Protein name:
Frizzled-8 (Fz-8;hFz8) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3.
Function:
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Subcellular Location:
Membrane
Multi-pass membrane protein
Golgi apparatus
Cell membrane
Multi-pass membrane protein
Colocalizes with GOPC at the Golgi apparatus.
Protein Attributes:
50:
MEWGYLLEVT | SLLAALALLQ | RSSGAAAASA | KELACQEITV | PLCKGIGYNY |
100:
TYMPNQFNHD | TQDEAGLEVH | QFWPLVEIQC | SPDLKFFLCS | MYTPICLEDY |
150:
KKPLPPCRSV | CERAKAGCAP | LMRQYGFAWP | DRMRCDRLPE | QGNPDTLCMD |
200:
YNRTDLTTAA | PSPPRRLPPP | PPGEQPPSGS | GHGRPPGARP | PHRGGGRGGG |
250:
GGDAAAPPAR | GGGGGGKARP | PGGGAAPCEP | GCQCRAPMVS | VSSERHPLYN |
300:
RVKTGQIANC | ALPCHNPFFS | QDERAFTVFW | IGLWSVLCFV | STFATVSTFL |
350:
IDMERFKYPE | RPIIFLSACY | LFVSVGYLVR | LVAGHEKVAC | SGGAPGAGGA |
400:
GGAGGAAAGA | GAAGAGAGGP | GGRGEYEELG | AVEQHVRYET | TGPALCTVVF |
450:
LLVYFFGMAS | SIWWVILSLT | WFLAAGMKWG | NEAIAGYSQY | FHLAAWLVPS |
500:
VKSIAVLALS | SVDGDPVAGI | CYVGNQSLDN | LRGFVLAPLV | IYLFIGTMFL |
550:
LAGFVSLFRI | RSVIKQQDGP | TKTHKLEKLM | IRLGLFTVLY | TVPAAVVVAC |
600:
LFYEQHNRPR | WEATHNCPCL | RDLQPDQARR | PDYAVFMLKY | FMCLVVGITS |
650:
GVWVWSGKTL | ESWRSLCTRC | CWASKGAAVG | GGAGATAAGG | GGGPGGGGGG |
694:
GPGGGGGPGG | GGGSLYSDVS | TGLTWRSGTA | SSVSYPKQMP | LSQV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Human
Rat
Polyclonal Antibody for Human Fz-8
Polyclonal Antibody for Human Fz-8
Polyclonal Antibody for Human Fz-8
Polyclonal Antibody for Human Fz-8
Monoclonal Antibody for Human Fz-8
Monoclonal Antibody for Human Fz-8
Monoclonal Antibody for Human Fz-8
Monoclonal Antibody for Human Fz-8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for NUCLEOTIDE SEQUENCE [MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for INTERACTION WITH LRP5 AND LRP6 IN THE WNT-FZD-LRP5-LRP6 COMPLEX;FUNCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for INTERACTION WITH GOPC
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for UBIQUITINATION BY ZNRF3
Vaild Sequence:
