Protein name:
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) ;
Alternative:
2.6.99.-;Peptidyl-cysteine S-nitrosylase GAPDH ) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
Function:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
Protein Attributes:
50:
MVKVGVNGFG | RIGRLVTRAA | ICSGKVEIVA | INDPFIDLNY | MVYMFQYDST |
100:
HGKFNGTVKA | ENGKLVINGK | PITIFQERDP | TNIKWGEAGA | EYVVESTGVF |
150:
TTMEKAGAHL | KGGAKRVIIS | APSADAPMFV | MGVNHEKYDN | SLKIVSNASC |
200:
TTNCLAPLAK | VIHDNFGIVE | GLMTTVHAIT | ATQKTVDGPS | GKLWRDGRGA |
250:
AQNIIPASTG | AAKAVGKVIP | ELNGKLTGMA | FRVPTPNVSV | VDLTCRLEKP |
300:
AKYDDIKKVV | KQASEGPLKG | ILGYTEDQVV | SCDFNSNSHS | STFDAGAGIA |
333:
LNDNFVKLIS | WYDNEYGYSN | RVVDLMAYMA | SKE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Dog
Rat
Rabbit
Pig
Bovine
Chicken
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
ELISA Kit for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Polyclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
Monoclonal Antibody for Mouse GAPDH
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The transcriptional landscape of the mammalian genome."
Carninci P.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
BALB/c .
strain :
C57BL/6J .
strain :
DBA/2 .
tissue :
Cerebellum .
tissue :
Eye .
tissue :
Head .
tissue :
Kidney .
tissue :
Lung .
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
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more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 4-11; 27-50; 65-78; 85-105; 116-137; 144-189; 199-213; 218-246 AND 262-333;IDENTIFICATION BY MASS SPECTROMETRY
strain :
C57BL/6 .
strain :
OF1 .
tissue :
Brain .
tissue :
Hippocampus .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 24-249
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;SULFHYDRATION AT CYS-150;MUTAGENESIS OF CYS-150
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT;RECONSTITUTION OF THE GAIT COMPLEX