat.:

U9388h

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96T

Polyclonal Antibody for Human Fz-4

Cat.:

P9388Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Fz-4

Cat.:

P9388Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Fz-4

Monoclonal Antibody for Human Fz-4

Protein for Human Fz-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of human frizzled-4 on chromosome 11q14-q21."
Kirikoshi H. , Sagara N. , Koike J. , Tanaka K. , Sekihara H. , Hirai M. , Katoh M.
Biochem. Biophys. Res. Commun.264:955-961(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal lung.
2.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Trachea.
4.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
Tanaka S. , Akiyoshi T. , Mori M. , Wands J.R. , Sugimachi K.
Proc. Natl. Acad. Sci. U.S.A.95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 257-318
tissue: Esophageal carcinoma.
7.

"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
Hao H.X. , Xie Y. , Zhang Y. , Charlat O. , Oster E. , Avello M. , Lei H. , Mickanin C. , Liu D. , Ruffner H. , Mao X. , Ma Q. , Zamponi R. , Bouwmeester T. , Finan P.M. , Kirschner M.W. , Porter J.A. , Serluca F.C. , more...
Nature485:195-200(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY ZNRF3
8.

"Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy."
Robitaille J. , MacDonald M.L.E. , Kaykas A. , Sheldahl L.C. , Zeisler J. , Dube M.-P. , Zhang L.-H. , Singaraja R.R. , Guernsey D.L. , Zheng B. , Siebert L.F. , Hoskin-Mott A. , Trese M.T. , Pimstone S.N. , Shastry B.S. , Moon R.T. , Hayden M.R. , Goldberg Y.P. , more...
Nat. Genet.32:326-330(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EVR1 493-MET-TRP-494 DEL;CHARACTERIZATION OF VARIANT EVR1 493-MET-TRP-494 DEL
9.

"Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity."
Kondo H. , Hayashi H. , Oshima K. , Tahira T. , Hayashi K.
Br. J. Ophthalmol.87:1291-1295(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 TYR-69; VAL-105; GLN-417 AND ASP-488
10.

"Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy."
Yoshida S. , Arita R. , Yoshida A. , Tada H. , Emori A. , Noda Y. , Nakao S. , Fujisawa K. , Ishibashi T.
Am. J. Ophthalmol.138:670-671(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EVR1 VAL-342
11.

"Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair."
Xu Q. , Wang Y. , Dabdoub A. , Smallwood P.M. , Williams J. , Woods C. , Kelley M.W. , Jiang L. , Tasman W. , Zhang K. , Nathans J.
Cell116:883-895(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 VAL-105 AND VAL-157;CHARACTERIZATION OF VARIANTS EVR1 VAL-105; VAL-157 AND 493-MET-TRP-494 DEL
12.

"Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy."
Toomes C. , Bottomley H.M. , Scott S. , Mackey D.A. , Craig J.E. , Appukuttan B. , Stout J.T. , Flaxel C.J. , Zhang K. , Black G.C.M. , Fryer A. , Downey L.M. , Inglehearn C.F.
Invest. Ophthalmol. Vis. Sci.45:2083-2090(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 ASP-36; THR-105; VAL-157 AND PHE-497;VARIANT SER-168
13.

"Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)."
Omoto S. , Hayashi T. , Kitahara K. , Takeuchi T. , Ueoka Y.
Ophthalmic Genet.25:81-90(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 TYR-69 AND ARG-181
14.

"Genetic variants of frizzled-4 gene in familial exudative vitreoretinopathy and advanced retinopathy of prematurity."
MacDonald M.L. , Goldberg Y.P. , Macfarlane J. , Samuels M.E. , Trese M.T. , Shastry B.S.
Clin. Genet.67:363-366(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 SER-33 AND VAL-256;VARIANT SER-168
15.

"Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes."
Qin M. , Hayashi H. , Oshima K. , Tahira T. , Hayashi K. , Kondo H.
Hum. Mutat.26:104-112(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 TYR-69; VAL-105; CYS-335; VAL-342; GLN-417 AND ASP-488
16.

"Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy."
Nallathambi J. , Shukla D. , Rajendran A. , Namperumalsamy P. , Muthulakshmi R. , Sundaresan P.
Mol. Vis.12:1086-1092(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 SER-33 AND ARG-204
17.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-436
18.

"Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy."
Qin M. , Kondo H. , Tahira T. , Hayashi K.
Hum. Genet.122:615-623(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS EVR1 VAL-105 AND GLN-417;CHARACTERIZATION OF VARIANT TYR-69
19.

"Clinical and molecular evaluation of probands and family members with familial exudative vitreoretinopathy."
Boonstra F.N. , van Nouhuys C.E. , Schuil J. , de Wijs I.J. , van der Donk K.P. , Nikopoulos K. , Mukhopadhyay A. , Scheffer H. , Tilanus M.A.D. , Cremers F.P.M. , Hoefsloot L.H.
Invest. Ophthalmol. Vis. Sci.50:4379-4385(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 SER-33; LYS-223 AND PRO-445;VARIANT SER-168
20.

"Phenotypic overlap of familial exudative vitreoretinopathy (FEVR) with persistent fetal vasculature (PFV) caused by FZD4 mutations in two distinct pedigrees."
Robitaille J.M. , Wallace K. , Zheng B. , Beis M.J. , Samuels M. , Hoskin-Mott A. , Guernsey D.L.
Ophthalmic Genet.30:23-30(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 THR-114 AND 493-MET-TRP-494 DEL
21.

"Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP."
Nikopoulos K. , Venselaar H. , Collin R.W.J. , Riveiro-Alvarez R. , Boonstra F.N. , Hooymans J.M. , Mukhopadhyay A. , Shears D. , van Bers M. , de Wijs I.J. , van Essen A.J. , Sijmons R.H. , Tilanus M.A.D. , van Nouhuys C.E. , Ayuso C. , Hoefsloot L.H. , Cremers F.P.M.
Hum. Mutat.31:656-666(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EVR1 GLN-40; TYR-204 AND ARG-525
22.

"Severe retinopathy of prematurity associated with FZD4 mutations."
Ells A. , Guernsey D.L. , Wallace K. , Zheng B. , Vincer M. , Allen A. , Ingram A. , DaSilva O. , Siebert L. , Sheidow T. , Beis J. , Robitaille J.M.
Ophthalmic Genet.31:37-43(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RETINOPATHY OF PREMATURITY ASN-203 AND GLY-370

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