GPI ELISA Kit for Human(Homo sapiens) | EIAab.comGPI ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GPI(Gene name) > Human

GPI (Gene name),

Glucose-6-phosphate isomerase (Protein name ), G6PI_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GPI;

Protein name:

Glucose-6-phosphate isomerase(GPI);

Alternative:

Neuroleukin(NLK);Autocrine motility factor(AMF);Phosphohexose isomerase(PHI);Phosphoglucose isomerase(PGI);Sperm antigen 36(SA-36);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer in the catalytically active form, monomer in the secreted form.

Function:

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

Subcellular Location:

Cytoplasm Secreted

Protein Attributes:

Sequence length:

558

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

558:

QQREARVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P06744

UniGene:

Hs.466471

MIM:

172400

Pfam:

PF00342

STRING:

9606.ENSP00000348877

SMR:

P06744

KEGG:

hsa:2821

Uniprot:

P06744

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ELISA Kit for Human GPI

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E0725r

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96T

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ELISA Kit for Human GPI

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E0725h

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96T

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ELISA Kit for Human GPI

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ELISA Kit for Human GPI

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E0725p

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96T

ELISA Kit for Human GPI

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E0725m

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96T

ELISA Kit for Human GPI

Cat.:

E0725b

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96T

CLIA Kit for Human GPI

Cat.:

U0725p

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96T

CLIA Kit for Human GPI

Cat.:

U0725r

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96T

CLIA Kit for Human GPI

Cat.:

U0725h

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Packing:

96T

CLIA Kit for Human GPI

MSDS:

Please sign in first.

CLIA Kit for Human GPI

Cat.:

U0725m

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Packing:

96T

CLIA Kit for Human GPI

Cat.:

U0725b

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96T

Polyclonal Antibody for Human GPI

Cat.:

P0725Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human GPI

Cat.:

P0725Rb-h

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Polyclonal Antibody for Human GPI

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P0725Rb-r

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Monoclonal Antibody for Human GPI

Protein for Human GPI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

Gurney M.E.
Submitted (1987-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination."
Yakirevich E. , Naot Y.
Biol. Reprod.62:1016-1023(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Testis.
3.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-208
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Amygdala.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
7.

"Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI)."
Walker J.I.H. , Faik P. , Morgan M.J.
Genomics7:638-643(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-71
8.

Bienvenut W.V.
Submitted (2004-10) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12; 58-73; 97-104; 181-226; 424-438 AND 455-461;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: B-cell lymphoma.
9.

"Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences."
Faik P. , Walker J.I.H. , Redmill A.A.M. , Morgan M.J.
Nature332:455-456(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTITY OF NEUROLEUKIN AS PGI
10.

"Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein."
Haga A. , Niinaka Y. , Raz A.
Biochim. Biophys. Acta1480:235-244(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-185
11.

"Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility."
Funasaka T. , Haga A. , Raz A. , Nagase H.
Biochem. Biophys. Res. Commun.285:118-128(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
12.

"Species specificity of the cytokine function of phosphoglucose isomerase."
Amraei M. , Nabi I.R.
FEBS Lett.525:151-155(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPECIES SPECIFICITY OF THE CYTOKINE FUNCTION
13.

"Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
14.

"Differential regulation of phosphoglucose isomerase/autocrine motility factor activities by protein kinase CK2 phosphorylation."
Yanagawa T. , Funasaka T. , Tsutsumi S. , Raz T. , Tanaka N. , Raz A.
J. Biol. Chem.280:10419-10426(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-185;MUTAGENESIS OF SER-185
15.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-12 AND LYS-142;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"The first identification of lysine malonylation substrates and its regulatory enzyme."
Peng C. , Lu Z. , Xie Z. , Cheng Z. , Chen Y. , Tan M. , Luo H. , Zhang Y. , He W. , Yang K. , Zwaans B.M. , Tishkoff D. , Ho L. , Lombard D. , He T.C. , Dai J. , Verdin E. , Ye Y. , more...
Mol. Cell. Proteomics10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MALONYLATION AT LYS-454
21.

"The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia."
Read J. , Pearce J. , Li X. , Muirhead H. , Chirgwin J. , Davies C.
J. Mol. Biol.309:447-463(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS);SUBUNIT;ACTIVE SITE
22.

"Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies."
Tanaka N. , Haga A. , Uemura H. , Akiyama H. , Funasaka T. , Nagase H. , Raz A. , Nakamura K.T.
J. Mol. Biol.318:985-997(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) ALONE AND IN COMPLEX WITH INHIBITOR
23.

"The structure of human phosphoglucose isomerase complexed with a transition-state analogue."
Davies C. , Muirhead H. , Chirgwin J.
Acta Crystallogr. D59:1111-1113(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) IN COMPLEX WITH INHIBITOR;ACTIVE SITE
24.

"Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps."
Cordeiro A.T. , Godoi P.H. , Silva C.H. , Garratt R.C. , Oliva G. , Thiemann O.H.
Biochim. Biophys. Acta1645:117-122(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);ACTIVE SITE
25.

"DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency."
Walker J.I.H. , Layton D.M. , Bellingham A.J. , Morgan M.J. , Faik P.
Hum. Mol. Genet.2:327-329(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID SER-159; HIS-347 AND THR-525
26.

"The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia."
Xu W. , Beutler E.
J. Clin. Invest.94:2326-2329(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID TRP-83; MET-224; HIS-273; LEU-278; CYS-347; PHE-487 AND LYS-495
27.

"Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia."
Baronciani L. , Zanella A. , Bianchi P. , Zappa M. , Alfinito F. , Iolascon A. , Tannoia N. , Beutler E. , Sirchia G.
Blood88:2306-2310(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID MET-101; ILE-195; ARG-343 AND THR-525
28.

"Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia."
Kanno H. , Fujii H. , Hirono A. , Ishida Y. , Ohga S. , Fukumoto Y. , Matsuzawa K. , Ogawa S. , Miwa S.
Blood88:2321-2325(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID ILE-5; MET-224; ARG-343; ARG-375 AND ASN-539
29.

"Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA)."
Beutler E. , West C. , Britton H.A. , Harris J. , Forman L.
Blood Cells Mol. Dis.23:402-409(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID GLY-75; PRO-300; CYS-347 AND HIS-472
30.

"Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency."
Kugler W. , Breme K. , Laspe P. , Muirhead H. , Davies C. , Winkler H. , Schroter W. , Lakomek M.
Hum. Genet.103:450-454(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HA-GPID PRO-20; PRO-339; ARG-389 AND VAL-517

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