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Index > Protein center > GAPDH(Gene name) > Dog
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  • GAPDH (Gene name),
  • Glyceraldehyde-3-phosphate dehydrogenase (Protein name ),  G3P_CANFA from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GAPDH(GAPD);
    Protein name:
    Glyceraldehyde-3-phosphate dehydrogenase(GAPDH);
    Alternative:
    2.6.99.-;Peptidyl-cysteine S-nitrosylase GAPDH);
    Organism:
    Dog (Canis familiarisCanis lupus familiaris). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
    Function:
    Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
    Protein Attributes:
    Sequence length:
    333
    Sequence:
    50:
    MVKVGVNGFG | RIGRLVTRAA | FNSGKVDIVA | INDPFIDLNY | MVYMFQYDST | 
    100:
    HGKFHGTVKA | ENGKLVINGK | SISIFQERDP | ANIKWGDAGA | EYVVESTGVF | 
    150:
    TTMEKAGAHL | KGGAKRVIIS | APSADAPMFV | MGVNHEKYDN | SLKIVSNASC | 
    200:
    TTNCLAPLAK | VIHDHFGIVE | GLMTTVHAIT | ATQKTVDGPS | GKMWRDGRGA | 
    250:
    AQNIIPASTG | AAKAVGKVIP | ELNGKLTGMA | FRVPTPNVSV | VDLTCRLEKA | 
    300:
    AKYDDIKKVV | KQASEGPLKG | ILGYTEDQVV | SCDFNSDTHS | STFDAGAGIA | 
    333:
    LNDHFVKLIS | WYDNEFGYSN | RVVDLMVYMA | SKE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
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    ELISA Kit for Dog GAPDH
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    E1932m
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    ELISA Kit for Dog GAPDH
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    E1932h
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    ELISA Kit for Dog GAPDH
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    E1932d
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    ELISA Kit for Dog GAPDH
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    E1932r
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    ELISA Kit for Dog GAPDH
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    ELISA Kit for Dog GAPDH
    Cat.:
    E1932p
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    ELISA Kit for Dog GAPDH
    Cat.:
    E1932b
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    ELISA Kit for Dog GAPDH
    Cat.:
    E1932c
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    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932b
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    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Dog GAPDH
    Cat.:
    U1932h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Dog GAPDH
    MSDS:
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    Polyclonal Antibody for Dog GAPDH
    Cat.:
    P1932Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Dog GAPDH
    Cat.:
    P1932Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Dog GAPDH
    Polyclonal Antibody for Dog GAPDH
    Polyclonal Antibody for Dog GAPDH
    Polyclonal Antibody for Dog GAPDH
    Polyclonal Antibody for Dog GAPDH
    Polyclonal Antibody for Dog GAPDH
    Cat.:
    P1932Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Monoclonal Antibody for Dog GAPDH
    Protein for Dog GAPDH
    Protein for Dog GAPDH
    Protein for Dog GAPDH
    Protein for Dog GAPDH
    Cat.:
    R1932h
    Price:
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Dog GAPDH
    Protein for Dog GAPDH
    Protein for Dog GAPDH
    Protein for Dog GAPDH

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    References
    1. 1.
      "Canine glyceraldehyde-3-phosphate dehydrogenase (GAPDH), complete CDS."
      Kitamura H. , Adachi K. , Kido N. , Hagiya T. , Minase K. , Yasui H. , Yano E. , Ohta Y. , Tabu K. , Mae J. , Kanehira K. , Ohashi A.
      Submitted (2000-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Adrenal gland.
    2. 2.
      "Canine glyceraldehyde-3-phosphate dehydrogenase complementary DNA: polymerase chain reaction amplification, cloning, partial sequence analysis, and use as loading control in ribonuclease protection assays."
      Groene A. , Weckmann M.T. , Capen C.C. , Rosol T.J.
      Am. J. Vet. Res.57:254-257(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-183
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