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Index > Protein center > Gapdh(Gene name) > Mouse
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  • Gapdh (Gene name),
  • Glyceraldehyde-3-phosphate dehydrogenase (Protein name ),  G3P_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Gapdh(Gapd);
    Protein name:
    Glyceraldehyde-3-phosphate dehydrogenase(GAPDH);
    Alternative:
    2.6.99.-;Peptidyl-cysteine S-nitrosylase GAPDH);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
    Function:
    Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
    Protein Attributes:
    Sequence length:
    333
    Sequence:
    50:
    MVKVGVNGFG | RIGRLVTRAA | ICSGKVEIVA | INDPFIDLNY | MVYMFQYDST | 
    100:
    HGKFNGTVKA | ENGKLVINGK | PITIFQERDP | TNIKWGEAGA | EYVVESTGVF | 
    150:
    TTMEKAGAHL | KGGAKRVIIS | APSADAPMFV | MGVNHEKYDN | SLKIVSNASC | 
    200:
    TTNCLAPLAK | VIHDNFGIVE | GLMTTVHAIT | ATQKTVDGPS | GKLWRDGRGA | 
    250:
    AQNIIPASTG | AAKAVGKVIP | ELNGKLTGMA | FRVPTPNVSV | VDLTCRLEKP | 
    300:
    AKYDDIKKVV | KQASEGPLKG | ILGYTEDQVV | SCDFNSNSHS | STFDAGAGIA | 
    333:
    LNDNFVKLIS | WYDNEYGYSN | RVVDLMAYMA | SKE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932h
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    Packing:
    96T
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    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932d
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    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932r
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    ELISA Kit for Mouse GAPDH
    MSDS:
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    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932p
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    96T
    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932b
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    MSDS:
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    96T
    ELISA Kit for Mouse GAPDH
    Cat.:
    E1932c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    Cat.:
    U1932h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse GAPDH
    MSDS:
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    Polyclonal Antibody for Mouse GAPDH
    Cat.:
    P1932Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse GAPDH
    Cat.:
    P1932Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse GAPDH
    Polyclonal Antibody for Mouse GAPDH
    Polyclonal Antibody for Mouse GAPDH
    Polyclonal Antibody for Mouse GAPDH
    Polyclonal Antibody for Mouse GAPDH
    Polyclonal Antibody for Mouse GAPDH
    Cat.:
    P1932Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Monoclonal Antibody for Mouse GAPDH
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH
    Cat.:
    R1932h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH
    Protein for Mouse GAPDH

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    References
    1. 1.
      "Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte."
      Sabath D.E. , Broome H.E. , Prystowsky M.B.
      Gene91:185-191(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: BALB/c.
      strain: C57BL/6J.
      strain: DBA/2.
      tissue: Cerebellum.
      tissue: Eye.
      tissue: Head.
      tissue: Kidney.
      tissue: Lung.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: 129.
      strain: C57BL/6.
      strain: C57BL/6J.
      strain: Czech II.
      strain: FVB/N.
      strain: FVB/N-3.
      tissue: Brain.
      tissue: Colon.
      tissue: Embryo.
      tissue: Eye.
      tissue: Mammary gland.
      tissue: Mammary tumor.
    5. 5.
      Lubec G. , Kang S.U. , Klug S. , Yang J.W. , Zigmond M. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-11; 27-50; 65-78; 85-105; 116-137; 144-189; 199-213; 218-246 AND 262-333;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      strain: OF1.
      tissue: Brain.
      tissue: Hippocampus.
    6. 6.
      "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M. , Nilsson M.A. , Arnason U. , Harley E.H. , Janke A.
      Mol. Biol. Evol.23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-249
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SULFHYDRATION AT CYS-150;MUTAGENESIS OF CYS-150
    8. 8.
      "Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages."
      Arif A. , Chatterjee P. , Moodt R.A. , Fox P.L.
      Mol. Cell. Biol.32:5046-5055(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;RECONSTITUTION OF THE GAIT COMPLEX
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